Clinical and Molecular Hepatology

"Haeryoung Kim"

Correspondences

Hepatic neoplasm

Correspondence to editorial on “Classification of microvascular invasion of hepatocellular carcinoma: correlation with prognosis and magnetic resonance imaging”: Haeryoung Kim, Dong Ho Lee, Yoon Jung Hwang; Clin Mol Hepatol 2024;30(4):992-993.
Published online August 5, 2024; DOI: https://doi.org/10.3350/cmh.2024.0624

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Reply to correspondence on “Severity of microvascular invasion does matter in hepatocellular carcinoma prognosis”
Abdelrahman M Attia, Hasmik Adetyan, Ju Dong Yang
Clinical and Molecular Hepatology.2024; 30(4): 1042. CrossRef

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47 Download
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Autoimmune liver disease

Reply to: “Evaluation of the histological scoring systems of autoimmune hepatitis: A significant step towards the optimization of clinical diagnosis”: Haeryoung Kim, Sook-Hyang Jeong; Clin Mol Hepatol 2024;30(2):291-292.
Published online March 19, 2024; DOI: https://doi.org/10.3350/cmh.2024.0180

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Reply to correspondence on “Comparison of four histological scoring systems for autoimmune hepatitis to improve diagnostic sensitivity”
Atsumasa Komori
Clinical and Molecular Hepatology.2024; 30(4): 1035. CrossRef

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Original Articles

Autoimmune liver disease

Comparison of four histological scoring systems for autoimmune hepatitis to improve diagnostic sensitivity: Soomin Ahn, Sook-Hyang Jeong, Eun Ju Cho, Kyoungbun Lee, Gilhyang Kim, Haeryoung Kim; Clin Mol Hepatol 2024;30(1):37-48.
Published online November 13, 2023; DOI: https://doi.org/10.3350/cmh.2023.0325

Abstract
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Background/Aims
The histological criteria in the 1999 and 2008 scoring systems proposed by the International Autoimmune Hepatitis Group (IAIHG) have their inherent limitations in diagnosing autoimmune hepatitis (AIH). In this study, we evaluated the histology components of four scoring systems (1. revised original scoring system [“1999 IAIHG”], 2. simplified scoring system [“2008 IAIHG”], 3. modified histologic criteria [“2017 UCSF”], and 4. a new histologic criteria proposed by the International AIH Pathology Group [“2022 IAHPG”]) in AIH patients.
Methods
Medical records and liver biopsies were retrospectively reviewed for 68 patients from two independent medical institutions, diagnosed with AIH based on the 1999 IAIHG system between 2006 and 2016. The histological features were reviewed in detail, and the four histological scoring systems were compared.
Result
s: Out of the 68 patients, 56 (82.4%) patients met the “probable” or “definite” AIH criteria of the 2008 IAIHG system, and the proportion of histologic score 2 (maximum) was 40/68 (58.8%). By applying the 2017 UCSF criteria, the number of histology score 2 increased to 60/68 (88.2%), and “probable” or “definite” AIH cases increased to 61/68 (89.7%). Finally, applying the 2022 IAHPG histology score resulted in the highest number of cases with histologic score 2 (64/68; 94.1%) and with a diagnosis of “probable” or “definite” AIH (62/68; 91.2%).
Conclusions
The recently proposed UCSF/IAHPG histological criteria increased the histology score of AIH. Substituting the histology component of the 2008 IAIHG system with the 2022 IAHPG criteria increased the sensitivity for diagnosing AIH (≥“Probable AIH”) from 82.4% to 91.2%.

Citations

Citations to this article as recorded by

Quo vadis autoimmune hepatitis? - Summary of the 5th international autoimmune hepatitis group research workshop 2024
Bastian Engel, David N. Assis, Mamatha Bhat, Jan Clusmann, Joost PH. Drenth, Alessio Gerussi, María-Carlota Londoño, Ye Htun Oo, Ida Schregel, Marcial Sebode, Richard Taubert
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Despoina Myoteri, Stratigoula Sakellariou, Dina G. Tiniakos
Advances in Anatomic Pathology.2025; 32(6): 414. CrossRef
EASL Clinical Practice Guidelines on the management of autoimmune hepatitis
George Dalekos, Nikolaos Gatselis, Joost P. Drenth, Michael Heneghan, Marianne Jørgensen, Ansgar W. Lohse, Maria Londoño, Luigi Muratori, Maria Papp, Marianne Samyn, Dina Tiniakos, Ana Lleo
Journal of Hepatology.2025; 83(2): 453. CrossRef
Evaluation of the histological scoring systems of autoimmune hepatitis: A significant step towards the optimization of clinical diagnosis
Atsumasa Komori
Clinical and Molecular Hepatology.2024; 30(2): 157. CrossRef
Reply to: “Evaluation of the histological scoring systems of autoimmune hepatitis: A significant step towards the optimization of clinical diagnosis”
Haeryoung Kim, Sook-Hyang Jeong
Clinical and Molecular Hepatology.2024; 30(2): 291. CrossRef
Reply to correspondence on “Comparison of four histological scoring systems for autoimmune hepatitis to improve diagnostic sensitivity”
Atsumasa Komori
Clinical and Molecular Hepatology.2024; 30(4): 1035. CrossRef
The utility of the mHAI scoring system in pediatric autoimmune hepatitis diagnosis and its association with treatment response
Wei Chen, Gillian Noel, Mansi Amin, Fengming Chen
Annals of Diagnostic Pathology.2024; 73: 152381. CrossRef
Diagnosis and Treatment of Patients with Autoimmune Hepatitis (Experts’ Agreement)
Yu. G. Sandler, E. V. Vinnitskaya, K. L. Raikhelson, K. V. Ivashkin, S. N. Batskikh, E. N. Aleksandrova, D. T. Abdurakhmanov, D. I. Abdulganieva, I. G. Bakulin, A. O. Bueverov, S. L. Vorobyev, O. A. Gerasimova, A. I. Dolgushina, M. S. Zhuravleva, L. Yu. I
Russian Journal of Gastroenterology, Hepatology, Coloproctology.2024; 34(6): 100. CrossRef

