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"Georg Semmler"

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"Georg Semmler"

Reply to Correspondence

Liver fibrosis, cirrhosis, and portal hypertension

Citations

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  • Systemic inflammatory indexes as predictors of 18-month mortality among cirrhotic patients receiving transjugular intrahepatic portosystemic shunt
    Jie Cheng, Xiaobing Wang, Lihua Zhou, Xiaojia Chen, Nuer Tang, Feng Zhou, Feng Ding, Yuan Yang, Jun Lin, Liping Chen
    Annals of Medicine.2025;[Epub]     CrossRef
  • 6,063 View
  • 43 Download
  • 1 Web of Science
  • Crossref

Editorial

Liver fibrosis, cirrhosis, and portal hypertension

Citations

Citations to this article as recorded by  Crossref logo
  • TIPS insertion and systemic inflammation: Is it ever too late to lower portal pressure? Correspondence to editorial on “Insertion of a transjugular intrahepatic portosystemic shunt leads to sustained reversal of systemic inflammation in patients with deco
    Anja Tiede, Benjamin Maasoumy
    Clinical and Molecular Hepatology.2025; 31(2): e176.     CrossRef
  • Decreasing systemic inflammation after TIPS: Still hope for the liver: Reply to correspondence on “Insertion of a transjugular intrahepatic portosystemic shunt leads to sustained reversal of systemic inflammation in patients with decompensated liver cirrh
    Georg Semmler, Lorenz Balcar, Mattias Mandorfer
    Clinical and Molecular Hepatology.2025; 31(2): e224.     CrossRef
  • Refining Prognosis in Cirrhosis Patients With Ascites: Impact of Acute vs. Non‐Acute Decompensation
    Lucie Simonis, Lorenz Balcar, Anna Schedlbauer, Marta Tonon, Nikolaj Torp, Valeria Santori, Katharina Stopfer, Jan Embacher, Christian Sebesta, Leonie Hafner, Benedikt Silvester Hofer, Nina Dominik, Georg Kramer, Paul Thöne, Michael Trauner, Aleksander Kr
    Alimentary Pharmacology & Therapeutics.2025; 62(11-12): 1202.     CrossRef
  • Systemic inflammatory indexes as predictors of 18-month mortality among cirrhotic patients receiving transjugular intrahepatic portosystemic shunt
    Jie Cheng, Xiaobing Wang, Lihua Zhou, Xiaojia Chen, Nuer Tang, Feng Zhou, Feng Ding, Yuan Yang, Jun Lin, Liping Chen
    Annals of Medicine.2025;[Epub]     CrossRef
  • 6,770 View
  • 62 Download
  • 5 Web of Science
  • Crossref

Review

Steatotic liver disease

Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease
Georg Semmler, Christian Datz, Michael Trauner
Clin Mol Hepatol 2023;29(Suppl):S244-S260.
Published online December 14, 2022
DOI: https://doi.org/10.3350/cmh.2022.0364
Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding of how our diet influences our metabolism and focusing on specific effects on the liver, we provide a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD. Specifically, we emphasize the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet low in added fructose and processed meat that seems to exert favorable effects beyond calorie restriction. Also, we discuss intermittent fasting as a type of diet specifically tailored to decrease liver fat content and increase ketogenesis, awaiting future study results in NAFLD. Finally, personalized dietary recommendations could be powerful tools to increase the effectiveness of dietary interventions in patients with NAFLD considering the genetic background and the microbiome, among others.

