Joseph Rabbat, Boyu Yang, Hye Won Lee, Huapeng Lin, Emmanuel Tsochatzis, Salvatore Petta, Elisabetta Bugianesi, Masato Yoneda, Ming-Hua Zheng, Hannes Hagström, Jérôme Boursier, José Luis Calleja, George Boon-Bee Goh, Wah-Kheong Chan, Rocio Gallego-Durán, Arun J. Sanyal, Victor de Lédinghen, Philip N Newsome, Jian-Gao Fan, Laurent Castéra, Michelle Lai, Céline Fournier-Poizat, Grace Lai-Hung Wong, Mirko Zoncape, Grazia Pennisi, Angelo Armandi, Atsushi Nakajima, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop, Kevin Kim Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Mandy Sau-Wai Chan, Clemence M Canivet, Manuel Romero-Gomez, Vincent Wai-Sun Wong, Seung Up Kim, Terry Cheuk-Fung Yip
Clin Mol Hepatol 2026;32(1):289-304. Published online November 11, 2025
Background/Aims Current guidelines recommend a 2-step approach for identifying advanced fibrosis in metabolic dysfunction-associated steatotic liver disease (MASLD), using Fibrosis-4 index (FIB-4) followed by liver stiffness measurement (LSM) via vibration-controlled transient elastography (VCTE). However, some patients may exhibit discordant results. This study evaluates the histological severity and outcomes in patients with discordant FIB-4 and LSM results.
Methods This secondary analysis of the VCTE-Prognosis study included 12,950 patients evaluated for MASLD at 16 tertiary centers, of whom 2,915 underwent liver biopsy. Patients were categorized into four groups based on established FIB-4 (1.3) and LSM (8 kPa) cutoffs.
Results F3–F4 fibrosis was observed in 6.4%, 13.7%, 30.6%, and 62.4% in low-FIB-4-low-LSM (n=6,403), high-FIB-4-low-LSM (n=3,017), low-FIB-4-high-LSM (n=1,363), and high-FIB-4-high-LSM (n=2,167) groups, respectively. During a median follow-up of 47.4 months, 248 patients experienced hepatic decompensation, hepatocellular carcinoma, liver transplantation, or liver-related death. The incidence rates of liver-related events (LREs) were 0.67, 1.19, 2.58, and 21.30 per 1,000 person-years, respectively. Compared to low-FIB-4-low-LSM patients, those with low-FIB-4-high-LSM (adjusted subdistribution hazard ratio [aSHR] 4.12) and high-FIB-4-high-LSM (aSHR 21.38) had a significantly higher risk of LREs, while high-FIB-4-low-LSM patients did not. Similar findings were observed when hepatic decompensation and hepatocellular carcinoma were analyzed separately.
Conclusions Approximately 30% of patients in tertiary centers exhibit discordant FIB-4 and LSM results, with LSM more likely reflecting true severity. While some patients with discordant results may have advanced fibrosis, the overall incidence of LREs remains low.
Citations
Citations to this article as recorded by
Are FIB-4 and liver stiffness measurement interchangeable for HCC risk stratification in MASLD? Yimeng Zhou, Xue Meng JHEP Reports.2026; : 101852. CrossRef
High Prevalence of Metabolic Dysfunction–Associated Steatohepatitis With Significant Fibrosis in Primary Care and Endocrinology Clinics Srilaxmi Kalavalapalli, Eddison Godinez Leiva, Andrea Ortiz Rocha, Anu Sharma, Diana Barb, Nathaly Cuervo‐Pardo, Kelly Y. Chun, Toni R. Prezant, Margery A. Connelly, Jens T. Rosenberg, Joseph R. Grajo, Fernando Bril, Kenneth Cusi Diabetes, Obesity and Metabolism.2026;[Epub] CrossRef
Comparative Risk of Hepatitis B Virus Reactivation in Patients Receiving Immune Checkpoint Inhibitors or Tyrosine Kinase Inhibitors for Liver Cancer Dorothy Cheuk‐Yan Yiu, Jimmy Che‐To Lai, Landon Long Chan, Grace Lai‐Hung Wong, Mandy Sze‐Man Lai, Vincent Wai‐Sun Wong, Yee‐Kit Tse, Henry Lik‐Yuen Chan, Stephen Lam Chan, Terry Cheuk‐Fung Yip Alimentary Pharmacology & Therapeutics.2026; 63(3): 383. CrossRef
