We would like to share ideas on “COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis.” [1] In contrast to liver transplant recipients, patients with chronic liver disease exhibited a good humoral response to the coronavirus disease 2019 (COVID-19) vaccination, according to Cheung et al. [1]. We also agree that COVID-19 is helpful in immunogenicity. The immunological response of a vaccine recipient with an underlying medical condition may be different from that of a healthy individual. Potential confounding factors must be taken into consideration while interpreting the current report. Prior asymptomatic COVID-19 infection is a possibility, and is not unusual [2]. If there is no method to rule out prior cases of asymptomatic COVID-19, it would be challenging to evaluate the effectiveness of the vaccine.