Citations

Citations to this article as recorded by  Crossref logo
  • Association between dietary amino acid intake and the risk of metabolic dysfunction-associated steatotic liver disease
    Ruoqi Zhou, Xinrong Zhang, Xinxin Liu, Rui Huang, Yuwei Wang, Dajing Xia, Xue Li, Yihua Wu, Yu Shi
    Journal of Advanced Research.2026; 80: 893.     CrossRef
  • Ultrafiltered mulberry leaf glutelin mitigates non-alcoholic fatty liver disease through modulation of lipid metabolism, inflammation, and serum metabolomics
    Mingxi Li, Hongyan Li, Jia Zou, Renqin Li, Haoqi Zhang, Wenhan Yang, Xiyang Wu, Chongzhen Sun
    Food & Function.2026; 17(2): 819.     CrossRef
  • Long-Term Fructose Intake Induces Moderate Liver Inflammation but Does not Overlap with the Detrimental Effects of the Ketogenic Diet on Hepatic Steatosis in Rats
    Júlia Galbiati de Souza, Glaucivan Gomes Gurgel, Fernanda Marques Rodrigues, Ribanna Aparecida Marques Braga, Rosana Aparecida Manólio Soares, Luís Alberto de Pádua Covas Lage, Iberê Cauduro Soares, Débora Levy, Nágila Raquel Teixeira Damasceno
    Inflammation.2026;[Epub]     CrossRef
  • Effects of Intermittent Calorie Restriction in Nondiabetic Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease
    Han Ah Lee, Hyeyoung Moon, Yuri Kim, Jeong Kyong Lee, Hye Ah Lee, Hwi Young Kim
    Clinical Gastroenterology and Hepatology.2025; 23(1): 114.     CrossRef
  • Total choline intake, liver fibrosis and the progression of metabolic dysfunction-associated steatotic liver disease: Results from 2017 to 2020 NHANES
    Siraphat Taesuwan, Matina Kouvari, Andrew J. McKune, Demosthenes B. Panagiotakos, Julaluk Khemacheewakul, Noppol Leksawasdi, Pornchai Rachtanapun, Nenad Naumovski
    Maturitas.2025; 191: 108150.     CrossRef
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    Lara Russo, Serena Babboni, Maria Grazia Andreassi, Jalil Daher, Paola Canale, Serena Del Turco, Giuseppina Basta
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  • Monascus pilosus SWM-008 red mold rice and its components, monascinol and monascin, reduce obesity in a high-fat diet-induced rat model through synergistic modulation of gut microbiota and anti-lipogenesis
    Chin-Feng Liu, Hui-Tzu Chuang, Chia-Shu Wang, Ya-Wen Hsu, Tzu-Ming Pan, Chun-Lin Lee
    Food & Function.2025; 16(3): 966.     CrossRef
  • Dietary and lifestyle indices for hyperinsulinemia and odds of MAFLD in overweight and obese children and adolescents
    Ali Nikparast, Maryam Razavi, Parmis Mirzaei, Pooneh Dehghan, Mahdi Amani Farani, Golaleh Asghari
    Scientific Reports.2025;[Epub]     CrossRef
  • YouTube as a Source of Information for Dietary Guidance and Advisory Content in the Management of Non-Alcoholic Fatty Liver Disease
    Kagan Tur
    Healthcare.2025; 13(4): 351.     CrossRef
  • Sex-Specific Biochemical and Histopathological Effects of Chronic Meat-Based vs. Plant-Based Burger Consumption in a Rodent Model
    Cristina Filip, Ruxandra Ștefănescu, Bianca-Eugenia Ősz, Amalia Pușcaș, Corneliu Tanase, Adela Nechifor-Boilă, Amelia Tero-Vescan
    Foods.2025; 14(5): 888.     CrossRef
  • Non-alcoholic fatty liver disease: diet therapy and pharmacotherapy
    M. L. Maksimov, V. A. Dudareva, V. O. Vovk, V. I. Sklyarova, S. O. Ivashchenko, A. A. Shikaleva
    Terapevt (General Physician).2025; (3): 37.     CrossRef
  • Correspondence to editorial on “GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers”
    Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Jing Lin, Jin-Hong Chen
    Clinical and Molecular Hepatology.2025; 31(2): e186.     CrossRef
  • An umbrella review of the association between dietary factors and hepatocellular carcinoma risk
    Han Li, Qi-Hang Cao, Hui Liu, Lun-Jie Yan, Zi-Niu Ding, Han-Chao Wang, Rui Dong, Bao-Wen Tian, Cheng-Long Han, Zhao-Ru Dong, Long-Shan Yang, Xin-Cheng Mao, Yu-Chuan Yan, Dong-Xu Wang, Tao Li
    Food & Function.2025; 16(10): 3879.     CrossRef
  • ASS1 is a hub gene and possible therapeutic target for regulating metabolic dysfunction-associated steatotic liver disease modulated by a carbohydrate-restricted diet
    Shaojun Chen, Yanhua Bi, Lihua Zhang
    Molecular Diversity.2025; 29(4): 3717.     CrossRef
  • 2,5-Dihydroxybenzoic Acid Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Targeting the CCL2-CCR2 Axis to Reduce Lipid Accumulation
    Chien-Yun Hsiang, Kuang-Ting Hsu, Hsin-Yi Lo, Yun-Jhu Hou, Tin-Yun Ho
    Nutrients.2025; 17(11): 1835.     CrossRef
  • Food Nutrients and Bioactive Compounds for Managing Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review
    Erdenetsogt Dungubat, Kohei Fujikura, Masahiko Kuroda, Toshio Fukusato, Yoshihisa Takahashi