Prognostic Impact of DPP4 Inhibitors on Systemic Drug Therapy for Advanced Kidney Cancer Patients Shuhei Kamada, Sachi Kitayama, Ryosuke Yamase, Kazuhiro Ikeda, Wataru Sato, Tomokazu Sazuka, Hideki Takeshita, Shinichi Sakamoto, Akihiro Yano, Kuniko Horie, Tomohiko Ichikawa, Satoru Kawakami, Satoshi Inoue Cancer Science.2026; 117(2): 468. CrossRef
Click inspired new series of pyridazine-triazole-persulfonimide derivatives as DPP-4 inhibitors with exploratory HepG2 phenotypic screening Manisha Nidhar, Vipin Kumar, Sooraj Sura, Abdulah Jarboa Alqahtani, Harish C. Chandramoorthy, A. Rekha, Gaurav Gupta, Aswathy R. Devan, Lekshmi R. Nath, Ashish Kumar Tewari Bioorganic Chemistry.2026; 176: 109853. CrossRef
CXCL12 as a Potential Hub Gene for N-Acetylcysteine Treatment of T1DM Liver Disease Menglong Zhao, Mingzheng Han, Shuaihao Guo, Zhaoxin Tang Biomolecules.2025; 15(2): 176. CrossRef
Inflammation is the key driver of liver fibrosis progression in non-alcoholic fatty liver disease (NAFLD). Unfortunately, it is often challenging to assess inflammation in NAFLD due to its dynamic nature and poor correlation with liver biochemical markers. Liver histology keeps its role as the standard tool, yet it is well-known for substantial sampling, intraobserver, and interobserver variability. Serum proinflammatory cytokines and apoptotic markers, namely cytokeratin-18, are well-studied with reasonable accuracy, whereas serum metabolomics and lipidomics have been adopted in some commercially available diagnostic models. Ultrasound and computed tomography imaging techniques are attractive due to their wide availability; yet their accuracies may not be comparable with magnetic resonance imaging-based tools. Machine learning and deep learning models, be they supervised or unsupervised learning, are promising tools to identify various subtypes of NAFLD, including those with dominating liver inflammation, contributing to sustainable care pathways for NAFLD.
Citations
Citations to this article as recorded by
Deep learning-based automated detection of endometrioid endometrial carcinoma in histopathology Ruotong Li, Kunyu Zou, Qihang Ma, Yaping Liu, Xiaohui Wang, Wenbin Huang, Shegan Gao, Xueying Yang Frontiers in Oncology.2026;[Epub] CrossRef
Diagnostic Performance of Shear-Wave Dispersion Slope for Biopsy-Proven Hepatic Inflammation in MASLD: A Systematic Review and HSROC Meta-Analysis Caixin Qiu, Meina Cai, Lulu Lyu, Peng Xu Ultrasound in Medicine & Biology.2026; 52(5): 916. CrossRef
ROS-Responsive Prodrug Containing Dihydroartemisinin and Cinnamaldehyde for the Potential Treatment of Nonalcoholic Steatohepatitis Ru Hao, Yi Sun, Changyuan Wang, Yang Wang, Lei Li, Huijun Sun, Lixue Chen ACS Applied Materials & Interfaces.2026; 18(9): 13384. CrossRef
Potential Drug Targets and Causal Plasma Proteins Related to Preeclampsia Identified by Mendelian Randomization Wei Zhou, Ting Huang, Lei Li, Yanli Shen, Zhe Ji, Meng Yan Women's Health Reports.2026;[Epub] CrossRef
Clinical Integration of Novel Non‐Invasive Biomarkers in Hepatology: Bridging Statistical Promise and Bedside Utility F. N. U. Mehrish, Talha Khan, Mujtaba Moazzam Journal of Gastroenterology and Hepatology.2026;[Epub] CrossRef
