Won Sohn, Young-Sun Lee, Soon Sun Kim, Jung Hee Kim, Young-Joo Jin, Gi-Ae Kim, Pil Soo Sung, Jeong-Ju Yoo, Young Chang, Eun Joo Lee, Hye Won Lee, Miyoung Choi, Su Jong Yu, Young Kul Jung, Byoung Kuk Jang, on behalf of The Korean Association for the Study of the Liver (KASL)
Clin Mol Hepatol 2025;31(Suppl):S1-S31. Published online February 19, 2025
Differential Infiltration of T-Cell Populations in Tumor and Liver Tissues Predicts Recurrence-Free Survival in Surgically Resected Hepatocellular Carcinoma Eun Ji Jang, Ho Joong Choi, Young Kyoung You, Deok Hwa Seo, Mi Hyun Kwon, Keungmo Yang, Jaejun Lee, Jeong Won Jang, Seung Kew Yoon, Ji Won Han, Pil Soo Sung Cancers.2025; 17(9): 1548. CrossRef
Metabolic Dysfunction-Associated Steatotic Liver Disease, Recent Revision of Terminology and Its Implications Hyo Young Lee, Eileen L. Yoon The Korean Journal of Gastroenterology.2025; 85(2): 126. CrossRef
Advances in identifying risk factors of metabolic dysfunction-associated alcohol-related liver disease Rui-Qi Ye, Yi-Fan Chen, Chang Ma, Xi Cheng, Wei Guo, Sha Li Biomedicine & Pharmacotherapy.2025; 188: 118191. CrossRef
A Case Report of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) with Improved Cardiometabolic Risk Factors Following Treatment with Saenggangunbi-tang Eun Kyung Lee, Min Jeong Park, Youngchul Kim, Jang-Hoon Lee The Journal of Internal Korean Medicine.2025; 46(2): 303. CrossRef
Food Nutrients and Bioactive Compounds for Managing Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review Erdenetsogt Dungubat, Kohei Fujikura, Masahiko Kuroda, Toshio Fukusato, Yoshihisa Takahashi Nutrients.2025; 17(13): 2211. CrossRef
Associations between steatotic liver disease subtypes and incident atrial fibrillation in young adults: a nationwide cohort study Jeayeon Park, Goh Eun Chung, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho Cardiovascular Diabetology.2025;[Epub] CrossRef
Second-line antidiabetic drugs: friend or foe of the liver Jiwon Yang, Gunho Kim, Ju Hyun Shim, Jihyun An Journal of Liver Cancer.2025; 25(2): 187. CrossRef
Extrahepatic manifestation of metabolic dysfunction-associated steatotic liver disease Anoushka Shenoy, Aijaz Ahmed, Donghee Kim Metabolism and Target Organ Damage.2025;[Epub] CrossRef
2025 Clinical Practice Guidelines for Diabetes: Management of Metabolic Dysfunction-Associated Steatotic Liver Disease Jaehyun Bae The Journal of Korean Diabetes.2025; 26(3): 172. CrossRef
Paired snRNA-seq and scRNA-seq analysis of MASLD patients to identify early-stage markers for disease progression Suebin Park, Su-Hyeon Lee, Se-eun Han, Beom Kyung Kim, Byungjin Hwang Hepatology Communications.2025;[Epub] CrossRef
Sex Hormones and Metabolic Dysfunction-Associated Steatotic Liver Disease Ralf Weiskirchen, Amedeo Lonardo International Journal of Molecular Sciences.2025; 26(19): 9594. CrossRef
Discovery of ultrasound-derived fat fraction as a non-invasive tool for MASLD diagnosis Huiru Jin, Mengfan Jiao, Chengxiao Yu, Tingting Ren, Qingling Chen, Zixing Dai, Erfu Xie, Longfeng Jiang, Yuwen Li European Journal of Medical Research.2025;[Epub] CrossRef
Risk of Esophageal and Gastric Cancer by Histologic Subtype in Steatotic Liver Disease: A UK Biobank Study Donghoon Kang, Ji Won Han, Kenneth R. Muir, Artitaya Lophatananon, Jongin Lee Cancers.2025; 17(21): 3416. CrossRef
Background/Aims Sarcopenia negatively affects the prognosis of cirrhotic patients, but clinical implications of changes in muscle mass remain unclear. We aimed to elucidate its role in the prognosis of outpatients with cirrhosis.
Methods Patients with cirrhosis who underwent annual abdominal computed tomography (CT) for hepatocellular carcinoma surveillance were included in the prospective cohort. The L3 skeletal muscle index (SMI) was adopted as a proxy for the amount of skeletal muscle, and the rate of SMI change between inclusion and after 1 year (ΔSMI/yr%) was calculated.
