Pathology of nonalcoholic steatohepatitis

doi:2009.15.2.122

Korean J Hepatol > Volume 15(2); 2009 > Article

The Korean Journal of Hepatology 2009;15(2): 122-130.
doi: https://doi.org/10.3350/kjhep.2009.15.2.122

Pathology of nonalcoholic steatohepatitis

Yoon Mi Jeen , So Young Jin

Department of Pathology, Soonchunhyang University Hospital, Seoul, Korea

ABSTRACT

Nonalcoholic steatohepatitis (NASH), one of the NAFLDs (nonalcoholic fatty liver diseases), is regarded as a hepatic manifestation of metabolic syndrome. NASH can progress to cirrhosis, and possibly to hepatic malignancy. Currently, liver biopsy is the only reliable method of assessing the presence or absence of NASH and the stage of fibrosis. The finding of steatosis with evidence of hepatocyte injury such as inflammation, ballooning, degeneration, and/or fibrosis, is generally essential for making a diagnosis of NASH. However, its diagnostic criteria have not yet been established. The pathologic findings of NASH and related diseases, and the grading system currently in use are reviewed herein. (Korean J Hepatol 2009;15:122-130)

KeyWords: Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Needle biopsy; Activity score; Grading system