Clinical and Molecular Hepatology

"So-Young Jin"

Original Article

Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma: Soon Ha Kwon, Soung Won Jeong, Jae Young Jang, Ji Eun Lee, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, So-Young Jin; Korean J Hepatol 2012;18(3):287-294.
Published online September 25, 2012; DOI: https://doi.org/10.3350/cmh.2012.18.3.287

Abstract
PDF

Background/Aims

Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and HCC.

Methods

The immunohistochemical expressions of COX-2 and VEGF were evaluated in tissues from patients with CH (n=95), cirrhosis (n=38), low-grade HCC (LG-HCC; n=6), and high-grade HCC (HG-HCC; n=29).

Results

The COX-2 expression scores in CH, cirrhosis, LG-HCC, and HG-HCC were 3.3±1.9 (mean±SD), 4.2±1.7, 5.5±1.0, and 3.4±2.4, respectively (CH vs. cirrhosis, P=0.016; CH vs. LG-HCC, P=0.008; LG-HCC vs. HG-HCC, P=0.004), and the corresponding VEGF expression scores were 0.9±0.8, 1.5±0.7, 1.8±0.9, and 1.6±1.1 (CH vs. cirrhosis, P<0.001; CH vs. LG-HCC, P=0.011; LG-HCC vs. HG-HCC, P=0.075). Both factors were correlated with the fibrosis stage in CH and cirrhosis (COX-2: r=0.427, P<0.001; VEGF: r=0.491, P<0.001). There was a significant correlation between COX-2 and VEGF in all of the tissue samples (r=0.648, P<0.001), and between high COX-2 and VEGF expression scores and survival (COX-2: P=0.001; VEGF: P<0.001).

Conclusions

The expressions of both COX-2 and VEGF are significantly higher in cirrhosis and LG-HCC than in CH. High COX-2 and high VEGF expressions are associated with a high survival rate.

Citations

Citations to this article as recorded by

Correlation and efficacy of TACE combined with lenvatinib plus PD‐1 inhibitor in the treatment of hepatocellular carcinoma with portal vein tumor thrombus based on immunological features
Xinhua Zou, Qingyu Xu, Ran You, Guowen Yin
Cancer Medicine.2023; 12(10): 11315. CrossRef
Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma
Hui Li
Digestive and Liver Disease.2022; 54(5): 598. CrossRef
Altered expression of COX-2 and TNF-a in patients with hepatocellular carcinoma
Andressa de-Freitas-Alves, Vanessa Dido-Baldissera, Eduardo Cremonese-Filippi-Chiela, Carlos Thadeu Schmidt-Cerski, Paulo Roberto Ott-Fontes, Marilda da-Cruz-Fernandes, Marilene Porawski, Márcia Giovenardi
Revista Española de Enfermedades Digestivas.2019;[Epub] CrossRef
HBx combined with AFB1 triggers hepatic steatosis via COX‐2‐mediated necrosome formation and mitochondrial dynamics disorder
Yuan‐Yuan Chen, Yi Lin, Pei‐Yu Han, Shan Jiang, Lin Che, Cheng‐Yong He, Yu‐Chun Lin, Zhong‐Ning Lin
Journal of Cellular and Molecular Medicine.2019; 23(9): 5920. CrossRef
Fluorescence imaging of hepatocellular carcinoma with a specific probe of COX-2
Haibo Wang, Chengyong Dong, Keqiu Jiang, Shuangzhe Zhang, Fei Long, Rixin Zhang, Deguang Sun, Rui Liang, Zhenming Gao, Shujuan Shao, Liming Wang
RSC Advances.2018; 8(2): 994. CrossRef
Hepatic sinusoids in liver injury, inflammation, and fibrosis: new pathophysiological insights
Thomas Greuter, Vijay H. Shah
Journal of Gastroenterology.2016; 51(6): 511. CrossRef
Immunohistochemical angiogenic biomarkers in hepatocellular carcinoma and cirrhosis: correlation with pathological features
Osmar Damasceno Ribeiro, Nathalie Henriques Silva Canedo, Vera Lucia Pannain
Clinics.2016; 71(11): 639. CrossRef
Liver sinusoidal endothelial cells in hepatic fibrosis
Laurie D. DeLeve
Hepatology.2015; 61(5): 1740. CrossRef
Constitutive activation of AMPK α1 in vascular endothelium promotes high‐fat diet‐induced fatty liver injury: role of COX‐2 induction
Yan Liang, Bosheng Huang, Erfei Song, Bo Bai, Yu Wang
British Journal of Pharmacology.2014; 171(2): 498. CrossRef
Glycyrrhetinic Acid Suppressed NF-κB Activation in TNF-α-Induced Hepatocytes
Hong-Jhang Chen, Shih-Pei Kang, I-Jung Lee, Yun-Lian Lin
Journal of Agricultural and Food Chemistry.2014; 62(3): 618. CrossRef
Meloxicam Executes Its Antitumor Effects against Hepatocellular Carcinoma in COX-2- Dependent and -Independent Pathways
Xiaofeng Dong, Rui Li, Peng Xiu, Xuesong Dong, Zongzhen Xu, Bo Zhai, Feng Liu, Hongchi Jiang, Xueying Sun, Jie Li, Haiquan Qiao, Diego Calvisi
PLoS ONE.2014; 9(3): e92864. CrossRef
Epithelial VEGF signaling is required in the mouse liver for proper sinusoid endothelial cell identity and hepatocyte zonation in vivo
Teagan J. Walter, Ashley E. Cast, Kari A. Huppert, Stacey S. Huppert
American Journal of Physiology-Gastrointestinal and Liver Physiology.2014; 306(10): G849. CrossRef

