Clinical and Molecular Hepatology

"Mong Cho"

Original Article

Liver fibrosis, cirrhosis, and portal hypertension

Emergency endoscopic variceal ligation in cirrhotic patients with blood clots in the stomach but no active bleeding or stigmata increases the risk of rebleeding: Su Jin Kim, Cheol Woong Choi, Dae Hwan Kang, Hyung Wook Kim, Su Bum Park, Young Mi Hong, Ki Tae Yoon, Mong Cho, Hyung Seok Nam, SM Bakhtiar UI Islam; Clin Mol Hepatol 2016;22(4):466-476.
Published online December 25, 2016; DOI: https://doi.org/10.3350/cmh.2016.0063

Abstract
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Background/Aims
This study aimed to evaluate the efficacy and safety of emergency variceal ligation for the prevention of rebleeding in cirrhotic patients who are found on initial endoscopy to have blood clots in the stomach but no actively bleeding esophageal and gastric varices or stigmata.
Methods
This study included 28 cirrhotic patients who underwent emergency prophylactic EVL and 41 who underwent an elective intervention between January 2009 and June 2014. Clinical outcomes were analyzed, including the rebleeding, 6-week mortality, and rebleeding-free survival rates.
Result
s: The rebleeding rate was higher in the emergency than in the elective group (28.6% vs. 7.3%, P=0.041). Multivariate analysis showed that emergency prophylactic EVL (odds ratio [OR] = 7.4, 95% confidence interval [CI]=1.634.8, P=0.012) and Child-Pugh score C (OR=10.6, 95% CI=1.4-80.8, P=0.022) were associated with rebleeding. In the emergency group, the gastric varices were associated with rebleeding (OR=12.0, 95% CI=1.7-83.5, P=0.012).
Conclusions
Emergency EVL may be associated with variceal rebleeding when blood clots are present in the stomach without active esophageal and gastric variceal bleeding or stigmata. Elective intervention should be considered as a safer strategy for preventing variceal rebleeding in this situation.

Citations

Citations to this article as recorded by

Combining endoscopic variceal ligation and omeprazole sodium in treating upper gastrointestinal hemorrhage combined with liver cirrhosis
Changfang Xie, Shilei Gong, Zhenfeng Zhao, Lu Liu, Lu Lu, Jin Zhou, Xiaohuan Yu, Ying Xiong
BMC Gastroenterology.2025;[Epub] CrossRef
Minimal and Maximal Extent of Band Ligation for Acute Variceal Bleeding during the First Endoscopic Session
Jang Han Jung, Jung Hyun Jo, Sung Eun Kim, Chang Seok Bang, Seung In Seo, Chan Hyuk Park, Se Woo Park
Gut and Liver.2022; 16(1): 101. CrossRef
Bedside risk‐scoring model for predicting 6‐week mortality in cirrhotic patients undergoing endoscopic band ligation for acute variceal bleeding
Jung Hee Kim, Se Woo Park, Jang Han Jung, Da Hae Park, Chang Seok Bang, Chan Hyuk Park, Ji Won Park, Jae Gun Park
Journal of Gastroenterology and Hepatology.2021; 36(7): 1935. CrossRef
Clinical outcomes of sedation during emergency endoscopic band ligation for variceal bleeding: Multicenter cohort study
Chan Hyuk Park, Se Woo Park, Jang Han Jung, Gyeong Guk Kim, Se Young Choi, Eun Sun Kim, Dong Hyun In, Hong Deok Kim
Digestive Endoscopy.2020; 32(6): 894. CrossRef
Endoscopic Removal of Inflated Transected Sengstaken–Blakemore Tube Using Endoscopic Scissors
Jun Ho Lee, Eu-Kwon Hwang, Chanmesa Doeun, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim
Clinical Endoscopy.2019; 52(2): 182. CrossRef
Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis
Kyeong-Ah Kwak, Hyun-Jae Cho, Jin-Young Yang, Young-Seok Park
Canadian Journal of Gastroenterology and Hepatology.2018; 2018: 1. CrossRef

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6 Web of Science
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Case Report

Hepatic neoplasm

Bone marrow metastasis presenting as bicytopenia originating from hepatocellular carcinoma: Young Mi Hong, Ki Tae Yoon, Mong Cho, Dae Hwan Kang, Hyung Wook Kim, Cheol Woong Choi, Su Bum Park, Jeong Heo, Hyun Young Woo, Won Lim, SM Bakhtiar UI Islam; Clin Mol Hepatol 2016;22(2):267-271.
Published online May 16, 2016; DOI: https://doi.org/10.3350/cmh.2015.0017

Abstract
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The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargement that was detected when examining his general weakness and weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated liver enzymes, normal prothrombin time percentage and high levels of tumor markers (α-fetoprotein and des-γ-carboxyprothrombin). Abdominal computed tomography showed multiple enhanced masses in the liver and multiple enlarged lymph nodes in the abdomen. A bone marrow biopsy revealed only a few normal hematopoietic cells and abundant tumor cells. Despite its rarity, bone marrow metastasis should always be suspected in HCC patients even if accompanied by cirrhosis.

