Clinical and Molecular Hepatology

"Woo Sun Rou"

Original Articles

Liver fibrosis, cirrhosis, and portal hypertension

Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study: Suk-Yong Jang, Woo Sun Rou, Seok Hyun Kim, Byung Seok Lee, Hyuk Soo Eun; Clin Mol Hepatol 2021;27(2):283-294.
Published online December 3, 2020; DOI: https://doi.org/10.3350/cmh.2020.0227

Abstract
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Background/Aims
Current evidence suggests that liver cirrhosis (LC) causes severe psychological stress and depression, which are risk factors for suicide. Although previous studies reported the association between LC and suicidal thoughts, little is known of its effect on suicidal deaths. Therefore, this study was undertaken to investigate the effect of new-onset LC on suicide.
Methods
From the National Health Insurance Service-National Sample Cohort of South Korea, 5,809 incident LC patients and 11,618 risk-set controls matched by propensity score were selected for follow-up. The incidence rate of suicide was estimated using a generalized estimating equation with a Poisson distribution. Effect size was presented as a hazard ratio (HR) using Cox’s proportional hazards model.
Results
The incidence rate of suicide was 143.3 cases per 100,000 person years (95% confidence interval [CI], 100.2–205.1) among the LC cohort. The LC patients were 2.37 times more likely to commit suicide compared with matched controls (HR, 2.37; 95% CI, 1.44–3.88). Increased suicide risk was evident within the first 2 years of the follow-up period (HR, 2.59; 95% CI, 1.20–5.60) and among the 18–49-year-old age group (HR, 3.72; 95% CI, 1.45–9.56).
Conclusions
Our study found increased risk of suicide in patients with new onset LC, especially during the early period following diagnosis and in younger patients. To decrease this suicide risk, a regular and continuous social support system is required.

Citations

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Sang Yi Moon, Yang Hyun Baek, Dongwoo Kang, Jungkuk Lee, Yeo Wool Kang, Minkook Son, Hongqun Liu, Samuel S. Lee, Junho Park
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Association Between Triglyceride/High-Density Lipoprotein Ratio and Incidence Risk of Heart Failure: A Population-Based Cohort Study
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Comparative Interrupted Time Series Analysis of Direct Medical Expense and Length of Stay in Elderly Patients with Femoral Neck Fractures Who Underwent Total Hip Arthroplasty and Hemiarthroplasty: A Real World Nationwide Database Study
Seung-Hoon Kim, Suk-Yong Jang, Yonghan Cha, Bo-Yeon Kim, Hyo-Jung Lee, Gui-Ok Kim
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Hip & Pelvis.2024; 36(2): 144. CrossRef
Impact of long-term care insurance on medical costs and utilization by patients with Parkinson's disease
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Social Science & Medicine.2023; 317: 115563. CrossRef
Risk of injuries before and after a diagnosis of cirrhosis: A population-based cohort study
Ying Shang, Qing Shen, Elliot B. Tapper, Axel Wester, Hannes Hagström
Hepatology Communications.2023;[Epub] CrossRef
Development of Open-Angle Glaucoma in Adults With Seropositive Rheumatoid Arthritis in Korea
Seung Hoon Kim, Sung Hoon Jeong, Hyunkyu Kim, Eun-Cheol Park, Suk-Yong Jang
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Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study
Sung Hoon Jeong, Seung Hoon Kim, Doo Woong Lee, Eun-Cheol Park, Suk-Yong Jang
BMC Psychiatry.2022;[Epub] CrossRef
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Viral hepatitis

Erectile dysfunction in patients with liver disease related to chronic hepatitis B: Min Kim, Seul Young Kim, Woo Sun Rou, Se Woong Hwang, Byung Seok Lee; Clin Mol Hepatol 2015;21(4):352-357.
Published online December 24, 2015; DOI: https://doi.org/10.3350/cmh.2015.21.4.352

Abstract
PDF

Background/Aims

Despite sexual function making an important contribution to the quality of life, data on erectile function are relatively scant in patients with chronic liver disease. We evaluated the prevalence of and risk factors for erectile dysfunction (ED) in patients with liver disease related to hepatitis B, especially among those with chronic hepatitis B (CHB) or early-stage cirrhosis.

Methods

In total, 69 patients (35 with CHB and 34 with hepatitis-B-related liver cirrhosis [HBV-LC]) aged 40-59 years were analyzed. Child-Pugh classes of A and B were present in 30 (88.2%) and 4 (11.8%) of the patients with HBV-LC, respectively. The erectile function of the patients was evaluated using the Korean version of IIEF-5.

Results

The prevalence of any ED was 24.6% for all patients, and 8.6% and 41.2% for those with CHB and HBV-LC, respectively (P=0.002). While there was only one (2.9%) CHB patient for each stage of ED, mild, moderate, and severe ED stages were seen in three (8.8%), one (2.9%), and ten (29.4%) of the HBV-LC patients, respectively. Multiple regression analysis identified the type of liver disease (P=0.010), hypertension (P=0.022), score on the Beck Depression Inventory (P =0.044), and the serum albumin level (P=0.014) as significant independent factors for the presence of ED.

Conclusions

The prevalence of ED was significantly higher in patients with early-stage HBV-LC than in those with CHB. Therefore, screening male patients with early viral cirrhosis for ED and providing appropriate support are needed, especially when the cirrhosis is accompanied by hypertension, depression, or a depressed level of serum albumin.

Citations

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Editorial

Viral hepatitis

Hepatitis C virus infection in patients with hemophilia in Korea: Is antiviral therapy effective and safe?: Woo Sun Rou, Byung Seok Lee; Clin Mol Hepatol 2015;21(2):122-124.
Published online June 26, 2015; DOI: https://doi.org/10.3350/cmh.2015.21.2.122

Citations

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