Chronic exposure to environmentally relevant Bisphenol F induces hepatic injury and inflammation in Zebrafish Yuehong Shen, Dingyu Zhou, Tong Wei, Tuantuan Lei, Yuanhui Zhu, Mengyuan Liang, Junjie Sun, Peng Wang, Guixiang Ji, Jie Gu, Han Gao, Wenzhu Wu Aquatic Toxicology.2026; 296: 107825. CrossRef
MAST versus FAST for active fibrotic MASH: a meta-analysis supporting risk-stratified diagnostic pathways Shengfang Liu, Qingjuan Zhang, Lijing Wang, Qin Tang, Bingtao Hu Frontiers in Medicine.2026;[Epub] CrossRef
Association between neutrophil-albumin ratio and ultrasound-defined metabolic dysfunction-associated fatty liver disease in U.S. adults: evidence from NHANES 2017–2018 Ming-yu He, Xin-jie Du, Yi-ming Liu BMC Gastroenterology.2025;[Epub] CrossRef
Validation of the diagnostic accuracy of the acFibroMASH index for at-risk MASH in patients with metabolic dysfunction-associated steatotic liver disease Yunfei Wu, Yan Han, Liming Zheng, Longgen Liu, Wenjian Li, Fan Zhang BMC Gastroenterology.2025;[Epub] CrossRef
Diagnostic Value of Serum Cytokeratin 18 for the Staging of Liver Inflammation and Fibrosis: A Meta‐Analysis Jinwen Chen, Jian Hu, Jialin Zhuang, Zhong Li, Se Peng, Xiaoting Huang, Jialing Zhuang Journal of Clinical Laboratory Analysis.2025;[Epub] CrossRef
Obesity: pathophysiology and therapeutic interventions Yue Kong, Haokun Yang, Rong Nie, Xuxiang Zhang, Fan Zuo, Hongtao Zhang, Xin Nian Molecular Biomedicine.2025;[Epub] CrossRef
The advanced lung cancer inflammation index has an L-shaped association with prognosis in American adults with metabolic dysfunction-associated fatty liver disease: a cohort study Yuexia Lu, Shuaipeng Yuan, Huazhao Xu, Jiqi Ouyang, Jinsheng Dong, Xin Jiang, Xiao Shao, Runshun Zhang Frontiers in Nutrition.2025;[Epub] CrossRef
Global Trends in Non-Invasive Techniques for the Diagnosis and Monitoring of Nonalcoholic Fatty Liver Disease: A Bibliometric and Visualization Analysis Jing-Wen Cai, Wei-Long Wang, Dong-Ling Lin, Shu-Feng Ren, Qian-Qian Jia, Xiao-Xuan He, Xue-Xia Yang, Wen Cai, Hui Hou Journal of Multidisciplinary Healthcare.2025; Volume 18: 4243. CrossRef
Gradual DNA methylation changes reveal transcription factors implicated in metabolic dysfunction-associated steatotic liver disease progression and epigenetic age acceleration Evelien Van Dijck, Steven Van Laere, Emilie Logie, Steven Timmermans, Erik Fransen, Joe Ibrahim, Timothy J. Kendall, Jonathan A. Fallowfield, Ligia M. Mateiu, Claude Libert, Guy Van Camp, An Verrijken, Luc Van Gaal, Sven Francque, Wim Van Hul, Wim Vanden Clinical Epigenetics.2025;[Epub] CrossRef
Quantification of 18F-FDG Delivery Rate for Liver Inflammation Using Shortened Dynamic PET Imaging Protocols Xiaoyu Duan, Souvik Sarkar, Victoria Lyo, Sean Romeo, Benjamin A. Spencer, Karen E. Matsukuma, Valentina Medici, Michael T. Corwin, Ramsey D. Badawi, Guobao Wang Journal of Nuclear Medicine.2025; 66(11): 1834. CrossRef
ChatGPT improves usability, effectiveness, scalability, interpretability and accessibility, in early diagnosis of metabolic dysfunction-associated fatty liver disease Xiaoying Zhou, Zhipeng Gao, Han Ma, Jiahui Hu, Chengfu Xu, Zhe Shen, Miaomiao Tan, Chaohui Yu BMC Gastroenterology.2025;[Epub] CrossRef
Low liver fat in non‐alcoholic steatohepatitis‐related significant fibrosis and cirrhosis is associated with hepatocellular carcinoma, decompensation and mortality Sung Won Lee, Daniel Q. Huang, Ricki Bettencourt, Veeral Ajmera, Monica Tincopa, Nabil Noureddin, Maral Amangurbanova, Harris Siddiqi, Egbert Madamba, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Masato Yoneda, Ramzan I Alimentary Pharmacology & Therapeutics.2024; 59(1): 80. CrossRef