7,949 View
264 Download
6 Web of Science
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Hepatic neoplasm

Classification of microvascular invasion of hepatocellular carcinoma: correlation with prognosis and magnetic resonance imaging: Yoon Jung Hwang, Jae Seok Bae, Youngeun Lee, Bo Yun Hur, Dong Ho Lee, Haeryoung Kim; Clin Mol Hepatol 2023;29(3):733-746.
Published online May 8, 2023; DOI: https://doi.org/10.3350/cmh.2023.0034

Background/Aims
The microvascular invasion (MVI) of hepatocellular carcinoma (HCC) involves a wide histological spectrum, and it is unclear whether the degree of MVI correlates with patient prognosis or imaging findings. Here, we evaluate the prognostic value of MVI classification and analyze the radiologic features predictive of MVI.
Methods
Using a retrospective cohort of 506 patients with resected solitary HCCs, the histological and imaging features of MVI were reviewed and correlated with clinical data.
Result
s: MVI-positive HCCs invading ≥5 vessels or those with ≥50 invaded tumor cells were significantly associated with decreased overall survival (OS). The 5-year OS, recurrence-free survival (RFS), and beyond Milan criteria RFS rates were significantly poorer in patients with severe MVI compared with those with mild or no MVI. Severe MVI was a significant independent predictive factor for OS (odds ratio [OR], 2.962; p<0.001), RFS (OR, 1.638; p=0.002), and beyond Milan criteria RFS (OR, 2.797; p<0.001) on multivariable analysis. On MRI, non-smooth tumor margins (OR, 2.224; p=0.023) and satellite nodules (OR, 3.264; p<0.001) were independently associated with the severe-MVI group on multivariable analysis. Both non-smooth tumor margins and satellite nodules were associated with worse 5-year OS, RFS, and beyond Milan criteria RFS.
Conclusions
Histologic risk classification of MVI according to the number of invaded microvessels and invading carcinoma cells was a valuable predictor of prognosis in HCC patients. Non-smooth tumor margin and satellite nodules were significantly associated with severe MVI and poor prognosis.

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Snapshot

Autoimmune liver disease

Epidemiology and updated management for autoimmune liver disease: Nae-Yun Heo, Haeryoung Kim; Clin Mol Hepatol 2023;29(1):194-196.
Published online December 14, 2022; DOI: https://doi.org/10.3350/cmh.2022.0387

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Comparison of four histological scoring systems for autoimmune hepatitis to improve diagnostic sensitivity
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Review

Steatotic liver disease

Non-alcoholic fatty liver disease: the pathologist’s perspective: Wei-Qiang Leow, Anthony Wing-Hung Chan, Paulo Giovanni L. Mendoza, Regina Lo, Kihan Yap, Haeryoung Kim; Clin Mol Hepatol 2023;29(Suppl):S302-S318.
Published online November 15, 2022; DOI: https://doi.org/10.3350/cmh.2022.0329

Abstract
PDF

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases characterized by fatty accumulation in hepatocytes, ranging from steatosis, non-alcoholic steatohepatitis, to cirrhosis. While histopathological evaluation of liver biopsies plays a central role in the diagnosis of NAFLD, limitations such as the problem of interobserver variability still exist and active research is underway to improve the diagnostic utility of liver biopsies. In this article, we provide a comprehensive overview of the histopathological features of NAFLD, the current grading and staging systems, and discuss the present and future roles of liver biopsies in the diagnosis and prognostication of NAFLD.

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Guideline

Steatotic liver disease

KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease: Seong Hee Kang, Hye Won Lee, Jeong-Ju Yoo, Yuri Cho, Seung Up Kim, Tae Hee Lee, Byoung Kuk Jang, Sang Gyune Kim, Sang Bong Ahn, Haeryoung Kim, Dae Won Jun, Joon-Il Choi, Do Seon Song, Won Kim, Soung Won Jeong, Moon Young Kim, Hong Koh, Sujin Jeong, Jin-Woo Lee, Yong Kyun Cho, on behalf of The Korean Association for the Study of the Liver (KASL); Clin Mol Hepatol 2021;27(3):363-401.
Published online June 22, 2021; DOI: https://doi.org/10.3350/cmh.2021.0178

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Hepatology International.2024; 18(S2): 922. CrossRef
A New Korean Nomenclature for Steatotic Liver Disease

The Korean Journal of Gastroenterology.2024; 84(1): 1. CrossRef
Barriers to care linkage and educational impact on unnecessary MASLD referrals
Jun-Hyuk Lee, Eileen Laurel Yoon, Ju Hyun Oh, Kyunam Kim, Sang Bong Ahn, Dae Won Jun
Frontiers in Medicine.2024;[Epub] CrossRef
Immune system dysregulation in the pathogenesis of non-alcoholic steatohepatitis: unveiling the critical role of T and B lymphocytes
Merve Cebi, Yusuf Yilmaz
Frontiers in Immunology.2024;[Epub] CrossRef
A New Korean Nomenclature for Steatotic Liver Disease

The Korean Journal of Medicine.2024; 99(4): 189. CrossRef
Agile 3+ and Agile 4 scores predict chronic kidney disease development in metabolic dysfunction‐associated steatotic liver disease
Chan‐Young Jung, Jung Il Lee, Sang Hoon Ahn, Seung Up Kim, Beom Seok Kim
Alimentary Pharmacology & Therapeutics.2024; 60(8): 1051. CrossRef
A New Korean Nomenclature for Steatotic Liver Disease

Gut and Liver.2024; 18(5): 924. CrossRef
A new Korean nomenclature for steatotic liver disease