11,213 View
92 Download
Crossref

Liver Pathologys

Early hepatocellular carcinoma: So-Young Jin, In Ho Choi; Korean J Hepatol 2011;17(3):238-241.
Published online September 30, 2011; DOI: https://doi.org/10.3350/kjhep.2011.17.3.238

Citations

Citations to this article as recorded by

The glycolysis-lactylation axis: a metabolic-epigenetic driver of immunosuppression and therapy resistance in cancer
Simin Tan, Weijia Zhang, Yuqing Ding, Jinlin Liu, Min Zhu, Xuefeng Luo, Jun Cai, Hai Zeng
Frontiers in Immunology.2026;[Epub] CrossRef
Expansile invasive growth pattern is definite evidence for the diagnosis of small hepatocellular carcinomas: a comparative study of 37 cases
Qiongrong Chen, Manxiang Wang, Mingwei Wang, Su Jin, Shu-yuan Xiao, Sufang Tian
Human Pathology.2018; 80: 130. CrossRef

8,619 View
42 Download
Crossref

Cholangiocarcinoma arising in von Meyenburg complexes: Hee Kyung Kim, So-Young Jin; Korean J Hepatol 2011;17(2):161-164.
Published online June 23, 2011; DOI: https://doi.org/10.3350/kjhep.2011.17.2.161

