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"Kyoung Min Sohn"

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"Kyoung Min Sohn"

Original Article

Liver fibrosis, cirrhosis, and portal hypertension

Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis: a multicenter retrospective study in Korea
Jin Nyoung Kim, Kyoung Min Sohn, Moon Young Kim, Ki Tae Suk, Soung Won Jeong, Ho Eun Jung, Sae Hwan Lee, Sang Gyune Kim, Jae Young Jang, Young Seok Kim, Soon Koo Baik, Hong Soo Kim, Dong Joon Kim, Boo Sung Kim
Korean J Hepatol 2012;18(4):391-396.
Published online December 21, 2012
DOI: https://doi.org/10.3350/cmh.2012.18.4.391
Background/Aims

Variceal hemorrhage is one of the major complications of cirrhosis and is associated with significant mortality and morbidity. The development of gastroesophageal varices and variceal hemorrhage is the most direct consequence of portal hypertension. Correlations between the hepatic venous pressure gradient (HVPG) and first variceal hemorrhage were examined.

Methods

Patients with cirrhosis who underwent HVPG measurement between July 2009 and September 2010 were enrolled (n=535). All patients underwent esophagogastroduodenoscopy to enable the evaluation of gastroesophageal varices.

Results

The HVPG for all patients was 16.46±7.05 mmHg (mean±SD), and was significantly higher among those with first variceal hemorrhage than in those without it. The HVPG was significantly correlated with both Child-Turcotte-Pugh (r=0.488, P<0.001) and Model for End-stage Liver Disease (r=0.478, P<0.001) scores. An HVPG value of 11 mmHg was predictive of first variceal hemorrhage with a sensitivity of 92.4% and a specificity of 27.7%.

Conclusions

The HVPG was higher in patients with first variceal hemorrhage than in those without it.

Citations

Citations to this article as recorded by  Crossref logo
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    BMC Gastroenterology.2024;[Epub]     CrossRef
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  • Invasive measurement of portal hypertension in the hemodynamics laboratory as an important element of qualification for the treatment of esophageal varices: A single-center experience
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    Polish Annals of Medicine.2021;[Epub]     CrossRef
  • Long-term efficacy of subtotal splenectomy due to portal hypertension in cirrhotic patients
    Haibo Chu, Wei Han, Lei Wang, Yongbo Xu, Fengguo Jian, Weihua Zhang, Tao Wang, Jianhua Zhao
    BMC Surgery.2015;[Epub]     CrossRef
  • Staging of liver fibrosis or cirrhosis: The role of hepatic venous pressure gradient measurement
    Ki Tae Suk
    World Journal of Hepatology.2015; 7(3): 607.     CrossRef
  • Hepatic venous pressure gradient: clinical use in chronic liver disease
    Ki Tae Suk
    Clinical and Molecular Hepatology.2014; 20(1): 6.     CrossRef
  • Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease
    Won Ki Hong, Kwang Yong Shim, Soon Koo Baik, Moon Young Kim, Mee Yon Cho, Yoon Ok Jang, Young Shik Park, Jin Han, Gaeun Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Sang Ok Kwon
    Journal of Korean Medical Science.2014; 29(3): 392.     CrossRef
  • The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data
    Won Ki Hong, Moon Young Kim, Soon Koo Baik, Seung Yong Shin, Jung Min Kim, Yong Seok Kang, Yoo Li Lim, Young Ju Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Hyoun A Kim, Hye Won Kang, Sang Ok Kwon
    Clinical and Molecular Hepatology.2013; 19(4): 370.     CrossRef
  • Characteristics of alcoholic liver disease and predictive factors for mortality of patients with alcoholic cirrhosis
    Yan-Di Xie, Bo Feng, Yan Gao, Lai Wei
    Hepatobiliary & Pancreatic Diseases International.2013; 12(6): 594.     CrossRef
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