Clinical and Molecular Hepatology.2024; 30(Suppl): S214. CrossRef
Metabolic dysfunction‐associated steatotic liver disease and MetALD increases the risk of liver cancer and gastrointestinal cancer: A nationwide cohort study
Yewan Park, Jooyi Jung, Seungbong Han, Gi‐Ae Kim
Alimentary Pharmacology & Therapeutics.2024; 60(11-12): 1599. CrossRef
Comparative associations of MASLD and MAFLD with the presence and severity of coronary artery calcification
Min Kyu Kang, Jeong Eun Song, Rohit Loomba, Soo Young Park, Won Young Tak, Young Oh Kweon, Yu Rim Lee, Jung Gil Park
Scientific Reports.2024;[Epub] CrossRef
A narrative review of lifestyle management guidelines for metabolic dysfunction–associated steatotic liver disease
Dana Ivancovsky Wajcman, Christopher J. Byrne, John F. Dillon, Paul N. Brennan, Marcela Villota-Rivas, Zobair M. Younossi, Alina M. Allen, Javier Crespo, Lynn H. Gerber, Jeffrey V. Lazarus
Hepatology.2024;[Epub] CrossRef
Visceral Obesity and Its Association with Severe Coronary Artery Calcification in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease
Min Kyu Kang, Jeung Eun Song, Young Oh Kweon, Won Young Tak, Soo Young Park, Yu Rim Lee, Jung Gil Park
Diagnostics.2024; 14(20): 2305. CrossRef
Pathogenesis and management of metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma: a narrative review
Han Ah Lee
The Ewha Medical Journal.2024;[Epub] CrossRef
Evaluation of hepatoprotective and nephroprotective activities of Castanopsis costata extract in rats
Maulana Alkandahri, Asman Sadino, Ermi Abriyani, Faizal Hermanto, Zulpakor Oktoba, Muhammad Sayoeti, Putu Sangging, Diah Wardani, Nahrul Hasan, Suci Sari, Nurul Safitri, Windi Ikhtianingsih, Safitri Safitri
Biomedical Reports.2024;[Epub] CrossRef
Cross-talk between gut microbiota and liver steatosis: Complications and therapeutic target
Yuan Yao, Yunfeng Shen
Open Life Sciences.2023;[Epub] CrossRef
Association of Physical Activity With Risk of Liver Fibrosis, Sarcopenia, and Cardiovascular Disease in Nonalcoholic Fatty Liver Disease
Ho Soo Chun, Minjong Lee, Hye Ah Lee, Seo Yeong Oh, Hyo Jeong Baek, Jae Won Moon, Yeon Jeong Kim, Jinha Lee, Hyoeun Kim, Hwi Young Kim, Kwon Yoo, Tae Hun Kim, Seung Up Kim
Clinical Gastroenterology and Hepatology.2023; 21(2): 358. CrossRef
Non-Invasive Liver Fibrosis Scores Are Associated With Contrast-Associated Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention
Hao-Ming He, Chen He, Zhe-Bin You, Si-Cheng Zhang, Xue-Qin Lin, Man-Qing Luo, Mao-Qing Lin, Li-Wei Zhang, Kai-Yang Lin, Yan-Song Guo
Angiology.2023; 74(4): 333. CrossRef
Nonalcoholic Fatty Liver Disease Without Metabolic-associated Fatty Liver Disease and the Risk of Metabolic Syndrome
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Clinical Gastroenterology and Hepatology.2023; 21(7): 1873. CrossRef
The association of non‐alcoholic fatty liver disease between parents and adolescent children
Yewan Park, Dong Hyun Sinn, Kyunga Kim, Geum‐Youn Gwak
Alimentary Pharmacology & Therapeutics.2023; 57(2): 245. CrossRef
Statin use is associated with better post‐operative prognosis among patients with hepatitis B virus‐related hepatocellular carcinoma
Byungyoon Yun, Sang Hoon Ahn, Juyeon Oh, Jin‐Ha Yoon, Beom Kyung Kim
European Journal of Clinical Investigation.2023;[Epub] CrossRef
Reply
Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak
Clinical Gastroenterology and Hepatology.2023; 21(9): 2435. CrossRef
Positive association between nonalcoholic fatty liver disease and growth hormone deficiency in patients with nonfunctioning pituitary adenoma
Yoon-a Hwang, Hye Won Lee, Sang Hoon Ahn, Eun Jig Lee, Cheol Ryong Ku, Seung Up Kim
Frontiers in Endocrinology.2023;[Epub] CrossRef
Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
Sun Young Shim, Sun Jae Jung, Seung Up Kim, Hyeon Chang Kim
Clinical Hypertension.2023;[Epub] CrossRef
Correspondence on Editorial regarding “Impact of nationwide hepatocellular carcinoma surveillance on the prognosis in patients with chronic liver disease”
Won Sohn, Yong-Han Paik
Clinical and Molecular Hepatology.2023; 29(1): 182. CrossRef
Correspondence on Editorial regarding “Screening and prediction of nonalcoholic fatty liver disease using a peripheral insulin resistance index: Potential benefits and limitations”
Jun-Hyuk Lee, Kyongmin Park, Hye Sun Lee, Hoon-Ki Park, Jee Hye Han, Sang Bong Ahn
Clinical and Molecular Hepatology.2023; 29(1): 185. CrossRef
Correspondence on Letter regarding “Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF-κB signaling pathways”
Seung Min Lee, Dae Won Jun
Clinical and Molecular Hepatology.2023; 29(1): 171. CrossRef
Correspondence on Letter regarding “The usefulness of metabolic score for insulin resistance for the prediction of incident non-alcoholic fatty liver disease in Korean adults”
Jun-Hyuk Lee, Kyongmin Park, Hye Sun Lee, Hoon-Ki Park, Jee Hye Han, Sang Bong Ahn
Clinical and Molecular Hepatology.2023; 29(1): 179. CrossRef
Recurrence of hepatocellular carcinoma in noncirrhotic patients with nonalcoholic fatty liver disease versus hepatitis B infection
Jungnam Lee, Jong-In Chang, Young-Joo Jin, Jeong-Hoon Lee, Ju Yeon Kim, Dong Hyun Sinn, Soon Sun Kim, Hyun Woong Lee, Sun Hong Yoo, Jung Hwan Yu, Jin-Woo Lee
European Journal of Gastroenterology & Hepatology.2023; 35(4): 431. CrossRef
Comparison of Guidelines for the Screening, Diagnosis, and Noninvasive Assessment of Nonalcoholic Fatty Liver Disease