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Clinical features and treatment of bone marrow metastasis
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Oncology Letters.2023;[Epub] CrossRef
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Naomi Matsutani, Yuichiro Yokoyama, Shogo Shiratsuki, Shinya Kuwashiro, Kosuke Okita, Taro Takami, Isao Sakaida
Kanzo.2022; 63(1): 16. CrossRef
Rare Site Hepatocellular Carcinoma Metastasis

Enrique Boldo, Ana Santafe, Araceli Mayol, Rafael Lozoya, Alba Coret, Diana Escribano, Carlos Fortea, Andres Muñoz, Juan Carlos Pastor, Guillermo Pérez de Lucia, Nuria Bosch Aparicio
Journal of Hepatocellular Carcinoma.2020; Volume 7: 39. CrossRef
Presumed disseminated carcinomatosis of the bone marrow in a dog
Bárbara Andreia Jardim Gomes, Eilidh Gunn, Caroline Millins, Elspeth M Waugh, Gawain Hammond
Veterinary Record Case Reports.2020;[Epub] CrossRef
Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4
Zhongrong Guo, Wen Chen, Guisen Dai, Yuanliang Huang
International Journal of Molecular Medicine.2019;[Epub] CrossRef
Malignant Pleural Mesothelioma with Bone Marrow Metastases
Hiroaki Ihara, Norihiro Harada, Naoko Shimada, Koichiro Kanamori, Takuo Hayashi, Toshimasa Uekusa, Kazuhisa Takahashi
Internal Medicine.2018; 57(17): 2541. CrossRef

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8 Web of Science
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Letter to the Editor

Hepatic neoplasm

A case of small hepatocellular carcinoma with an extensive lymph node metastasis at diagnosis: Young Mi Hong, Ki Tae Yoon, Mong Cho, Jeong Heo, Hyun Young Woo, Won Lim; Clin Mol Hepatol 2014;20(3):310-312.
Published online September 26, 2014; DOI: https://doi.org/10.3350/cmh.2014.20.3.310

Citations

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A rare case of infiltrative hepatocellular carcinoma presented with neck mass
Yu‐Kwang Lee, Chung‐Chieh Wang, Yu‐Tse Chiu, Tai‐Chung Tseng
Advances in Digestive Medicine.2021; 8(1): 51. CrossRef
Screening, clinical features and prognostic analysis of liver cirrhosis-related hepatocellular carcinoma
Zhengwei Zha, Wenyue Wu, Qianqian Zhang, Xi Wang, Xuecan Mei, Yi Xiang, Derun Kong
Scandinavian Journal of Gastroenterology.2021; 56(8): 948. CrossRef
LINC01287 regulates tumorigenesis and invasion via miR‐298/MYB in hepatocellular carcinoma
Yichao Mo, Longguang He, Zeru Lai, Zhiheng Wan, Qinshou Chen, Sibo Pan, Liangfu Li, Dasheng Li, Junwei Huang, Fan Xue, Siyao Che
Journal of Cellular and Molecular Medicine.2018; 22(11): 5477. CrossRef
Application of contrast‑enhanced ultrasound and enhanced CT in diagnosis of liver cancer and evaluation of radiofrequency ablation
Shuhong Kong, Xuewang Yue, Sheng Kong, Yujie Ren
Oncology Letters.2018;[Epub] CrossRef
Study on the diagnosis of small hepatocellular carcinoma caused by hepatitis B cirrhosis via multi‑slice spiral CT and MRI
Mei Wang, Congxin Wei, Zhaojuan Shi, Jianzhong Zhu
Oncology Letters.2017;[Epub] CrossRef

9,455 View
63 Download
6 Web of Science
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Original Articles

Rescue therapy with adefovir in decompensated liver cirrhosis patients with lamivudine-resistant hepatitis B virus: Hyun Young Woo, Jong Young Choi, Seung Kew Yoon, Dong Jin Suh, Seung Woon Paik, Kwang Hyub Han, Soon Ho Um, Byung Ik Kim, Heon Ju Lee, Mong Cho, Chun Kyon Lee, Dong Joon Kim, Jae Seok Hwang; Clin Mol Hepatol 2014;20(2):168-176.
Published online June 30, 2014; DOI: https://doi.org/10.3350/cmh.2014.20.2.168

Abstract
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Background/Aims

Adefovir dipivoxil (ADV) is a nucleotide analogue that is effective against lamivudine-resistant hepatitis B virus (HBV). The aim of this study was to determine the long-term clinical outcomes after ADV rescue therapy in decompensated patients infected with lamivudine-resistant HBV.