    Nutrients.2025; 17(13): 2211.     CrossRef
  • Amaranthus graecizans L. Mitigates Hyperlipidemia-Induced Nonalcoholic Fatty Liver Disease in Experimental Rats: Future Pharmaceuticals
    Nadiah S. Alzahrani, Bayan Aljahdali, Aeshah Alhosain, Abeer Abdullah Alasmari, Touseef Amna, Soha Mohamed Yousef
    Pharmaceuticals.2025; 18(8): 1196.     CrossRef
  • Higher Food Inflammation Index Is Linearly Associated With Higher Risk of MASLD: A Cross‐Sectional Study Based on the NHANES (1999–2020)
    Qingwan Yang, Xin Cai, Zhenghua Xiao
    Food Science & Nutrition.2025;[Epub]     CrossRef
  • Comparative efficacy of different diet modalities on metabolic profiles and liver functions in metabolic dysfunction-associated fatty liver disease: a network meta-analysis
    Jiahui Zou, Fei Tian, Shuqing Cui, Jing Hou, Zhenhua Li, Yaochen Wei, Haozhe Cui, Yunpeng Li, Shuanghao Zhou, Zechao He, Xiangming Ma
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • Ramadan fasting model exerts hepatoprotective, anti-obesity, and anti-hyperlipidemic effects in an experimentally-induced nonalcoholic fatty liver in rats
    Abeer A. Alasmari, Abdulrahman S. Al-Khalifah, Ahmed S. BaHammam, Noura M. S. Alshiban, Ahmad T. Almnaizel, Hesham S. Alodah, Maha H. Alhussain
    Saudi Journal of Gastroenterology.2024; 30(1): 53.     CrossRef
  • Decrease in Leptin Expression in the Liver after Prolonged Every-Other-Day Feeding in C57Bl/6 Male Mice
    Katarzyna Piotrowska, Maciej Tarnowski, Patrycja Tomasiak, Michał Czerewaty, Katarzyna Zgutka, Andrzej Pawlik
    Physiologia.2024; 4(1): 100.     CrossRef
  • Beneficial effects of intermittent fasting on nonalcoholic fatty liver disease: a narrative review
    Qingxuan Deng, Ruyue Lv, Haoqi Zou, Tangbin Zou
    Egyptian Liver Journal.2024;[Epub]     CrossRef
  • Metformin: Beyond Type 2 Diabetes Mellitus
    Rahnuma Ahmad, Mainul Haque
    Cureus.2024;[Epub]     CrossRef
  • Synergistic Effects of Fructose and Food Preservatives on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): From Gut Microbiome Alterations to Hepatic Gene Expression
    Tomas Hrncir, Eva Trckova, Lucia Hrncirova
    Nutrients.2024; 16(21): 3722.     CrossRef
  • The Interplay Between Depression, Probiotics, Diet, Immunometabolic Health, the Gut, and the Liver—A Secondary Analysis of the Pro-Demet Randomized Clinical Trial
    Oliwia Gawlik-Kotelnicka, Jakub Rogalski, Karolina H. Czarnecka-Chrebelska, Jacek Burzyński, Paulina Jakubowska, Anna Skowrońska, Dominik Strzelecki
    Nutrients.2024; 16(23): 4024.     CrossRef
  • Prevalence of Liver Steatosis Among Workers in Ouagadougou and Associated Factors: A Cross‐Sectional Study
    Delphine Napon‐Zongo, Jeoffray Diendere, Armel M. Sanou, Abou Coulibaly, Abdoulaye Dera, Nina G. M. Ouattara, Augustin N. Zeba, Seni Kouanda
    JGH Open.2024;[Epub]     CrossRef
  • Dietary modulation of gut microbiota affects susceptibility to drug-induced liver injury
    Han Pan, Delei Song, Zhiyi Wang, Xin Yang, Pei Luo, Wei Li, Yan Li, Mengxue Gong, Chenhong Zhang
    Gut Microbes.2024;[Epub]     CrossRef
  • Non-alcoholic fatty liver disease in people with normal body weight
    S. V. Turkina, I. A. Tyshchenko, M. N. Titarenko
    Experimental and Clinical Gastroenterology.2024; (10): 36.     CrossRef
  • Optimal choice of diet and food for NAFLD
    G. V. Shavkuta, L. B. Lazebnik
    Experimental and Clinical Gastroenterology.2024; (10): 98.     CrossRef
  • Effect of Nut Consumption on Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
    Ling Pan, Jing Sui, Ying Xu, Qun Zhao
    Nutrients.2023; 15(10): 2394.     CrossRef
  • Synergistic Effect of Diet and Physical Activity on a NAFLD Cohort: Metabolomics Profile and Clinical Variable Evaluation
    Francesco Maria Calabrese, Giuseppe Celano, Caterina Bonfiglio, Angelo Campanella, Isabella Franco, Alessandro Annunziato, Gianluigi Giannelli, Alberto Ruben Osella, Maria De Angelis
    Nutrients.2023; 15(11): 2457.     CrossRef
  • Diet and non-alcoholic fatty liver disease, a short narrative review
    W.J. Kwanten
    Acta Gastro Enterologica Belgica.2023; 86(2): 306.     CrossRef
  • β-hydroxybutyrate: A crucial therapeutic target for diverse liver diseases
    Ke Li, Wen-hong Wang, Jia-bin Wu, Wei-hua Xiao
    Biomedicine & Pharmacotherapy.2023; 165: 115191.     CrossRef
  • Correspondence on Letter regarding “Risk factors in nonalcoholic fatty liver disease”
    Eileen L. Yoon, Dae Won Jun
    Clinical and Molecular Hepatology.2023; 29(4): 1050.     CrossRef
  • 18,121 View
  • 417 Download
  • 31 Web of Science
  • Crossref
Editorial