Neither hepatic steatosis nor fibrosis is associated with clinical outcomes in patients with intestinal Behçet’s disease Hye Kyung Hyun, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon European Journal of Gastroenterology & Hepatology.2024; 36(4): 445. CrossRef
Evolutive Models, Algorithms and Predictive Parameters for the Progression of Hepatic Steatosis Marinela Sînziana Tudor, Veronica Gheorman, Georgiana-Mihaela Simeanu, Adrian Dobrinescu, Vlad Pădureanu, Venera Cristina Dinescu, Mircea-Cătălin Forțofoiu Metabolites.2024; 14(4): 198. CrossRef
Editorial: Inflammation and chronic disease Frank A. Orlando, Arch G. Mainous Frontiers in Medicine.2024;[Epub] CrossRef
Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis Shaofang Chen, Danping Zhuang, Qingyun Jia, Bing Guo, Genwen Hu Biomaterials Research.2024;[Epub] CrossRef
Serum Cytokeratin-18 levels as a prognostic biomarker in advanced liver disease: a comprehensive meta-analysis Xin Zhang, Jiangguo Li, Li Jiang, Yuexia Deng, Licheng Wei, Xing Li Clinical and Experimental Medicine.2024;[Epub] CrossRef
The Metabolomic Footprint of Liver Fibrosis Diren Beyoğlu, Yury V. Popov, Jeffrey R. Idle Cells.2024; 13(16): 1333. CrossRef
Machine learning based identification potential feature genes for prediction of drug efficacy in nonalcoholic steatohepatitis animal model Marwa Matboli, Ibrahim Abdelbaky, Abdelrahman Khaled, Radwa Khaled, Shaimaa Hamady, Laila M. Farid, Mariam B. Abouelkhair, Noha E. El-Attar, Mohamed Farag Fathallah, Manal S. Abd EL Hamid, Gena M. Elmakromy, Marwa Ali Lipids in Health and Disease.2024;[Epub] CrossRef
Structure-function analysis of time-resolved immunological phases in metabolic dysfunction-associated fatty liver disease (MASH) comparing the NIF mouse model to human MASH Anja Schmidt-Christensen, Gustaw Eriksson, William M. Laprade, Behnaz Pirzamanbein, Maria Hörnberg, Kajsa Linde, Julia Nilsson, Mark Skarsfeldt, Diana J. Leeming, Rajmund Mokso, Mariana Verezhak, Anders Dahl, Vedrana Dahl, Kristina Önnerhag, Massoud Rezae Scientific Reports.2024;[Epub] CrossRef
Polygala japonica Houtt.: A comprehensive review on its botany, traditional uses, phytochemistry, pharmacology, and pharmacokinetics Hai-Peng Tang, En-Lin Zhu, Qian-Xiang Bai, Shuang Wang, Zhi-Bin Wang, Meng Wang, Hai-Xue Kuang Fitoterapia.2024; 179: 106233. CrossRef
Chondroitin Sulfate from Halaelurus burgeri Skin Inhibits Hepatic Endoplasmic Reticulum Stress and Inflammation, and Regulates Gut Microbiota Zhaocai Ren, Shang Gao, Shiwei Hu, Sichun Chen, Wei Jiang, Yaming Ge Molecular Nutrition & Food Research.2024;[Epub] CrossRef
Serum Cytokeratin 18 Fragment Is an Indicator for Treating Metabolic Dysfunction-Associated Steatotic Liver Disease Miwa Kawanaka, Yoshihiro Kamada, Hirokazu Takahashi, Michihiro Iwaki, Ken Nishino, Wenli Zhao, Yuya Seko, Masato Yoneda, Yoshihito Kubotsu, Hideki Fujii, Yoshio Sumida, Hirofumi Kawamoto, Yoshito Itoh, Atsushi Nakajima, Takeshi Okanoue, Takumi Kawaguchi, Gastro Hep Advances.2024; 3(8): 1120. CrossRef
Metabolomic Hallmarks of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease Diren Beyoğlu, Yury V. Popov, Jeffrey R. Idle International Journal of Molecular Sciences.2024; 25(23): 12809. CrossRef
MASLD: predictive value for liver-related events and extra-hepatic complications Mohamad Jamalinia, Amedeo Lonardo Expert Review of Gastroenterology & Hepatology.2024; 18(11): 685. CrossRef