Kenneth W. Chow, Pragyat Futela, Aryan Saharan, Sammy Saab
Journal of Clinical and Experimental Hepatology.2023; 13(5): 783. CrossRef
Clinical Implications of Cardiac Symptoms and Electrocardiographic Abnormalities for Advanced Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
Min-Kyu Kang, Min-Cheol Kim
Medicina.2023; 59(2): 375. CrossRef
The independent effect of exercise on biopsy-proven non-alcoholic fatty liver disease: A systematic review
George Chen, Bubu Banini, Albert Do, Joseph K. Lim
Clinical and Molecular Hepatology.2023; 29(Suppl): S319. CrossRef
Preventive strategy for nonalcoholic fatty liver disease-related hepatocellular carcinoma
Yuri Cho, Bo Hyun Kim, Joong-Won Park
Clinical and Molecular Hepatology.2023; 29(Suppl): S220. CrossRef
Global incidence and prevalence of nonalcoholic fatty liver disease
Margaret LP Teng, Cheng Han Ng, Daniel Q. Huang, Kai En Chan, Darren JH Tan, Wen Hui Lim, Ju Dong Yang, Eunice Tan, Mark D. Muthiah
Clinical and Molecular Hepatology.2023; 29(Suppl): S32. CrossRef
Non-alcoholic fatty liver disease: the pathologist’s perspective
Wei-Qiang Leow, Anthony Wing-Hung Chan, Paulo Giovanni L. Mendoza, Regina Lo, Kihan Yap, Haeryoung Kim
Clinical and Molecular Hepatology.2023; 29(Suppl): S302. CrossRef
Preventive effect of empagliflozin and ezetimibe on hepatic steatosis in adults and murine models
Dong Yun Kim, Kyu Sik Chung, Jun Yong Park, Heon Yung Gee
Biomedicine & Pharmacotherapy.2023; 161: 114445. CrossRef
Effects of additive interactions among obesity, visceral adiposity, and sarcopenia on nonalcoholic fatty liver disease
Goh Eun Chung, Sohee Oh, Dong-Won Ahn, Su Hwan Kim, Yong Jin Jung, Ji Won Kim, Byeong Gwan Kim, Kook Lae Lee, Ji Bong Jeong
Scientific Reports.2023;[Epub] CrossRef
Screening strategy for non-alcoholic fatty liver disease
Saisai Zhang, Lung-Yi Mak, Man-Fung Yuen, Wai-Kay Seto
Clinical and Molecular Hepatology.2023; 29(Suppl): S103. CrossRef
Noninvasive serum biomarkers for liver fibrosis in NAFLD: current and future
Tina Reinson, Ryan M. Buchanan, Christopher D. Byrne
Clinical and Molecular Hepatology.2023; 29(Suppl): S157. CrossRef
Baseline Tyrosine Level Is Associated with Dynamic Changes in FAST Score in NAFLD Patients under Lifestyle Modification
Hwi Young Kim, Da Jung Kim, Hye Ah Lee, Joo-Youn Cho, Won Kim
Metabolites.2023; 13(3): 444. CrossRef
Nonalcoholic fatty liver disease and non-liver comorbidities
Richie Manikat, Mindie H. Nguyen
Clinical and Molecular Hepatology.2023; 29(Suppl): s86. CrossRef
Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease
Peter Konyn, Aijaz Ahmed, Donghee Kim
Clinical and Molecular Hepatology.2023; 29(Suppl): S43. CrossRef
Pharmacological advances in the treatment of nonalcoholic fatty liver diseases : focused on global results of randomized controlled trials
Jihyun An, Joo Hyun Sohn
Clinical and Molecular Hepatology.2023; 29(Suppl): S268. CrossRef
Noninvasive serum biomarkers for liver steatosis in nonalcoholic fatty liver disease: Current and future developments
Sang Bong Ahn
Clinical and Molecular Hepatology.2023; 29(Suppl): S150. CrossRef
Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future
Asako Nogami, Masato Yoneda, Michihiro Iwaki, Takashi Kobayashi, Yasushi Honda, Yuji Ogawa, Kento Imajo, Satoru Saito, Atsushi Nakajima
Clinical and Molecular Hepatology.2023; 29(Suppl): S123. CrossRef
Comparison between obese and non-obese nonalcoholic fatty liver disease
Wah-Kheong Chan
Clinical and Molecular Hepatology.2023; 29(Suppl): S58. CrossRef
Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future
Jung Hwan Yu, Han Ah Lee, Seung Up Kim
Clinical and Molecular Hepatology.2023; 29(Suppl): S136. CrossRef
Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease
Georg Semmler, Christian Datz, Michael Trauner
Clinical and Molecular Hepatology.2023; 29(Suppl): S244. CrossRef
Non-alcoholic fatty liver disease: Definition and subtypes
Seul Ki Han, Soon Koo Baik, Moon Young Kim
Clinical and Molecular Hepatology.2023; 29(Suppl): S5. CrossRef
The effects of moderate alcohol consumption on non-alcoholic fatty liver disease
Hyunwoo Oh, Won Sohn, Yong Kyun Cho
Clinical and Molecular Hepatology.2023; 29(Suppl): S261. CrossRef
Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis
Yi-wen Shi, Jian-Gao Fan
Clinical and Molecular Hepatology.2023; 29(Suppl): S228. CrossRef
Bariatric surgery for non-alcoholic fatty liver disease: Indications and post-operative management
Anja Geerts, Sander Lefere
Clinical and Molecular Hepatology.2023; 29(Suppl): S276. CrossRef
Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management
Sara Battistella, Francesca D’Arcangelo, Marco Grasso, Alberto Zanetto, Martina Gambato, Giacomo Germani, Marco Senzolo, Francesco Paolo Russo, Patrizia Burra
Clinical and Molecular Hepatology.2023; 29(Suppl): S286. CrossRef
CT-based Hounsfield unit values reflect the degree of steatohepatitis in patients with low-grade fatty liver disease
Ha Neul Kim, Hong Jae Jeon, Hei Gwon Choi, In Sun Kwon, Woo Sun Rou, Jeong Eun Lee, Tae Hee Lee, Seok Hyun Kim, Byung Seok Lee, Kyung Sook Shin, Hyun Jung Lee, Hyuk Soo Eun
BMC Gastroenterology.2023;[Epub] CrossRef
How many times should we repeat measurements of the ultrasound-guided attenuation parameter for evaluating hepatic steatosis?
Duck Min Seo, Sang Min Lee, Ji Won Park, Min-Jeong Kim, Hong Il Ha, Sun-Young Park, Kwanseop Lee
Ultrasonography.2023; 42(2): 227. CrossRef