Citations

Citations to this article as recorded by

Cystic Hepatic Lesions: A Concise Review of Literature
Anu Abraham, Varsha Prakash, Akhila Aravind, Neha Varshney
International Journal of Surgical Pathology.2026;[Epub] CrossRef
Intrahepatic cholangiocarcinoma developing from biliary hamartomas: A case report and literature review
Olfa Ghannei, Soumaya Ben Amor, Mayada Trimech
International Journal of Surgery Case Reports.2025;[Epub] CrossRef
Ductal Plate Malformation Revisited: biliary lesions from polycystic hepatorenal disease. An educational review.
Manuel Romero-Martínez, Alberto Gómez Gómez, Marcos Sánchez Martínez, José A. Pons, Juan Egea Valenzuela, Fernando Alberca
Revista Española de Enfermedades Digestivas.2025;[Epub] CrossRef
A rare encounter - Unveiling the mysteries of biliary hamartoma: A case report
Deepika C.A., Poornachandra Thejeswi, Shivananda Prabhu, Jyothi Kini
International Journal of Surgery Case Reports.2024;[Epub] CrossRef
Von Meyenburg complexes mimicking liver metastases of cholangiocarcinoma
Marta Urzay Gutiérrez, María Victoria Vieiro Medina, Santos Jiménez de los Galanes Marchán
Journal of Gastrointestinal Surgery.2024; 28(2): 191. CrossRef
Multiple biliary microhamartomas diagnosed in an unsuspecting elderly patient
Marina Balbino, Manuela Montatore, Giacomo Fascia, Ruggiero Tupputi, Federica Masino, Gianmichele Muscatella, Domenico Mannatrizio, Giuseppe Guglielmi
Digital Diagnostics.2024; 5(2): 334. CrossRef
Management of intrahepatic and perihilar cholangiocarcinomas: Guidelines of the French Association for the Study of the Liver (AFEF)
Cindy Neuzillet, Marie Decraecker, Hélène Larrue, Line C. Ntanda‐Nwandji, Louise Barbier, Sandrine Barge, Arthur Belle, Carine Chagneau, Julien Edeline, Catherine Guettier, Florence Huguet, Jérémie Jacques, Brigitte Le Bail, Sarah Leblanc, Maïté Lewin, Da
Liver International.2024; 44(10): 2517. CrossRef
Multiple biliary duct hamartomas in a cat resulting in a hepatic mass: A case report
Rachel Naghi, Judith Bertran, Elisa Spoldi, Michael J. Dark, Helena Hauck de Oliveira, Carlos Souza, Elizabeth A. Maxwell
Veterinary Medicine and Science.2023; 9(4): 1441. CrossRef
A CASE REPORT OF VON MEYENBURG COMPLEXES
V. Hadzhiminev, A. Sarpanov, G. E. Markov, K. Kalacheva, B. Atanasov, V. Belovezhdov V. Belovezhdov
Trakia Journal of Sciences.2023; 21(1): 69. CrossRef
INTRAHEPATIC BILIARY PROLIFERATIONS: HISTOPATHOLOGY AND POTENTIAL IMMUNOHISTOCHEMICAL MARKERS
André Bubna HIRAYAMA, Evandro Sobroza de MELLO, Venâncio Avancini Ferreira ALVES
Arquivos de Gastroenterologia.2023; 60(3): 393. CrossRef
Intrahepatic Cholangiocarcinoma Arising from Biliary Hamartomas in Patients with Recurrent Acute Cholangitis: A Case Report and Literature Review
Sang Min Lee, Ki Bae Kim, Joung-Ho Han, Chang Gok Woo, Hee Bok Chae, Seon Mee Park
The Korean Journal of Gastroenterology.2023; 82(3): 145. CrossRef
Biliary Duct Hamartomas: A Systematic Review
Abdul Ahad E Sheikh, Anthony P Nguyen, Katarina Leyba, Nismat Javed, Sana Shah, Alexander Deradke, Christopher Cormier, Rahul Shekhar, Abu Baker Sheikh
Cureus.2022;[Epub] CrossRef
A Case of Multicystic Biliary Hamartoma Treated with Left Medial Sectionectomy
Naomi KUROKI, Tomoaki TANAKA, Takanobu SUGASE, Syoji TANIGUCHI, Takashi GOTO, Rintaro KOGA, Takumi KIWAKI, Hiroyuki TANAKA
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2022; 83(2): 395. CrossRef
Zystische Leberläsionen – Diagnostik und Therapieoptionen
Jonas Babel, Sebastian Rademacher, Timm Denecke, Daniel Seehofer
Allgemein- und Viszeralchirurgie up2date.2021; 15(05): 407. CrossRef
Ductal Plate Malformations in Captive Snakes
Olivia M. Patania, Brigid V. Troan, John M. Cullen
Veterinary Pathology.2021; 58(4): 736. CrossRef
A Case Report of Cholangiocarcinoma Arising from a Biliary Adenofibroma: Radiologic Findings and Review of Literature
Hyun-Ji Lim, Mi-Suk Park, Young Nyun Park, Sun Il Kim, Yeo-Eun Kim, Cheong Hoon Hwang
Journal of the Korean Society of Radiology.2021; 82(3): 721. CrossRef
Von Meyenburg Complexes Mimicking Diffuse Metastatic Liver Disease
Nikolaos S. Salemis, Ilias Katikaridis, Andreas Zografidis
Journal of Gastrointestinal Cancer.2019; 50(4): 972. CrossRef
Bile Duct Hamartoma Mimicking Metastatic Cholangiocarcinoma
Raymond Elsoueidi, Stephen J. Mularz, Elie M. Richa
Journal of Gastrointestinal Cancer.2017; 48(1): 87. CrossRef
Multicystic biliary hamartoma with extremely elevated CA19-9: a case report
Takeshi Morinaga, Katsunori Imai, Yo-Ichi Yamashita, Takanobu Yamao, Takayoshi Kaida, Shigeki Nakagawa, Daisuke Hashimoto, Akira Chikamoto, Shinji Sumiyoshi, Yoshiki Mikami, Hideo Baba
Scandinavian Journal of Gastroenterology.2017; 52(8): 916. CrossRef
Cystic lesions of the liver—A review
Maheswaran Pitchaimuthu, Mark Duxbury
Current Problems in Surgery.2017; 54(10): 514. CrossRef
Surgery is the preferred treatment for bile duct hamartomas
Xiao-Yu Yang, Hai-Bo Zhang, Bin Wu, Ai-Jun Li, Xiao-Hui Fu
Molecular and Clinical Oncology.2017; 7(4): 649. CrossRef
Imaging of Von Meyenburg complexes
L. Pech, S. Favelier, M.T. Falcoz, R. Loffroy, D. Krause, J.P. Cercueil
Diagnostic and Interventional Imaging.2016; 97(4): 401. CrossRef
Child's von meyenburg complexes
Anna Makhneva, Bekisheva Aigul, Bulegenova Minira, Adamova Gauhar
Journal of Histology and Histopathology.2015; 2(1): 15. CrossRef
Malignant Transformation in Von-Meyenburg Complexes
Vishwas Parekh, Deniz Peker
Applied Immunohistochemistry & Molecular Morphology.2015; 23(9): 607. CrossRef
Biliary hamartoma presented as a single mass
Yong Moon Shin
The Korean Journal of Hepatology.2011; 17(4): 331. CrossRef