Baseline Tyrosine Level Is Associated with Dynamic Changes in FAST Score in NAFLD Patients under Lifestyle Modification Hwi Young Kim, Da Jung Kim, Hye Ah Lee, Joo-Youn Cho, Won Kim Metabolites.2023; 13(3): 444. CrossRef
Prospective direct comparison of non‐invasive liver tests in outpatients with type 2 diabetes using intention‐to‐diagnose analysis Thierry Poynard, Olivier Deckmyn, Valentina Peta, Valérie Paradis, Jean‐Francois Gautier, Angélique Brzustowski, Pierre Bedossa, Laurent Castera, Stanislas Pol, Dominique Valla Alimentary Pharmacology & Therapeutics.2023; 58(9): 888. CrossRef
Huapeng Lin, Grace Lai-Hung Wong, Xinrong Zhang, Terry Cheuk-Fung Yip, Ken Liu, Yee Kit Tse, Vicki Wing-Ki Hui, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Vincent Wai-Sun Wong
Clin Mol Hepatol 2022;28(1):77-90. Published online November 5, 2021
Background/Aims We aimed to determine the association between blood urea level and incident cirrhosis, hepatic decompensation, and hepatocellular carcinoma in chronic liver disease (CLD) patients.
Methods The association between blood urea level and liver fibrosis/liver-related events were evaluated on continuous scale with restricted cubic spline curves based on generalized additive model or Cox proportional hazards models. Then, the above associations were evaluated by urea level within intervals.
Results Among 4,282 patients who had undergone liver stiffness measurement (LSM) by transient elastography, baseline urea level had a U-shaped association with LSM and hepatic decompensation development after a median follow-up of 5.5 years. Compared to patients with urea of 3.6–9.9 mmol/L, those with urea ≤3.5 mmol/L (adjusted hazard ratio [aHR], 4.15; 95% confidence interval [CI], 1.68–10.24) and ≥10 mmol/L (aHR, 5.22; 95% CI, 1.86–14.67) had higher risk of hepatic decompensation. Patients with urea ≤3.5 mmol/L also had higher risk of incident cirrhosis (aHR, 3.24; 95% CI, 1.50–6.98). The association between low urea level and incident cirrhosis and hepatic decompensation was consistently observed in subgroups by age, gender, albumin level, and comorbidities. The U-shaped relationship between urea level and LSM was validated in another population screening study (n=917). Likewise, urea ≤3.5 mmol/L was associated with a higher risk of incident cirrhosis in a territory-wide cohort of 12,476 patients with nonalcoholic fatty liver disease at a median follow-up of 9.9 years (aHR, 1.27; 95% CI, 1.03–1.57).
Conclusions We identified a U-shaped relationship between the urea level and liver fibrosis/incident cirrhosis/hepatic decompensation in patients with CLD.
Citations
Citations to this article as recorded by
An RFH-NPT-based nomogram for predicting the long-term survival of liver cirrhosis patients: a multicenter study Chengbin Zhu, Yuchao Wu, Fulian Zhao, Ruojing Wang, Qijuan Zang, Zhe Jiao, Yage Zhu, Taotao Yan, Juan Du, Li Zhu, Weimin Li, Yongqin Li, Qing Fan, Anping Wu, Xiaodan Liu, Dianzu Liu, Xianmei Tang, Xiaoxiao Xu, Huaying Liao, Yu Li, Yingren Zhao, Yingli He, European Journal of Clinical Nutrition.2026; 80(1): 87. CrossRef
Advances in Electrochemical Urea Biosensors: Trends and Future Prospects Samar Shurbaji, Arshad Khan, Mohammad K. Hassan, Amine Bermak, Wen‐Di Li, Kabir H Biswas, Bo Wang Advanced Sensor Research.2026;[Epub] CrossRef
A dual-purpose paper-based electrochemical device for enzyme-free sensing of urinary urea and micro-powering applications: towards self-powered electrochemical sensors Madhuvallika Sreekonda, Sohel Samad Chaus, Sweta Lal Microchemical Journal.2026; 225: 118076. CrossRef