The independent effect of exercise on biopsy proven non-alcoholic fatty liver disease: A systematic review
Young-Joo Jin
Clinical and Molecular Hepatology.2023; 29(2): 414. CrossRef
Hepatocellular carcinoma surveillance in non-alcoholic fatty liver disease – who and how?
Margaret LP Teng, Darren Jun Hao Tan, Cheng Han Ng, Daniel Q. Huang
Clinical and Molecular Hepatology.2023; 29(2): 404. CrossRef
The effect of moderate alcohol consumption on nonalcoholic fatty liver disease
Ji-Won Park, Ki Tae Suk
Clinical and Molecular Hepatology.2023; 29(2): 408. CrossRef
Screening strategies for non-alcoholic fatty liver disease: a holistic approach is needed
Philipp Kasper, Münevver Demir, Hans-Michael Steffen
Clinical and Molecular Hepatology.2023; 29(2): 390. CrossRef
Global burden of primary liver cancer and its association with underlying aetiologies, sociodemographic status, and sex differences from 1990–2019: A DALY-based analysis of the Global Burden of Disease 2019 study
Sungchul Choi, Beom Kyung Kim, Dong Keon Yon, Seung Won Lee, Han Gyeol Lee, Ho Hyeok Chang, Seoyeon Park, Ai Koyanagi, Louis Jacob, Elena Dragioti, Joaquim Radua, Jae Il Shin, Seung Up Kim, Lee Smith
Clinical and Molecular Hepatology.2023; 29(2): 433. CrossRef
The growing burden of non-alcoholic fatty liver disease on mortality
Ju-Yeon Cho, Won Sohn
Clinical and Molecular Hepatology.2023; 29(2): 374. CrossRef
Impact of metabolic factors on risk of cardiovascular disease in nondiabetic metabolic dysfunction-associated fatty liver disease
Min Kyu Kang, Yu Rim Lee, Se Young Jang, Won Young Tak, Young Oh Kweon, Jeong Eun Song, Rohit Loomba, Soo Young Park, Jung Gil Park
Hepatology International.2023; 17(3): 626. CrossRef
Genetic association study identifies genetic variants for non-alcoholic fatty liver without comorbidities in the Korean population
Yeon Jun Kim, Yoon Shin Cho
Genes & Genomics.2023; 45(7): 847. CrossRef
Association between the fatty liver index and the risk of fracture among individuals over the age of 50 years: a nationwide population-based study
Goh Eun Chung, Eun Ju Cho, Min Joo Kim, Jeong-Ju Yoo, Yuri Cho, Kyu-na Lee, Kyungdo Han, Yoon Jun Kim, Jung-Hwan Yoon, Dong Wook Shin, Su Jong Yu
Frontiers in Endocrinology.2023;[Epub] CrossRef
Therapeutic Mechanisms and Clinical Effects of Glucagon-like Peptide 1 Receptor Agonists in Nonalcoholic Fatty Liver Disease
Han Ah Lee, Hwi Young Kim
International Journal of Molecular Sciences.2023; 24(11): 9324. CrossRef
Low‐quality muscle mass rather than normal‐quality muscle mass determines fibrosis progression in biopsy‐proven NAFLD
Yun Kyu Lee, Bo Kyung Koo, Sae Kyung Joo, Dong Hyeon Lee, Heejoon Jang, Jee Won Chai, Myoung Seok Lee, Si Won Jang, Young Ho So, Jeong Hwan Park, Mee Soo Chang, Won Kim
Alimentary Pharmacology & Therapeutics.2023; 58(3): 322. CrossRef
Clinical and histologic factors associated with discordance between steatosis grade derived from histology vs. MRI‐PDFF in NAFLD
Beom K. Kim, Nicole Bernstein, Daniel Q. Huang, Nobuharu Tamaki, Kento Imajo, Masato Yoneda, Nancy Sutter, Jinho Jung, Khang Nguyen, Leyna Nguyen, Tracy Le, Egbert Madamba, Lisa Richards, Mark A. Valasek, Cynthia Behling, Claude B. Sirlin, Atsushi Nakajim
Alimentary Pharmacology & Therapeutics.2023; 58(2): 229. CrossRef
Changes in liver stiffness values assessed using transient elastography in chronic hepatitis B patients treated with tenofovir disoproxil fumarate: a prospective observational study
Heejin Cho, Yun Bin Lee, Yeonjung Ha, Young Eun Chon, Mi Na Kim, Joo Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang
BMC Gastroenterology.2023;[Epub] CrossRef
Metabolic dysfunction-associated fatty liver disease and the risk of hepatocellular carcinoma
Byeong Geun Song, Sung Chul Choi, Myung Ji Goh, Wonseok Kang, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Seung Woon Paik
JHEP Reports.2023; 5(9): 100810. CrossRef
Transient elastography with controlled attenuation parameter versus two-dimensional shear wave elastography with attenuation imaging for the evaluation of hepatic steatosis and fibrosis in NAFLD
Jung Wook Seo, Youe Ree Kim, Jong Keon Jang, So Yeon Kim, Young Youn Cho, Eun Sun Lee, Dong Ho Lee
Ultrasonography.2023; 42(3): 421. CrossRef
Serum resistin and the risk for hepatocellular carcinoma in diabetic patients
Mona Mohamed Ibrahim Abdalla
World Journal of Gastroenterology.2023; 29(27): 4271. CrossRef
Fibrotic Burden in the Liver Differs Across Metabolic Dysfunction-Associated Fatty Liver Disease Subtypes
Tae Seop Lim, Ho Soo Chun, Soon Sun Kim, Ja Kyung Kim, Minjong Lee, Hyo Jung Cho, Seung Up Kim, Jae Youn Cheong
Gut and Liver.2023; 17(4): 610. CrossRef
The correlation between NAFLD and serum uric acid to serum creatinine ratio
Jangwon Choi, Hyun Joe, Jung-Eun Oh, Yong-Jin Cho, Hwang-Sik Shin, Nam Hun Heo, Gulali Aktas
PLOS ONE.2023; 18(7): e0288666. CrossRef
Association between daily aspirin therapy and risk of hepatocellular carcinoma according to metabolic risk factor burden in non‐cirrhotic patients with chronic hepatitis B
Cheol‐Hyung Lee, Yun Bin Lee, Hyemi Moon, Jong‐Won Chung, Eun Ju Cho, Jeong‐Hoon Lee, Su Jong Yu, Yoon Jun Kim, Juneyoung Lee, Jung‐Hwan Yoon
Alimentary Pharmacology & Therapeutics.2023; 58(7): 704. CrossRef
Aerobic and Resistance Exercise: Synergistic Influence for Nonalcoholic Fatty Liver Disease
Ho Soo Chun
Gut and Liver.2023; 17(4): 485. CrossRef
KASL clinical practice guidelines for management of autoimmune hepatitis 2022