Results In total, 595 patients underwent a second CT after 1 year. Among them, 109 and 64 patients had sarcopenia and Child-Pugh class B/C decompensation at inclusion, which changed to 103 and 45 at the 1-year follow-up, respectively. During a median follow-up of 30.1 months after 1 year, 86 patients had at least one cirrhosis complication, and 18 died or received liver transplantation. In the development of cirrhosis complications, ΔSMI/yr% was independently associated, even after adjusting for the Child-Pugh and model for end stage liver disease (MELD)-Na scores. In addition, ΔSMI/yr% showed a good predictive performance for the development of cirrhosis complications within 6 months after 1-year follow-up in all subgroups, with a cut-off of -2.62 (sensitivity, 83.9%; specificity, 74.5%) in the overall population. SMI at 1-year and Child-Pugh score were independent factors associated with survival. In addition, changes in sarcopenia status significantly stratified survival.
Conclusion ΔSMI/yr% was a good predictor of the development of cirrhosis complications in outpatients with cirrhosis, independent of Child-Pugh and MELD scores.
Citations
Citations to this article as recorded by
Impact of year-to-year changes in skeletal muscle mass on the prediction of long-term survival in patients with liver cirrhosis Fulian Zhao, Ruojing Wang, Chengbin Zhu, Chang Zhang, Tianzhi Ni, Qijuan Zang, Yali Feng, Mengmeng Zhang, Li Zhu, Yage Zhu, Juan Du, Zhe Jiao, Chenxia Li, Taotao Yan, Yingli He, Yuchao Wu, Yingren Zhao, Yuan Yang Nutrition.2026; 142: 112982. CrossRef
Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis Zhang Wen, Shuyue Tuo, Qiuju Ran, Jia Yuan, Yong Li, Ying Zhang, Danyan Chang, Chan Li, Shejiao Dai, Jinhai Wang, Xinxing Tantai Annals of Medicine.2025;[Epub] CrossRef
Assessment of Sarcopenia in Patients with Liver Cirrhosis—A Literature Review Dorotea Bozic, Bisera Mamic, Iva Peric, Ivona Bozic, Ivan Zaja, Tomislav Ivanovic, Ana Gugic Ratkovic, Ivica Grgurevic Nutrients.2025; 17(16): 2589. CrossRef
Predictive performance of distinct skeletal muscle index cut-offs-defined sarcopenia for long-term mortality in decompensated cirrhosis: A prospective observational study Chao Sun, Han Wang, Ziyi Yang, Huanli Jiao European Journal of Radiology.2025; 192: 112396. CrossRef
Prevalence of and associated factors for sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis Shuyue Tuo, Yee Hui Yeo, Rachel Chang, Zhang Wen, Qiuju Ran, Longbao Yang, Qing Fan, Junxiu Kang, Jiaojiao Si, Yi Liu, Haitao Shi, Yong Li, Jia Yuan, Na Liu, Shejiao Dai, Xiaoyan Guo, Jinhai Wang, Fanpu Ji, Xinxing Tantai Clinical Nutrition.2024; 43(1): 84. CrossRef
Correlation between sarcopenia and cirrhosis: a meta-analysis Yifan Cui, Mingming Zhang, Jing Guo, Jin Jin, Haijiao Wang, Xinran Wang Frontiers in Nutrition.2024;[Epub] CrossRef
Sarcopenia increases mortality risk in liver transplantation: a systematic review and meta-analysis Konstantinos PROKOPIDIS, Marco AFFRONTI, Giuseppe D. TESTA, Andrea UNGAR, Emanuele CEREDA, Lee SMITH, Francesco PEGREFFI, Mario BARBAGALLO, Nicola VERONESE Panminerva Medica.2024;[Epub] CrossRef
Sarcopenia evaluated by EASL/AASLD computed tomography-based criteria predicts mortality in patients with cirrhosis: A systematic review and meta-analysis Elton Dajti, Susana G. Rodrigues, Federica Perazza, Luigi Colecchia, Giovanni Marasco, Matteo Renzulli, Giovanni Barbara, Francesco Azzaroli, Annalisa Berzigotti, Antonio Colecchia, Federico Ravaioli JHEP Reports.2024; 6(8): 101113. CrossRef
Appendicular Skeletal Muscle Mass to Visceral Fat Area Ratio Predicts Hepatic Morbidities Eugene Han, Yong-ho Lee, Sang Hoon Ahn, Bong-Soo Cha, Seung Up Kim, Byung-Wan Lee Gut and Liver.2024; 18(3): 509. CrossRef
Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis Tatsunori Hanai, Kayoko Nishimura, Shinji Unome, Takao Miwa, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu Journal of Gastroenterology.2024; 59(10): 932. CrossRef
Muscle mass dynamics is independently associated with long-term liver-related mortality in patients with cirrhosis Jiarui Zheng, Shuo Yang, Wenhui Ren, Juan Zhong, Xin Liu, Rui Han, Tingyang Wei, Changjie Tie, Yuteng Yang, Chengwu Hong, Bo Feng, Rui Huang Heliyon.2024; 10(15): e35354. CrossRef
