Skip to main navigation Skip to main content

Clin Mol Hepatol : Clinical and Molecular Hepatology

OPEN ACCESS
ABOUT
BROWSE ARTICLES
FOR CONTRIBUTORS

Page Path

1
results for

"Kyoung Hwan Seol"

Keywords

Publication year

"Kyoung Hwan Seol"

Original Article
Development and validation of a simple index system to predict nonalcoholic fatty liver disease
Young Jin Park, Jie Hyang Lim, Eun Ryoung Kwon, Hee Kyoung Kim, Myoung Chul Jung, Kyoung Hwan Seol, Woo Yong Noh, Na Eun Kim
Korean J Hepatol 2011;17(1):19-26.
Published online March 21, 2011
DOI: https://doi.org/10.3350/kjhep.2011.17.1.19
Background/Aims

Abdominal ultrasonography is useful for the detection and diagnosis of nonalcoholic fatty liver disease (NAFLD). The aims of this study were to establish a predictive model for the selection of subjects for abdominal ultrasonography for the diagnosis of NAFLD and to assess validity of the model.

Methods

The subjects included 901 people who visited the health examination center of the Busan Medical Center. We conducted multiple logistic regression analyses of potential risk factors to identify independent risk factors for NAFLD, and developed an index system.

Results

Four independent risk factors were identified. The index system was developed by assigning 1 clinical scoring point to approximately 0.7 logistic regression coefficients to each factor as follows: alanine aminotransferase/aspartate aminotransferase ratio >1.5 (odds ratio [OR], 2.22; 95% confidence interval [CI], 1.21-4.07; P=0.010), 1 point; γ-glutamyl transpeptidase >50 (OR, 2.15; 95% CI, 1.13-4.07; P=0.019), 1 point; triglyceride >150 mg/dL (OR, 1.92; 95% CI, 1.14-3.24; P=0.015), 1 point; 23 kg/m2≤BMI<25 kg/m2 (OR, 3.68; 95% CI, 2.05-6.63; P<0.001), 2 points; and BMI 25 kg/m2 (OR, 7.65; 95% CI, 4.29-13.62; P<0.001), 3 points. The area under the receiver operating characteristics curve was 0.797 (95% CI, 0.751-0.842), and when 3 points was used as a cut-off value, the sensitivity and specificity were 71.7% and 75.9%, respectively.

Conclusions

NAFLD can be predicted through the clinical application of the index system established herein. If abdominal ultrasonography is used for high-risk patients, NAFLD will be diagnosed and managed in its early stage.