Clinical and Molecular Hepatology.2023; 29(3): 542. CrossRef
Comments on Relationship between the High Fatty Liver Index and Risk of Fracture: Reply
Min-Ji Kim, Jae-Hyung Roh, Jae-Han Jeon
Gut and Liver.2023; 17(4): 663. CrossRef
Regression of nonalcoholic fatty liver disease is associated with reduced risk of incident diabetes: A longitudinal cohort study
Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Sung Chul Choi, Yun Soo Hong, Yewan Park, Juhee Cho, Geum-Youn Gwak, Ahmed Mustafa Rashid
PLOS ONE.2023; 18(7): e0288820. CrossRef
Effect of 12-week intermittent calorie restriction compared to standard of care in patients with nonalcoholic fatty liver disease: a randomized controlled trial
Han Ah Lee, Hyeyoung Moon, Yuri Kim, Hye Ah Lee, Hwi Young Kim
Trials.2023;[Epub] CrossRef
Associations of Serum Uric Acid Level With Liver Enzymes, Nonalcoholic Fatty Liver Disease, and Liver Fibrosis in Korean Men and Women: A Cross-Sectional Study Using Nationally Representative Data
Jun Myong Lee, Hye Won Kim, So Young Heo, Kyung Yi Do, Jun Deok Lee, Seul Ki Han, Soon Koo Baik, Moon Young Kim, Sei-Jin Chang
Journal of Korean Medical Science.2023;[Epub] CrossRef
Statins for treatment of fatty liver disease: Recent advances
Xiao-Hui Fang, Cai-E Wang, Jiao Deng, Xing-Shun Qi
World Chinese Journal of Digestology.2023; 31(16): 659. CrossRef
MAFLD might be better in identifying subjects with sarcopenia or cardiovascular risk than NAFLD: A nationwide study
Eugene Han, Ho Soo Chun, Yong‐ho Lee, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Byung‐Wan Lee, Eun Seok Kang, Bong‐Soo Cha, Sang Hoon Ahn, Seung Up Kim
Journal of Gastroenterology and Hepatology.2023; 38(9): 1598. CrossRef
The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients
Magdi A. Ali, Eman El-Abd, Mohamed Morsi, Mohamed M. El Safwany, Mohamed Z. El-Sayed
European Journal of Hybrid Imaging.2023;[Epub] CrossRef
Critical appraisal of metabolic dysfunction-associated steatotic liver disease: Implication of Janus-faced modernity
Gi-Ae Kim, Joon Ho Moon, Won Kim
Clinical and Molecular Hepatology.2023; 29(4): 831. CrossRef
Real-World Epidemiology, Treatment Patterns, and Disease Burden of Chronic Hepatitis B and HDV Co-Infection in South Korea
Yuri Cho, SeongBeom Park, SeonYoung Park, WonJung Choi, Book Kim, Helin Han
Infectious Diseases and Therapy.2023; 12(10): 2387. CrossRef
Association between waist circumference trajectories and incident non-alcoholic fatty liver disease
Jun-Hyuk Lee, Soyoung Jeon, Hye Sun Lee, Yu-Jin Kwon
Obesity Research & Clinical Practice.2023; 17(5): 398. CrossRef
Overview and prospect of NAFLD: Significant roles of nutrients and dietary patterns in its progression or prevention
Tianyu Mao, Yiwen Sun, Xinyi Xu, Kang He
Hepatology Communications.2023;[Epub] CrossRef
Approach to Fatty Liver Disease in Patients with Type 2 Diabetes
Ji Cheol Bae
The Journal of Korean Diabetes.2023; 24(3): 107. CrossRef
Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating l-arginine production
Dong Yun Kim, Jun Yong Park, Heon Yung Gee
Experimental & Molecular Medicine.2023; 55(11): 2332. CrossRef
Magnetic resonance elastography-based prediction model for hepatic decompensation in NAFLD: A multicenter cohort study
Beom Kyung Kim, Jaclyn Bergstrom, Rohan Loomba, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem K. Oz, Ayse Erden, Emily Truong, Ju Dong Yang, Mazen Noureddin, Alina M. Allen, Rohit Loomba, Veeral Ajmera
Hepatology.2023; 78(6): 1858. CrossRef
Association between total body muscle percentage and prevalence of non-alcoholic fatty liver disease in Korean adults findings from an 18-year follow-up: a prospective cohort study
Byoung Chan Ahn, Chul Yong Park, Jung Hee Hong, Ki Ook Baek
Journal of Yeungnam Medical Science.2023; 40(Suppl): S47. CrossRef
The Association of Perfluoroalkyl Substance Exposure and a Serum Liver Function Marker in Korean Adults
Jisuk Yun, Soon-Chan Kwon
Toxics.2023; 11(12): 965. CrossRef
Alcohol consumption and the risk of liver disease: a nationwide, population-based study
Sang Yi Moon, Minkook Son, Yeo Wool Kang, Myeongseok Koh, Jong Yoon Lee, Yang Hyun Baek
Frontiers in Medicine.2023;[Epub] CrossRef