Methods

In total, 128 patients with a decompensated state and lamivudine-resistant HBV were treated with ADV at a dosage of 10 mg/day for a median of 33 months in this multicenter cohort study.

Results

Following ADV treatment, 86 (72.3%) of 119 patients experienced a decrease in Child-Pugh score of at least 2 points, and the overall end-stage liver disease score decreased from 16±5 to 14±10 (mean ± SD, P<0.001) during the follow-up period. With ADV treatment, 67 patients (56.3%) had undetectable serum HBV DNA (detection limit, 0.5 pg/mL). Virologic breakthrough occurred in 38 patients (36.1%) and 9 patients had a suboptimal ADV response. The overall survival rate was 89.9% (107/119), and a suboptimal response to ADV treatment was associated with both no improvement in Child-Pugh score (≥2 points; P=0.001) and high mortality following ADV rescue therapy (P=0.012).

Conclusions

Three years of ADV treatment was effective and safe in decompensated patients with lamivudine-resistant HBV.

Citations

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Targeting hepatitis B virus-associated nephropathy: efficacy and challenges of current antiviral treatments
Yongzheng Hu, Yue Zhang, Wei Jiang
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Autologous bone marrow cell transplantation in the treatment of HIV patients with compensated cirrhosis
Baochi Liu, Mingrong Cheng, Xiaodong Chen, Lei Li, Yanhui Si, Shijia Wang, Ying Wang, Yufang Shi
Bioscience Reports.2020;[Epub] CrossRef
Analysis of the prevalence of drug-resistant hepatitis B virus in patients with antiviral therapy failure in a Chinese tertiary referral liver centre (2010–2014)
Tian Meng, Xiaofeng Shi, Xuyang Gong, Haijun Deng, Yao Huang, Xuefeng Shan, Youlan Shan, Ailong Huang, Quanxin Long
Journal of Global Antimicrobial Resistance.2017; 8: 74. CrossRef

11,870 View
65 Download
5 Web of Science
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Effect of aldosterone on the amplification of oncolytic vaccinia virus in human cancer lines: Hyun Ju Lee, Jasung Rho, Shao Ran Gui, Mi Kyung Kim, Yu Kyoung Lee, Yeon Sook Lee, Jeong Eun Kim, Euna Cho, Mong Cho, Tae-Ho Hwang; Korean J Hepatol 2011;17(3):213-219.
Published online September 30, 2011; DOI: https://doi.org/10.3350/kjhep.2011.17.3.213

Abstract
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Background/Aims

JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma patients having high levels of aldosterone and virus amplification in JX-594 treatment, we investigated the association between virus amplification and aldosterone in human cancer cell lines.

Methods

Cell proliferation was determined by a cell-counting-kit-based colorimetric assay, and vaccinia virus quantitation was performed by quantitative polymerase chain reaction (qPCR) and a viral plaque assay. Also, the intracellular pH was measured using a pH-sensitive dye.

Results

Simultaneous treatment with JX-594 and aldosterone significantly increased viral replication in A2780, PC-3, and HepG2 cell lines, but not in U2OS cell lines. Furthermore, the aldosterone treatment time altered the JX-594 replication according to the cell line. The JX-594 replication peaked after 48 and 24 hours of treatment in PC-3 and HepG2 cells, respectively. qPCR showed that JX-594 entry across the plasma membrane was increased, however, the changes are not significant by the treatment. This was inhibited by treatment with spironolactone (an aldosterone-receptor inhibitor). JX-594 entry was significantly decreased by treatment with EIPA [5-(N-ethyl-N-isopropyl)amiloride; a Na⁺/H⁺-exchange inhibitor], but aldosterone significantly restored JX-594 entry even in the presence of EIPA. Intracellular alkalization was observed after aldosterone treatment but was acidified by EIPA treatment.

Conclusions

Aldosterone stimulates JX-594 amplification via increased virus entry by affecting the H⁺ gradient.

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Research progress and development potential of oncolytic vaccinia virus
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European Heart Journal.2024; 45(14): 1224. CrossRef
Recent progress in combination therapy of oncolytic vaccinia virus
Seyedeh Nasim Mirbahari, Miles Da Silva, Abril Ixchel Muñoz Zúñiga, Nika Kooshki Zamani, Gabriel St-Laurent, Mehdi Totonchi, Taha Azad
Frontiers in Immunology.2024;[Epub] CrossRef