Preclinical studies on the antitumor and non‐toxic effect of combining pirfenidone with vinorelbine and carboplatin in non‐small cell lung cancer Helena Branco, Catarina A. Rodrigues, Júlio Oliveira, Nuno Mendes, Catarina Antunes, Irina Amorim, Lúcio L. Santos, M. Helena Vasconcelos, Cristina P. R. Xavier International Journal of Cancer.2025; 156(9): 1756. CrossRef
Phase-dependent hepatotoxicity of Aluminum oxide nanoparticles mediated through the intestinal microbiota Mingshu Li, Fuchang Deng, Li Dong, Xiaona Wang, Haiyan Jiang, Siyu Yao, Yuanyuan Chen, Lian Duan, Huamao Du, Guangqiu Qin, Song Tang Environment International.2025; 198: 109398. CrossRef
Parenclitic network mapping predicts survival in critically ill patients with sepsis Emily Ito, Tope Oyelade, Matthew Wikner, Jinyuan Liu, Watjana Lilaonitkul, Ali R. Mani Physiological Reports.2025;[Epub] CrossRef
The role of urea in pathological conditions O.B. Kvasnytska, A.I. Gozhenko, D.D. Ivanov, O.O. Popadynets KIDNEYS.2025; 14(3): 251. CrossRef
Colchicine induces developmental defects and renal toxicity in zebrafish by upregulating the oxidative stress Fang Chen, Haiyan Wei, Dalong Liao, Yong Huang, Yijian Chen, Huiqiang Lu, Rong Xu Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology.2025; 298: 110328. CrossRef
Neurological alterations in adult female rats developmentally exposed to a glyphosate-based herbicide: Potential role of the immune system Cristina Eugenia Gallegos, Mariana Bartos, Fernanda Gumilar, Diego Nicolás Nabaes Jodar, Ileana Lencinas, Cristina Bras, Betina Noemí García, Jorge Andrés Delbés, Sergio Dominguez, Carlos Javier Baier Toxicology.2025; 518: 154279. CrossRef
Inverse Association Between METS-IR and Lung Cancer Risk: The Role of BMI in a Nationwide Korean Cohort Bo-Kyung Shine, In Hwa Jeong, Minkook Son, Bongjo Kim, Sang Yi Moon, Jong Yoon Lee, Hye Ryeon Kim, Seok Jae Huh Cancers.2025; 17(23): 3727. CrossRef
ULTRASONOGRAPHIC INDICATORS OF THE KIDNEYS IN COMBINED LIVER AND KIDNEY PATHOLOGY IN DOGS V. Rudyashko Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology.2025; 26(2): 216. CrossRef
Cross-sectional and longitudinal associations between fatty liver index and kidney function using updated MASLD and CKD–EPI 2021 definitions: a population-based study with region-specific cutoffs Sina Bazmi, Mohammadreza Fardaei, Reza Homayounfar, Maryam Kazemi, Babak Pezeshki, Reza Malekzadeh, Nasrollah Ghahramani, Mojtaba Farjam European Journal of Medical Research.2025;[Epub] CrossRef
Comparison of Engineered Liver 3D Models and the Role of Oxygenation for Patient‐Derived Tumor Cells and Immortalized Cell Lines Cocultured with Tumor Stroma in the Detection of Hepatotoxins Mona Mansouri, Astha Lamichhane, Dola Das, Federico Aucejo, Hossein Tavana, Nic D. Leipzig Advanced Biology.2024;[Epub] CrossRef
The Role and Limitations of the Reference Interval Within Clinical Chemistry and Its Reliability for Disease Detection Nathan E. Timbrell British Journal of Biomedical Science.2024;[Epub] CrossRef
The Role of Interleukin-6 and Procalcitonin in Kidney Patients have Bacterial and Viral Infection Anwar Aiad Gaber, Jawad Kadhum Muraih Biomedical and Pharmacology Journal.2024; 17(1): 461. CrossRef
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats Serdar Vanli, Firuze Kurtoglu, Beyza S. Alan, Gokhan Akcakavak, Ozgur Ozdemir Toxicology Mechanisms and Methods.2024; 34(7): 750. CrossRef