Lifestyle of patients with non-alcoholic fatty liver disease: assessment of dietary habits and physical activity
T.S. Krolevets, M.I. Syrovenko, M.A. Livzan
Russian Journal of Evidence-Based Gastroenterology.2023; 12(4): 43. CrossRef
Association of Hepatic Fat Deposition and Severity of Acanthosis Nigricans in Children and Adolescents with Obesity
Junhyung Lee, Hye-ji An, Young-Gyun Seo, Hong Ji Song, Hye-Mi Noh, Yu-Jin Paek, Kyung Hee Park
Korean Journal of Family Practice.2023; 13(4): 240. CrossRef
Advanced liver fibrosis measured by transient elastography predicts chronic kidney disease development in individuals with non-alcoholic fatty liver disease
Chan-Young Jung, Geun Woo Ryu, Hyung Woo Kim, Sang Hoon Ahn, Seung Up Kim, Beom Seok Kim
Diabetologia.2022; 65(3): 518. CrossRef
Long-term effects of the changes in hepatic steatosis status on the risk of incident type 2 diabetes mellitus: A 15-year community-based prospective cohort study
Seung Min Chung, Min Kyu Kang, Jinho Jung, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee, Rohit Loomba, Jung Gil Park, Jun Sung Moon
Diabetes Research and Clinical Practice.2022; 184: 109208. CrossRef
Benefit of Antiviral Therapy for HBV-Related HCC with Undetectable HBV DNA Is Still Dubious
Suprabhat Giri, Harish Darak, Sunil Kasturi
Digestive Diseases and Sciences.2022; 67(10): 4962. CrossRef
Gut Microbiome in Non-Alcoholic Fatty Liver Disease: From Mechanisms to Therapeutic Role
Haripriya Gupta, Byeong-Hyun Min, Raja Ganesan, Yoseph Asmelash Gebru, Satya Priya Sharma, Eunju Park, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Ji-Ye Hyun, Jung-A. Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Do
Biomedicines.2022; 10(3): 550. CrossRef
Aspirin use and risk of hepatocellular carcinoma in patients with chronic hepatitis B with or without cirrhosis
Heejoon Jang, Yun Bin Lee, Hyemi Moon, Jong‐Won Chung, Joon Yeul Nam, Eun Ju Cho, Jeong‐Hoon Lee, Su Jong Yu, Yoon Jun Kim, Juneyoung Lee, Jung‐Hwan Yoon
Hepatology.2022; 76(2): 492. CrossRef
The Phase 2 Study to Evaluate Efficacy and Safety of Lanifibranor in Patients with Nonalcoholic Steatohepatitis: Back in the Spotlight?
Sae Hwan Lee
The Korean Journal of Gastroenterology.2022; 79(3): 138. CrossRef
Metabolic dysfunction-associated fatty liver disease and risk of incident chronic kidney disease: A nationwide cohort study
Chan-Young Jung, Hee Byung Koh, Keun Hyung Park, Young Su Joo, Hyung Woo Kim, Sang Hoon Ahn, Jung Tak Park, Seung Up Kim
Diabetes & Metabolism.2022; 48(4): 101344. CrossRef
MAFLD enhances clinical practice for liver disease in the Asia-Pacific region
Takumi Kawaguchi, Tsubasa Tsutsumi, Dan Nakano, Mohammed Eslam, Jacob George, Takuji Torimura
Clinical and Molecular Hepatology.2022; 28(2): 150. CrossRef
PPAR-Targeted Therapies in the Treatment of Non-Alcoholic Fatty Liver Disease in Diabetic Patients
Naomi F. Lange, Vanessa Graf, Cyrielle Caussy, Jean-François Dufour
International Journal of Molecular Sciences.2022; 23(8): 4305. CrossRef
Prevalence trends of non-alcoholic fatty liver disease among young men in Korea: A Korean military population-based cross-sectional study
Jaejun Lee, Taeyun Kim, Hyun Yang, Si Hyun Bae
Clinical and Molecular Hepatology.2022; 28(2): 196. CrossRef
Recent Epidemiology and Risk Factors of Nonalcoholic Fatty Liver Disease
Youn Huh, Yoon Jeong Cho, Ga Eun Nam
Journal of Obesity & Metabolic Syndrome.2022; 31(1): 17. CrossRef
Gamma‐glutamyl transpeptidase dynamics as a biomarker for advanced fibrosis in non‐alcoholic fatty liver disease
Yeonjung Ha, Young Eun Chon, Mi Na Kim, Joo Ho Lee, Seong Gyu Hwang
Journal of Gastroenterology and Hepatology.2022; 37(8): 1624. CrossRef
The Importance of Metabolic Syndrome Status for the Risk of Non-Viral Hepatocellular Carcinoma: A Nationwide Population-Based Study
Yuri Cho, Eun Ju Cho, Jeong-Ju Yoo, Young Chang, Goh Eun Chung, In Young Choi, Sang-Hyun Park, Kyungdo Han, Yoon Jun Kim, Jung-Hwan Yoon, Dong Wook Shin, Su Jong Yu
Frontiers in Oncology.2022;[Epub] CrossRef
Association of Low Skeletal Muscle Mass with the Phenotype of Lean Non-Alcoholic Fatty Liver Disease
Jun-Hyeon Byeon, Min-Kyu Kang, Min-Cheol Kim
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Editorial