Accelerated muscle mass estimation from CT images through transfer learning Seunghan Yoon, Tae Hyung Kim, Young Kul Jung, Younghoon Kim BMC Medical Imaging.2024;[Epub] CrossRef
Psoas muscle index in sarcopenia following transjugular intrahepatic portosystemic shunt: A multicenter, retrospective study Tongqiang Li, Ze Wang, Yang Liu, Liguo Dai, Xiaoli Zhu, Jiacheng Liu, Qikun Guo, Weijie Luo, Yaowei Bai, Wei Luo, Menglan Chu, Duiping Feng, Bin Xiong Portal Hypertension & Cirrhosis.2024; 3(4): 173. CrossRef
Correspondence on Letter regarding “Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis” Tae Hyung Kim, Young Kul Jung, Hyung Joon Yim Clinical and Molecular Hepatology.2023; 29(1): 173. CrossRef
Letter regarding “Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis” Do Seon Song, U Im Chang, Jin Mo Yang Clinical and Molecular Hepatology.2023; 29(1): 165. CrossRef
Interaction between sarcopenia and nonalcoholic fatty liver disease Sae Kyung Joo, Won Kim Clinical and Molecular Hepatology.2023; 29(Suppl): S68. CrossRef
MAFLD might be better in identifying subjects with sarcopenia or cardiovascular risk than NAFLD: A nationwide study Eugene Han, Ho Soo Chun, Yong‐ho Lee, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Byung‐Wan Lee, Eun Seok Kang, Bong‐Soo Cha, Sang Hoon Ahn, Seung Up Kim Journal of Gastroenterology and Hepatology.2023; 38(9): 1598. CrossRef
Sarcopenia in cirrhosis: Prospects for therapy targeted to gut microbiota Roman Maslennikov, Aliya Alieva, Elena Poluektova, Yury Zharikov, Andrey Suslov, Yana Letyagina, Ekaterina Vasileva, Anna Levshina, Evgenii Kozlov, Vladimir Ivashkin World Journal of Gastroenterology.2023; 29(27): 4236. CrossRef
Pretransplant Functional Status Predicts Postoperative Morbidity and Mortality after Liver Transplantation in Patients with Cirrhosis Myung Ji Goh, Jihye Kim, Won Hyuk Chang, Dong Hyun Sinn, Geum-Yeon Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Jong Man Kim, Wonseok Kang Gut and Liver.2023; 17(5): 786. CrossRef
Correspondence on Letter regarding “COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis” Ka Shing Cheung, Chiu Hang Mok, Wai Kay Seto, Man Fung Yuen Clinical and Molecular Hepatology.2023; 29(1): 176. CrossRef
SARS-CoV-2 and chronic hepatitis B: Focusing on the possible consequences of co-infection Shahrzad Shoraka, Seyed Reza Mohebbi, Seyed Masoud Hosseini, Amir Ghaemi, Mohammad Reza Zali Journal of Clinical Virology Plus.2023; 3(4): 100167. CrossRef
Post-COVID-19 cholangiopathy: Systematic review Mazen Abdalla Rasheed, Vinícius Remus Ballotin, Lucas Goldmann Bigarella, Jonathan Soldera World Journal of Methodology.2023; 13(4): 296. CrossRef
Han Ah Lee, Young Chang, Pil Soo Sung, Eileen L. Yoon, Hye Won Lee, Jeong-Ju Yoo, Young-Sun Lee, Jihyun An, Do Seon Song, Young Youn Cho, Seung Up Kim, Yoon Jun Kim
Clin Mol Hepatol 2022;28(3):425-472. Published online July 1, 2022
The global burden of chronic liver disease (CLD) is substantial. Due to the limited indication of and accessibility to antiviral therapy in viral hepatitis and lack of effective pharmacological treatment in nonalcoholic fatty liver disease, the beneficial effects of antidiabetics and non–antidiabetics in clinical practice have been continuously investigated in patients with CLD. In this narrative review, we focused on non-antidiabetic drugs, including ursodeoxycholic acid, silymarin, dimethyl4,4’-dimethoxy-5,6,5’,6’-dimethylenedixoybiphenyl-2,2’-dicarboxylate, L-ornithine L-aspartate, branched chain amino acids, statin, probiotics, vitamin E, and aspirin, and summarized their beneficial effects in CLD. Based on the antioxidant, anti-inflammatory properties, and regulatory functions in glucose or lipid metabolism, several non–antidiabetic drugs have shown beneficial effects in improving liver histology, aminotransferase level, and metabolic parameters and reducing risks of hepatocellular carcinoma and mortality, without significant safety concerns, in patients with CLD. Although the effect as the centerpiece management in patients with CLD is not robust, the use of these non-antidiabetic drugs might be potentially beneficial as an adjuvant or combined treatment strategy.