Association of blood urea nitrogen with all-cause and cardiovascular mortality in hyperlipidemia: NHANES 1999–2018 Jing Shen, Zhen Wang, Yong Liu, Tao Wang, Xiao-Yu Wang, Xin-Hui Qu, Zhi-Ping Chen, Xiao-Jian Han Lipids in Health and Disease.2024;[Epub] CrossRef
Association between serum vitamin D status and severity of liver cirrhosis: implications for therapeutic targeting in Nigerian patients Winnifred Njideka Adiri, Bruno Basil, Chinwe Philomena Onyia, Promise Asogwa, Oluchi Joy Ugwuanyi, Olive Obienu, Uchenna Nkemdilim Ijoma, Slyvester Chuks Nwokediuko BMC Gastroenterology.2024;[Epub] CrossRef
Age and the relative importance of liver‐related deaths in nonalcoholic fatty liver disease Huapeng Lin, Terry Cheuk‐Fung Yip, Xinrong Zhang, Guanlin Li, Yee‐Kit Tse, Vicki Wing‐Ki Hui, Lilian Yan Liang, Jimmy Che‐To Lai, Stephen Lam Chan, Henry Lik‐Yuen Chan, Grace Lai‐Hung Wong, Vincent Wai‐Sun Wong Hepatology.2023; 77(2): 573. CrossRef
Trends in risk factor control and treatment among patients with non‐alcoholic fatty liver disease and type 2 diabetes between 2000 and 2020: A territory‐wide study Xinrong Zhang, Terry Cheuk‐Fung Yip, Yee‐Kit Tse, Vicki Wing‐Ki Hui, Guanlin Li, Huapeng Lin, Lilian Yan Liang, Jimmy Che‐To Lai, Mandy Sze‐Man Lai, Johnny T. K. Cheung, Henry Lik‐Yuen Chan, Stephen Lam Chan, Alice Pik‐Shan Kong, Grace Lai‐Hung Wong, Vinc Alimentary Pharmacology & Therapeutics.2023; 57(10): 1103. CrossRef
Effects of the in-utero dicyclohexyl phthalate and di-n-hexyl phthalate administration on the oxidative stress-induced histopathological changes in the rat liver tissue correlated with serum biochemistry and hematological parameters Duygu Aydemir, Mufide Aydogan-Ahbab, Nurhayat Barlas, Nuriye Nuray Ulusu Frontiers in Endocrinology.2023;[Epub] CrossRef
A comparative multi-level toxicity assessment of carbon-based Gd-free dots and Gd-doped nanohybrids from coffee waste: hematology, biochemistry, histopathology and neurobiology study Halyna Kuznietsova, Natalia Dziubenko, Konstantin Paliienko, Natalia Pozdnyakova, Natalia Krisanova, Artem Pastukhov, Tetiana Lysenko, Marina Dudarenko, Valeriy Skryshevsky, Vladimir Lysenko, Tatiana Borisova Scientific Reports.2023;[Epub] CrossRef
Alcohol consumption and the risk of liver disease: a nationwide, population-based study Sang Yi Moon, Minkook Son, Yeo Wool Kang, Myeongseok Koh, Jong Yoon Lee, Yang Hyun Baek Frontiers in Medicine.2023;[Epub] CrossRef
Effects of 4G mobile phone radiation exposure on reproductive, hepatic, renal, and hematological parameters of male Wistar rat Rohit Gautam, Sonali Pardhiya, Jay Prakash Nirala, Priyanka Sarsaiya, Paulraj Rajamani Environmental Science and Pollution Research.2023; 31(3): 4384. CrossRef
Is lean non-alcoholic fatty liver disease a distinct entity? Huapeng Lin, Vincent Wai-Sun Wong Hepatology International.2022; 16(2): 254. CrossRef
Reply to: Blood urea better than creatinine in prognosticating post‐TIPS outcomes: Hope or hype? Luisa Fürschuß, Florian Rainer, Angela Horvath, Vanessa Stadlbauer Liver International.2022; 42(7): 1702. CrossRef
Blood urea better than creatinine in prognosticating post‐TIPS outcomes: Hope or hype? Suprabhat Giri, Shivaraj Afzalpurkar, Sunil Kasturi, Dhiraj Agrawal Liver International.2022; 42(7): 1700. CrossRef
Screening and prediction of nonalcoholic fatty liver disease using a peripheral insulin resistance index: Potential benefits and limitations Soon Sun Kim, Jae Youn Cheong Clinical and Molecular Hepatology.2022; 28(4): 802. CrossRef
First
Prev