Liver fibrosis, cirrhosis, and portal hypertension

Non-invasive tests-based risk stratification: Baveno VII and beyond
Georg Semmler, Mathias Jachs, Mattias Mandorfer
Clin Mol Hepatol 2023;29(1):105-109.
Published online November 23, 2022
DOI: https://doi.org/10.3350/cmh.2022.0361

Citations

Citations to this article as recorded by  Crossref logo
  • Early portal hypertension in metabolic dysfunction-associated steatotic liver disease: a concise review
    Iván López-Méndez, Eva Juárez-Hernández, Juan Pablo Soriano-Márquez, Misael Uribe, Graciela Castro-Narro
    Expert Review of Gastroenterology & Hepatology.2025; 19(7): 755.     CrossRef
  • Combination of modified albumin-bilirubin grade and platelet count to predict high-risk varices in patients with hepatocellular carcinoma
    Prooksa Ananchuensook, Kingkomon Piyawannasuth, Sirinporn Suksawatamnuay, Panarat Thaimai, Nipaporn Siripon, Supachaya Sriphoosanaphan, Kessarin Thanapirom, Piyawat Komolmit, Wenyu Lin
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  • Noninvasive model based on liver and spleen stiffness for predicting clinical decompensation in patients with cirrhosis
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    World Journal of Gastroenterology.2025;[Epub]     CrossRef
  • Simple blood tests to diagnose compensated advanced chronic liver disease and stratify the risk of clinically significant portal hypertension
    Georg Semmler, Lukas Hartl, Yuly Paulin Mendoza, Benedikt Simbrunner, Mathias Jachs, Lorenz Balcar, Michael Schwarz, Benedikt Silvester Hofer, Laurenz Fritz, Anna Schedlbauer, Katharina Stopfer, Daniela Neumayer, Jurij Maurer, Robin Szymanski, Elias Lauri
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    Alimentary Pharmacology & Therapeutics.2024; 60(2): 257.     CrossRef
  • Folic acid supplementation is associated with a decreased mortality and reduced hospital readmission in patients with decompensated alcohol-related liver cirrhosis
    Laura Buttler, Anja Tiede, Marie Griemsmann, Hannah Rieland, Jim Mauz, Julia Kahlhöfer, Heiner Wedemeyer, Markus Cornberg, Tammo L. Tergast, Benjamin Maasoumy, Katharina L. Hupa-Breier
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    Jeong-Ju Yoo, Sang Gyune Kim
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    Ruixue Ma, Yasuko Iwakiri
    Hepatology International.2023; 17(6): 1327.     CrossRef
  • 10,716 View
  • 151 Download
  • 11 Web of Science
  • Crossref