Citations
Citations to this article as recorded by
CYP4A14-PPARα axis serves as a therapeutic target for ursodeoxycholic acid in ameliorating high-fat diet-induced MASLD Bing Li, Pengjun Zhong, Xueling Zhang, Chengguo Li, Min Luan, Yanlin Chen, Lei Chen, Wu Li, Rihui Wu The Journal of Nutritional Biochemistry.2026; 147: 110138. CrossRef
An in vitro 3D spheroid model with liver steatosis and fibrosis on microwell arrays for drug efficacy evaluation Jiamin Chen, Ping Wang, Zhanpeng Li, Jieyi Wu, Fang Tang, Niao Yang, Bohong Cen, Cuiyin Xie, Yufan Yang, Ziyan Yang, Chuwen Zhang, Xiangcao Yao, Zhongyuan Xu Journal of Biotechnology.2025; 399: 153. CrossRef
KASL clinical practice guidelines for the management of metabolic dysfunction-associated steatotic liver disease 2025 Won Sohn, Young-Sun Lee, Soon Sun Kim, Jung Hee Kim, Young-Joo Jin, Gi-Ae Kim, Pil Soo Sung, Jeong-Ju Yoo, Young Chang, Eun Joo Lee, Hye Won Lee, Miyoung Choi, Su Jong Yu, Young Kul Jung, Byoung Kuk Jang Clinical and Molecular Hepatology.2025; 31(Suppl): S1. CrossRef
Pharmacotherapy in metabolic-dysfunction-associated steatotic liver disease: an updated review of the past, present and a promising future Sunetra Mondal, Amarta Shankar Chowdhury, Rajat Deb, Debmalya Sanyal Diabetology International.2025; 16(4): 678. CrossRef
Polymer-engineered delivery systems for Schisandra lignans: A review of advances in hepatic-targeted therapy Jia Zhou, Jiyuan Zhang, Jinzhuan Xu, Man Zhang, Yuanxing Huang, Zhengli Zhou, Hexinchen Tian, Jing Huang, Jianqing Peng, Runbin Sun, Yi Chen, Zipeng Gong International Journal of Biological Macromolecules.2025; 323: 147083. CrossRef
Letter on ‘Long‐Term Dynamic Changes of Alanine Aminotransferase Levels Are Associated With Liver‐Related Events in Nucleos(t)ide Analogue‐Treated Chronic Hepatitis B Patients in China’ Dong Hyun Kim, Hye Won Lee Alimentary Pharmacology & Therapeutics.2025; 62(9): 954. CrossRef
Modulation of Amomum tsao-ko on lipid metabolism and gut microbiota in high-fat diet-fed mice with NAFLD Zezhu Du, Lijun Yu, Jinya Dong, Linxian Shan, Jun He, Yan Shen, Yanmei Li, Xiuli Lu, Shengjie Duan, Jianyang Fu, Xiaocui Du, Yunfei Ge, Ruijuan Yang, Chongye Fang Journal of Agriculture and Food Research.2025; 24: 102379. CrossRef
Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review Hafiza Madiha Jaffar, Fahad Al‐Asmari, Faima Atta Khan, Muhammad Abdul Rahim, Eliasse Zongo Food Science & Nutrition.2024; 12(5): 3097. CrossRef
The additive effect of herbal medicines on lifestyle modification in the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis Myung-Ho Kim, Subin Ahn, Nayeon Hur, Seung-Yun Oh, Chang-Gue Son Frontiers in Pharmacology.2024;[Epub] CrossRef
Association between ursodeoxycholic acid use and COVID-19 in individuals with chronic liver disease: a nationwide case-control study in South Korea Sang Yi Moon, Minkook Son, Yeo Wool Kang, Myeongseok Koh, Jong Yoon Lee, Yang Hyun Baek Virology Journal.2024;[Epub] CrossRef
Evaluating the Role of Aspirin in Liver Disease: Efficacy, Safety, Potential Benefits and Risks Amani Elshaer, Blanca C. Lizaola-Mayo Life.2024; 14(12): 1701. CrossRef
Vitamin E and Pioglitazone: A Comprehensive Systematic Review of Their Efficacy in Non-alcoholic Fatty Liver Disease Iqra J Mazhar, Mohamed Yasir, Saba Sarfraz, Gandhala Shlaghya, Sri Harsha Narayana, Ujala Mushtaq, Basim Shaman Ameen, Chuhao Nie, Daniel Nechi, Sai Sri Penumetcha Cureus.2023;[Epub] CrossRef
ALT Is Not Associated With Achieving Subcirrhotic Liver Stiffness and HCC During Entecavir Therapy in HBV-Related Cirrhosis Mi Na Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Se Young Jang, Won Young Tak, Young-Oh Kweon, Soo Young Park, Seung Up Kim Clinical Gastroenterology and Hepatology.2023; 21(9): 2278. CrossRef
Case 9: A 62-Year-Old Woman With Jaundice and General Weakness Hee Sun Cho, Ji Won Han, Ji Hoon Kim, Heechul Nam, Pil Soo Sung, Si Hyun Bae Journal of Korean Medical Science.2023;[Epub] CrossRef