Citations

Citations to this article as recorded by  Crossref logo
  • Evaluation of ten diagnostic models for metabolic dysfunction-associated fatty liver disease in lean people living with HIV
    Wei Xu, Danping Liu, Renfang Zhang, Jun Chen, Yinzhong Shen
    BMC Infectious Diseases.2025;[Epub]     CrossRef
  • Prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in a middle-aged population with overweight and normal liver enzymes, and diagnostic accuracy of noninvasive proxies
    K.C. van Son, L.C. te Nijenhuis-Noort, S.C. Boone, D.O. Mook-Kanamori, A.G. Holleboom, P.R. Roos, H.J. Lamb, G. Alblas, M.J. Coenraad, F.R. Rosendaal, R. de Mutsert, M.E. Tushuizen
    Medicine.2024; 103(1): e34934.     CrossRef
  • Automated machine learning models for nonalcoholic fatty liver disease assessed by controlled attenuation parameter from the NHANES 2017–2020
    Lihe Liu, Jiaxi Lin, Lu Liu, Jingwen Gao, Guoting Xu, Minyue Yin, Xiaolin Liu, Airong Wu, Jinzhou Zhu
    DIGITAL HEALTH.2024;[Epub]     CrossRef
  • Diagnostic accuracy of blood biomarkers and non-invasive scores for the diagnosis of NAFLD and NASH: Systematic review and meta-analysis
    Daniela Contreras, Alejandra González-Rocha, Patricia Clark, Simón Barquera, Edgar Denova-Gutiérrez
    Annals of Hepatology.2023; 28(1): 100873.     CrossRef
  • Validation of five hepatic steatosis algorithms in metabolic‐associated fatty liver disease: A population based study
    Yuxiu Liu, Shiying Liu, Jiaofeng Huang, Yueyong Zhu, Su Lin
    Journal of Gastroenterology and Hepatology.2022; 37(5): 938.     CrossRef
  • Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
    Jiwon Kim, Minyoung Lee, Soo Yeon Kim, Ji-Hye Kim, Ji Sun Nam, Sung Wan Chun, Se Eun Park, Kwang Joon Kim, Yong-ho Lee, Joo Young Nam, Eun Seok Kang
    Endocrinology and Metabolism.2021; 36(4): 823.     CrossRef
  • Validation of a Non-Laboratory Based Screening Tool for Predicting Non-Alcoholic Fatty Liver Disease in an Egyptian Setting
    Ekram W. Abd El-Wahab, Rehab A. Zein El-Abedin, Walid M. Ahmed, Hanan Z. Shatat
    The American Journal of the Medical Sciences.2020; 360(6): 662.     CrossRef
  • Validation of simple indexes for nonalcoholic fatty liver disease in western China: a retrospective cross-sectional study
    Jinzhou Zhu, Mingqing He, Yong Zhang, Tingxin Li, Yuping Liu, Zhiye Xu, Weichang Chen
    Endocrine Journal.2018; 65(3): 373.     CrossRef
  • Fatty liver indices in the multiethnic United States National Health and Nutrition Examination Survey
    C. E. Ruhl, J. E. Everhart
    Alimentary Pharmacology & Therapeutics.2015; 41(1): 65.     CrossRef
  • Reducing Liver Fat by Low Carbohydrate Caloric Restriction Targets Hepatic Glucose Production in Non-Diabetic Obese Adults with Non-Alcoholic Fatty Liver Disease
    Haoyong Yu, Weiping Jia, ZengKui Guo
    Journal of Clinical Medicine.2014; 3(3): 1050.     CrossRef
  • Clinical Correlation between Serum Cytokeratin-18 and Metabolic Parameters in Patients with Sonographic Non-alcoholic Fatty Liver Disease
    Dong Shin Kwak, Dae Won Jun, Yong Kyun Cho, Seung Min Lee, Se Hwan Lee, In Sub Jung, Sung Won Lee, Jae Keun Park, JungHoon Lee, Eun Young Lee, Min Rho, Kang Lok Lee, Jun Kwon Ko, Soon-Eung Park
    The Korean Journal of Gastroenterology.2014; 64(4): 206.     CrossRef
  • The Wide and Complex Field of NAFLD Biomarker Research: Trends
    Erika Wichro, Tanja Macheiner, Jasmin Schmid, Barbara Kavsek, Karine Sargsyan
    ISRN Hepatology.2014; 2014: 1.     CrossRef
  • Non–Laboratory-Based Self-Assessment Screening Score for Non-Alcoholic Fatty Liver Disease: Development, Validation and Comparison with Other Scores
    Yong-ho Lee, Heejung Bang, Young Min Park, Ji Cheol Bae, Byung-Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee, Beverley Balkau, Won-Young Lee, Dae Jung Kim, Anna Alisi
    PLoS ONE.2014; 9(9): e107584.     CrossRef
  • Noninvasive predictors of nonalcoholic steatohepatitis in Korean patients with histologically proven nonalcoholic fatty liver disease
    Young Seok Kim, Eun Sun Jung, Wonhee Hur, Si Hyun Bae, Jong Young Choi, Myeong Jun Song, Chang Wook Kim, Se Hyun Jo, Chang Don Lee, Young Sok Lee, Sang Wook Choi, Jin Mo Yang, Jeong Won Jang, Sang Gyune Kim, Seung Won Jung, Hee Kyung Kim, Hee Bok Chae, Se
    Clinical and Molecular Hepatology.2013; 19(2): 120.     CrossRef
  • Diagnosing Fatty Liver Disease: A Comparative Evaluation of Metabolic Markers, Phenotypes, Genotypes and Established Biomarkers
    Sabine Siegert, Zhonghao Yu, Rui Wang-Sattler, Thomas Illig, Jerzy Adamski, Jochen Hampe, Susanna Nikolaus, Stefan Schreiber, Michael Krawczak, Michael Nothnagel, Ute Nöthlings, Erica Villa
    PLoS ONE.2013; 8(10): e76813.     CrossRef
  • 11,726 View
  • 72 Download
  • Crossref