9,299 View
66 Download
Crossref

Sclerosed hemangioma of the liver: So-Young Jin; Korean J Hepatol 2010;16(4):410-413.
Published online December 31, 2010; DOI: https://doi.org/10.3350/kjhep.2010.16.4.410

Citations

Citations to this article as recorded by

Added Value of Ultrasound-Based Multimodal Imaging to Diagnose Hepatic Sclerosed Hemangioma before Biopsy and Resection
Feiqian Wang, Kazushi Numata, Hiromi Nihonmatsu, Makoto Chuma, Naomi Ideno, Akito Nozaki, Katsuaki Ogushi, Mikiko Tanab, Masahiro Okada, Wen Luo, Masayuki Nakano, Masako Otani, Yoshiaki Inayama, Shin Maeda
Diagnostics.2022; 12(11): 2818. CrossRef
Case report: Sclerosed hemangioma of the liver: A diagnostic challenge
M. Poras, G. Katsanos, A. C. Agrafiotis, P. Demetter, M. Pezzullo, V. Lucidi
Frontiers in Surgery.2022;[Epub] CrossRef
Hepatic sclerosed hemangioma and sclerosing cavernous hemangioma: a radiological study
Cuiyu Jia, Guangxue Liu, Xinxin Wang, Dawei Zhao, Ruili Li, Hongjun Li
Japanese Journal of Radiology.2021; 39(11): 1059. CrossRef
Preoperative diagnosis of the sclerosed hemangioma of the liver using multimodality imaging findings: A case report
Kumi Ozaki, Jun Yoshikawa, Toru Yamamoto, Kazuya Maeda, Yasuharu Kaizaki
Radiology Case Reports.2018; 13(5): 1025. CrossRef
Hepatic Sclerosing Hemangioma with Predominance of the Sclerosed Area Mimicking a Biliary Cystadenocarcinoma
Hiroyuki Sugo, Yuki Sekine, Shozo Miyano, Ikuo Watanobe, Michio Machida, Kuniaki Kojima, Hironao Okubo, Ayako Ura, Kanako Ogura, Toshiharu Matsumoto
Case Reports in Hepatology.2018; 2018: 1. CrossRef
Multiple hepatic sclerosing hemangioma mimicking metastatic liver tumor successfully treated by laparoscopic surgery
Masaki Wakasugi, Shigeyuki Ueshima, Mitsuyoshi Tei, Masayuki Tori, Ken-ichi Yoshida, Masahiko Tsujimoto, Hiroki Akamatsu
International Journal of Surgery Case Reports.2015; 8(C): 137. CrossRef
Sclerosed Hemangioma Accompanied by Multiple Cavernous Hemangiomas of the Liver
Airo Tsubura
American Journal of Case Reports.2015; 16: 401. CrossRef
Hepatic Sclerosed Hemangioma: a case report and review of the literature
Shunsuke Miyamoto, Akihiko Oshita, Yutaka Daimaru, Masaru Sasaki, Hideki Ohdan, Atsushi Nakamitsu
BMC Surgery.2015;[Epub] CrossRef
Sclerosed hemangioma of the liver: Concordance of MRI features with histologic characteristics
Carole A. Ridge, Jinru Shia, Scott R. Gerst, Richard K.G. Do
Journal of Magnetic Resonance Imaging.2014; 39(4): 812. CrossRef
Sclerosing hemangioma in the liver
Yong Moon Shin
The Korean Journal of Hepatology.2011; 17(3): 242. CrossRef