Visión actual sobre el diagnóstico y los cuidados integrales en la encefalopatía hepática F. Higuera-de-la-Tijera, J.A. Velarde-Ruiz Velasco, R.H. Raña-Garibay, G.E. Castro-Narro, J.M. Abdo-Francis, R. Moreno-Alcántar, J.L. Pérez-Hernández, A. Torre, R. Contreras-Omaña, A. Cano-Contreras, M. Castillo-Barradas, J. Pérez-Escobar, J.M. Aldana-Led Revista de Gastroenterología de México.2023; 88(2): 155. CrossRef
Current vision on diagnosis and comprehensive care in hepatic encephalopathy F. Higuera-de-la-Tijera, J.A. Velarde-Ruiz Velasco, R.H. Raña-Garibay, G.E. Castro-Narro, J.M. Abdo-Francis, R. Moreno-Alcántar, J.L. Pérez-Hernández, A. Torre, R. Contreras-Omaña, A. Cano-Contreras, M. Castillo-Barradas, J. Pérez-Escobar, J.M. Aldana-Led Revista de Gastroenterología de México (English Edition).2023; 88(2): 155. CrossRef
Multiple Hepatic Artery Pseudoaneurysms With Eosinophilia Mun Young Cho, Pil Soo Sung, Sung Hak Lee Gastroenterology.2023; 165(4): 843. CrossRef
Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim Cell Communication and Signaling.2023;[Epub] CrossRef
Forecasted 2040 global prevalence of nonalcoholic fatty liver disease using hierarchical bayesian approach Michael H. Le, Yee Hui Yeo, Biyao Zou, Scott Barnet, Linda Henry, Ramsey Cheung, Mindie H. Nguyen Clinical and Molecular Hepatology.2022; 28(4): 841. CrossRef
CSAD Ameliorates Lipid Accumulation in High-Fat Diet-Fed Mice Rongrong Tan, Jiayang Li, Lu Liu, Qian Wu, Lei Fan, Ningning Ma, Chuwei Yu, Henglei Lu, Xuemei Zhang, Jing Chen, Likun Gong, Jin Ren International Journal of Molecular Sciences.2022; 23(24): 15931. CrossRef
Genotype–Phenotype Association in ABCC2 Exon 18 Missense Mutation Leading to Dubin–Johnson Syndrome: A Case Report Ji-Hoon Kim, Min-Woo Kang, Sangmi Kim, Ji Won Han, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Pil Soo Sung International Journal of Molecular Sciences.2022; 23(24): 16168. CrossRef
Correspondence on Letter regarding “COVID-19 vaccine immunogenicity among chronic liver disease patients and liver transplant recipients: A meta-analysis” Ka Shing Cheung, Chiu Hang Mok, Wai Kay Seto, Man Fung Yuen Clinical and Molecular Hepatology.2023; 29(1): 176. CrossRef
SARS-CoV-2 Infection and Liver Disease: A Review of Pathogenesis and Outcomes Luke Baldelli, Thomas Marjot, Eleanor Barnes, A. Sidney Barritt, Gwilym J. Webb, Andrew M. Moon Gut and Liver.2023; 17(1): 12. CrossRef
Analysis of Antibody Responses After COVID-19 Vaccination in Liver Transplant Recipients: A Single-Center Study Young Ju Oh, Jongman Kim, Eun-Suk Kang, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh Journal of Korean Medical Science.2023;[Epub] CrossRef
Acute Budd‐Chiari syndrome with thrombotic thrombocytopenia after BNT162b2 mRNA vaccination Pil S. Sung, Jung S. Oh, Joon‐Il Choi Liver International.2022; 42(6): 1447. CrossRef
Forms of cholangitis to be considered after SARS-CoV-2 infection Ju-Yeon Cho, Young-Sun Lee, Soon Sun Kim, Do Seon Song, Jeong-Hoon Lee, Ji Hoon Kim Clinical and Molecular Hepatology.2022; 28(4): 929. CrossRef
Autoimmune liver disease represented as primary biliary cholangitis after SARS-CoV-2 infection: A need for population-based cohort study Soon Kyu Lee, Jung Hyun Kwon, Nara Yoon, Soon Woo Nam, Pil Soo Sung Clinical and Molecular Hepatology.2022; 28(4): 926. CrossRef
Han Ah Lee, Jihwan Lim, Hyung Joon Joo, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Yoon Tae Jeen, Jong Eun Yeon, Do-Sun Lim, Kwan Soo Byun, Yeon Seok Seo
Clin Mol Hepatol 2021;27(3):463-473. Published online February 15, 2021
Background/Aims Useful biomarkers for metabolic syndrome have been insufficient. We investigated the performance of serum milk fat globule-EGF factor-8 (MFG-E8), the key mediator of inflammatory pathway, in diagnosis of metabolic syndrome.