Hepatic neoplasm

Biopsy or cytology for diagnosing hepatic focal lesions?: Haeryoung Kim; Clin Mol Hepatol 2021;27(2):278-280.
Published online March 4, 2021; DOI: https://doi.org/10.3350/cmh.2021.0031

Citations

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Review

Liver fibrosis, cirrhosis, and portal hypertension

Histopathological evaluation of liver fibrosis and cirrhosis regression: Regina C. Lo, Haeryoung Kim; Clin Mol Hepatol 2017;23(4):302-307.
Published online December 20, 2017; DOI: https://doi.org/10.3350/cmh.2017.0078

Abstract
PDF

The hepatic repair complex in the setting of cirrhosis has received increasing attention, as it implies the regression of cirrhosis, which was traditionally taken to be an irreversible state. In this brief review, the patterns of fibrosis, the existing staging systems for chronic liver disease and the histopathological features of cirrhosis regression are discussed.

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Case Report

Benign liver tumors and cystic disease of liver

Living-donor liver transplantation for giant hepatic hemangioma with diffuse hemangiomatosis in an adult: a case report: Ju Hyun Lee, Chang Jin Yoon, Young Hoon Kim, Ho-Seong Han, Jai Young Cho, Haeryoung Kim, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong; Clin Mol Hepatol 2018;24(2):163-168.
Published online July 19, 2017; DOI: https://doi.org/10.3350/cmh.2017.0002

Abstract
PDF

Hepatic hemangioma represents the most common benign primary hepatic neoplasm. Although most such tumors are small and asymptomatic, giant hepatic hemangioma is frequently symptomatic, and requires intervention. Moreover, diffuse multiple hepatic hemangiomatosis occupying almost the entire liver is extremely rare in adults, and the optimal management for this condition is unclear. We report a case of a rapidly growing, symptomatic giant hepatic hemangioma with diffuse hepatic hemangiomatosis in a 50-year-old female patient who was treated by living-donor liver transplantation. This case shows malignant behavior of a benign hemangioma that required liver transplantation. Although this case could not meet the criteria for transplantation according to the MELD (model for end-stage liver disease) score system, it should be considered as an exceptional indication for deceased-donor liver allocation. Further studies of the mechanism underlying hemangioma growth are warranted.

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Liver Pathologys

Hepatic neoplasm

Sarcomatoid cholangiocarcinoma with osteoclast-like giant cells associated with hepatolithiasis: A case report: Hye Min Kim, Haeryoung Kim, Young Nyun Park; Clin Mol Hepatol 2015;21(3):309-313.
Published online September 30, 2015; DOI: https://doi.org/10.3350/cmh.2015.21.3.309

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Case Report

Coinfection of hepatitis A virus genotype IA and IIIA complicated with autoimmune hemolytic anemia, prolonged cholestasis, and false-positive immunoglobulin M anti-hepatitis E virus: a case report: Hee-Sup Kim, Sook-Hyang Jeong, Je-Hyuck Jang, Hyung-Joon Myung, Jin-Wook Kim, Soo-Mee Bang, Sang Hoon Song, Haeryoung Kim, Hae Sun Yun; Korean J Hepatol 2011;17(4):323-327.
Published online December 26, 2011; DOI: https://doi.org/10.3350/kjhep.2011.17.4.323

Abstract
PDF

A 37-year-old male presented with fever and jaundice was diagnosed as hepatitis A complicated with progressive cholestasis and severe autoimmune hemolytic anemia. He was treated with high-dose prednisolone (1.5 mg/kg), and eventually recovered. His initial serum contained genotype IA hepatitis A virus (HAV), which was subsequently replaced by genotype IIIA HAV. Moreover, at the time of development of hemolytic anemia, he became positive for immunoglobulin M (IgM) anti-hepatitis E virus (HEV). We detected HAV antigens in the liver biopsy specimen, while we detected neither HEV antigen in the liver nor HEV RNA in his serum. This is the first report of hepatitis A coinfected with two different genotypes manifesting with autoimmune hemolytic anemia, prolonged cholestasis, and false-positive IgM anti-HEV.

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Liver Pathologys

IgG4-related sclerosing cholangitis: liver biopsy findings: Han Suk Ryu, Haeryoung Kim; Korean J Hepatol 2011;17(1):76-79.
Published online March 21, 2011; DOI: https://doi.org/10.3350/kjhep.2011.17.1.76

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Massive hepatic necrosis with large regenerative nodules: Haeryoung Kim, Young Nyun Park; Korean J Hepatol 2010;16(3):334-337.
Published online September 30, 2010; DOI: https://doi.org/10.3350/kjhep.2010.16.3.334

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