Methods Subjects aged between 30 and 64 years were prospectively enrolled in the Seoul Metabolic Syndrome cohort. Serum MFG-E8 levels were measured at baseline.
Results A total of 556 subjects were included, comprising 279 women (50.2%) and 277 men (49.8%). Metabolic syndrome was diagnosed in 236 subjects (42.4%), and the mean MFG-E8 level of subjects with metabolic syndrome was significantly higher than that of subjects without metabolic syndrome (P<0.001). MFG-E8 level was significantly correlated with all metabolic syndrome components and pulse wave velocity (all P<0.05). Subjects were categorized into two groups according to the best MFG-E8 cut-off value as follows: group 1, MFG-E8 level <4,745.1 pg/mL (n=401, 72.1%); and group 2, MFG-E8 level ≥4,745.1 (n=155, 27.9%). At baseline, metabolic syndrome in group 2 was significantly more prevalent than in group 1 (63.9% vs. 34.2%, P<0.001). During median follow-up of 17 months, metabolic syndrome developed in 122 (38.1%) subjects among 320 subjects without it at baseline. The incidence of metabolic syndrome in group 2 was significantly higher than that in group 1 (55.4% vs. 34.5%, P=0.003). On multivariate analysis, MFG-E8 level ≥4,745.1 pg/mL was an independent predictor for diagnosis and development of metabolic syndrome after adjusting other factors (all P<0.05).
Conclusions Serum MFG-E8 level is a potent biomarker for the screening and prediction of metabolic syndrome.
Citations
Citations to this article as recorded by
Exploring the potential of MFG-E8 in neurodegenerative diseases Dan Li, Wang Rongchun, Weihong Lu, Ying Ma Critical Reviews in Food Science and Nutrition.2025; 65(28): 5565. CrossRef
Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice Volodymyr P. Tryndyak, Rose A. Willett, Zhuolin Song, Kostiantyn Dreval, Jennifer M. Hughes Hanks, Mark I. Avigan, Fred A. Wright, Frederick A. Beland, Ivan Rusyn, Igor P. Pogribny Toxicology and Applied Pharmacology.2025; 502: 117442. CrossRef
Elevated circulating HHIP levels in patients with metabolic syndrome Jingwei Lei, Yu Yang, Yerui Lai, Dongfang Liu, Cong Wang, Weiwei Xu, Ke Li, Shengbing Li, Mengliu Yang, Ling Li Biochemical and Biophysical Research Communications.2024; 736: 150877. CrossRef
Proteomic profiling of serum identifies a molecular signature that correlates with clinical outcomes in COPD Rania Dagher, Paul Fogel, Jingya Wang, David Soussan, Chia-Chien Chiang, Jennifer Kearley, Daniel Muthas, Camille Taillé, Patrick Berger, Arnaud Bourdin, Cécile Chenivesse, Sylvie Leroy, Gary Anderson, Alison A. Humbles, Michel Aubier, Roland Kolbeck, Mar PLOS ONE.2022; 17(12): e0277357. CrossRef
Impact of Coronavirus Disease 2019 on Unresectable Hepatocellular Carcinoma Treated with Atezolizumab/Bevacizumab Yun Beom Sang, Chaeryoung Lee, Seul-Gi Kim, Boyoung Lee, Beodeul Kang, Chan Kim, Hong Jae Chon Journal of Clinical Medicine.2024; 13(5): 1335. CrossRef
SARS-CoV-2 Infection and Liver Disease: A Review of Pathogenesis and Outcomes Luke Baldelli, Thomas Marjot, Eleanor Barnes, A. Sidney Barritt, Gwilym J. Webb, Andrew M. Moon Gut and Liver.2023; 17(1): 12. CrossRef
Autoimmune liver disease represented as primary biliary cholangitis after SARS-CoV-2 infection: A need for population-based cohort study Soon Kyu Lee, Jung Hyun Kwon, Nara Yoon, Soon Woo Nam, Pil Soo Sung Clinical and Molecular Hepatology.2022; 28(4): 926. CrossRef
Forms of cholangitis to be considered after SARS-CoV-2 infection Ju-Yeon Cho, Young-Sun Lee, Soon Sun Kim, Do Seon Song, Jeong-Hoon Lee, Ji Hoon Kim Clinical and Molecular Hepatology.2022; 28(4): 929. CrossRef
Management of Patients with Chronic Liver Disease: The Era of the COVID-19 Pandemic Yu Rim Lee The Korean Journal of Gastroenterology.2021; 77(4): 156. CrossRef
Update on liver disease management during the pandemic of coronavirus disease 2019 (COVID-19): 2021 KASL guideline Ju-Yeon Cho, Young-Sun Lee, Soon Sun Kim, Do Seon Song, Jeong-Hoon Lee, Ji Hoon Kim Clinical and Molecular Hepatology.2021; 27(4): 515. CrossRef
Maintaining standard volumes, efficacy and safety, of fecal microbiota transplantation for C. difficile infection during the COVID-19 pandemic: A prospective cohort study Gianluca Ianiro, Stefano Bibbò, Luca Masucci, Gianluca Quaranta, Serena Porcari, Carlo Romano Settanni, Loris Riccardo Lopetuso, Massimo Fantoni, Maurizio Sanguinetti, Antonio Gasbarrini, Giovanni Cammarota Digestive and Liver Disease.2020; 52(12): 1390. CrossRef
Tae Suk Kim, Ji Hoon Kim, Baek hui Kim, Young-Sun Lee, Yang Jae Yoo, Seong Hee Kang, Sang-June Suh, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun
Clin Mol Hepatol 2017;23(4):340-346. Published online June 20, 2017
Since sorafenib was introduced in 2007 for treating advanced hepatocellular carcinoma (HCC), 15 patients have achieved a complete response (CR) in advanced HCC. However, only four of these reports can be regarded as real CRs involving adequate assessments including imaging, serum tumor markers, and histologic examinations of completely resected specimens. A 54-year-old man with hepatitis C virus (HCV)-related liver cirrhosis (LC) presented to our unit. A CT scan demonstrated a 3.8-cm arterial hypervascular/portal-washout mass in the right lobe and invasion in the right portal vein. Twelve weeks after beginning sorafenib therapy, the AFP level was normalized and a CT scan showed a prominent decrease in the hepatic mass and a significant decrease in the volume of portal vein thrombosis (PVT). The patient received a right liver hemihepatectomy after 12 months. No viable tumor cells were found in the resected specimen, and there was no thrombotic obstruction of the portal vein. Twelve months later the patient showed no clinical evidence of HCC recurrence. This is the first case of CR in HCC treatment following sorafenib with histologically confirmed HCVrelated HCC without LC evidence, HCC with PVT, and a follow-up of longer than 12 months. This case seems to be an extremely unusual clinical outcome in advanced HCC.
Citations
Citations to this article as recorded by
The novel predictive nomograms for early death in metastatic hepatocellular carcinoma: A large cohort study Yue Wang, Long Ge, Yan Cai Medicine.2024; 103(1): e36812. CrossRef
Liver resection and transplantation in the era of checkpoint inhibitors Parissa Tabrizian, Rebecca Marino, Pierce K.H. Chow JHEP Reports.2024; 6(11): 101181. CrossRef
Sorafenib as first-line treatment for patients with primary hepatocellular carcinoma: an outcome evaluation Dung Thi Nguyen, Duong Hoang Nguyen, Van Thi Hong Nguyen Journal of International Medical Research.2023;[Epub] CrossRef
Automatic prediction of hepatic arterial infusion chemotherapy response in advanced hepatocellular carcinoma with deep learning radiomic nomogram Ziming Xu, Chao An, Feng Shi, He Ren, Yuze Li, Song Chen, Jiaqi Dou, Yajie Wang, Shaozhen Yan, Jie Lu, Huijun Chen European Radiology.2023; 33(12): 9038. CrossRef
Conversion surgery after preoperative therapy for advanced hepatocellular carcinoma in the era of molecular targeted therapy and immune checkpoint inhibitors Junichi Arita, Akihiko Ichida, Rihito Nagata, Yuichiro Mihara, Yoshikuni Kawaguchi, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Kiyoshi Hasegawa Journal of Hepato-Biliary-Pancreatic Sciences.2022; 29(7): 732. CrossRef
Durable objective response to sorafenib and role of sequential treatment in unresectable hepatocellular carcinoma Kuo-Wei Huang, Pei-Chang Lee, Yee Chao, Chien-Wei Su, I-Cheng Lee, Keng-Hsin Lan, Chi-Jen Chu, Yi-Ping Hung, San-Chi Chen, Ming-Chih Hou, Yi-Hsiang Huang Therapeutic Advances in Medical Oncology.2022;[Epub] CrossRef
A Practical Nomogram and Risk Stratification System Predicting the Cancer-Specific Survival for Patients With Advanced Hepatocellular Carcinoma Dashuai Yang, Yang Su, Fangrui Zhao, Chen Chen, Kailiang Zhao, Xiangyun Xiong, Youming Ding Frontiers in Oncology.2022;[Epub] CrossRef
Lenvatinib is independently associated with the reduced risk of progressive disease when compared with sorafenib in patients with advanced hepatocellular carcinoma Soojin Kim, Kyung Hyun Kim, Beom Kyung Kim, Jun Yong Park, Sang Hoon Ahn, Do Young Kim, Seung Up Kim Journal of Gastroenterology and Hepatology.2021; 36(5): 1317. CrossRef
Outcomes of reduction hepatectomy combined with postoperative multidisciplinary therapy for advanced hepatocellular carcinoma Yoh Asahi, Toshiya Kamiyama, Tatsuhiko Kakisaka, Tatsuya Orimo, Shingo Shimada, Akihisa Nagatsu, Takeshi Aiyama, Yuzuru Sakamoto, Hirofumi Kamachi, Akinobu Taketomi World Journal of Gastrointestinal Surgery.2021; 13(10): 1245. CrossRef
Complete Pathological Response of Hepatocellular Carcinoma with Portal Vein Thrombosis Treated with Sorafenib—Report of a Case— Tetsushi MIZUTANI, Mizuo HASHIMOTO, Hiroaki USUI, Tomoki KOBAYASHI, Motonobu NISHIMURA, Kenji SAKAGUCHI Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2021; 82(3): 635. CrossRef
Modeling Hepatocellular Carcinoma Cells Dynamics by Serological and Imaging Biomarkers to Explain the Different Responses to Sorafenib and Regorafenib Piero Colombatto, Coskun Ozer Demirtas, Gabriele Ricco, Luigi Civitano, Piero Boraschi, Paola Scalise, Daniela Cavallone, Filippo Oliveri, Veronica Romagnoli, Patrizia Bleve, Barbara Coco, Antonio Salvati, Lucio Urbani, Ferruccio Bonino, Maurizia Rossana Cancers.2021; 13(9): 2064. CrossRef
Laparoscopic bypass surgery as palliative treatment for duodenal obstruction due to lymph node metastasis invasion of hepatocellular carcinoma Akane Kurosugi, Tetsuhiro Chiba, Terunao Iwanaga, Hidemi Unozawa, Takafumi Sakuma, Naoto Fujita, Kengo Kanayama, Hiroaki Kanzaki, Keisuke Koroki, Kazufumi Kobayashi, Soichiro Kiyono, Ryo Nakagawa, Naoya Kanogawa, Masato Nakamura, Takayuki Kondo, Tomoko Sa Kanzo.2021; 62(10): 656. CrossRef
Sorafenib Treatment has the Potential to Downstage Advanced Hepatocellular Carcinoma before Liver Resection Alessandra Bertacco, Alessandro Vitale, Claudia Mescoli, Umberto Cillo Personalized Medicine.2020; 17(2): 83. CrossRef
A case report: Long-term complete response of metastatic hepatocellular carcinoma obtained after discontinuation of 2-month sorafenib monotherapy Suguru Hirose, Kazunori Ishige, Masamichi Yamaura, Tsuneo Mizui, Yoshiki Komatsu, Masaomi Nagase, Masashi Sato, Junji Hattori, Masato Endo, Naoyuki Hasegawa, Kuniaki Fukuda, Ichinosuke Hyodo Clinical Journal of Gastroenterology.2020; 13(5): 902. CrossRef
MTL-CEBPA, a Small Activating RNA Therapeutic Upregulating C/EBP-α, in Patients with Advanced Liver Cancer: A First-in-Human, Multicenter, Open-Label, Phase I Trial Debashis Sarker, Ruth Plummer, Tim Meyer, Mikael H. Sodergren, Bristi Basu, Cheng Ean Chee, Kai-Wen Huang, Daniel H. Palmer, Yuk Ting Ma, T.R. Jeff Evans, Duncan R.C. Spalding, Madhava Pai, Rohini Sharma, David J. Pinato, James Spicer, Sarah Hunter, Vinee Clinical Cancer Research.2020; 26(15): 3936. CrossRef
Preclinical efficacy of a novel dual PI3K/mTOR inhibitor, CMG002, alone and in combination with sorafenib in hepatocellular carcinoma Mi Na Kim, Seung Min Lee, Jin Sung Kim, Seong Gyu Hwang Cancer Chemotherapy and Pharmacology.2019; 84(4): 809. CrossRef
Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model Yan Li, Ira Agrawal, Zhiyuan Gong Disease Models & Mechanisms.2019;[Epub] CrossRef
Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases Giovanni Brandi, Michela Venturi, Stefania De Lorenzo, Francesca Garuti, Giorgio Frega, Andrea Palloni, Ingrid Garajovà, Francesca Abbati, Gioconda Saccoccio, Rita Golfieri, Maria Abbondanza Pantaleo, Maria Aurelia Barbera Cancer Communications.2018; 38(1): 1. CrossRef
Long-term remission in advanced stage hepatocellular carcinoma? A chance for cure? Matthias Pinter, Wolfgang Sieghart memo - Magazine of European Medical Oncology.2018; 11(3): 185. CrossRef
First
Prev
