Background/Aims The role of serum myokine levels in sarcopenia and the outcome of hepatocellular carcinoma (HCC) patients are not clear. This study investigated the serum levels of myostatin, follistatin, and interleukin-6 (IL-6) in HCC patients and their association with sarcopenia and survival.
Methods Using prospectively collected pretreatment samples from 238 HCC patients in a hospital from 2012 to 2015, the serum levels of 3 myokines were determined and compared to 50 samples from age and sex-matched healthy controls. Sarcopenia was evaluated using the psoas muscle index (PMI) measured at the third lumbar level in the computed tomography, and clinical data were collected until 2017.
Results The median levels of the 3 myokines for the male and female HCC patients were as follow: myostatin (3,979.3 and 2,976.3 pg/mL), follistatin (2,118.5 and 2,174.6 pg/mL), and IL-6 (2.5 and 2.7 pg/mL), respectively. Those in the HCC patients were all significantly higher than in the healthy controls. In the HCC patient, the median PMI was 4.43 (males) and 2.17 cm2/m2 (females) with a sarcopenic prevalence of 56.4%. The serum levels of myostatin, IL-6 and follistatin in the HCC patients showed a positive, negative, and no correlation with PMI, respectively. The serum follistatin level was an independent factor for poor survival in HCC patients.
Conclusions The serum levels of myostatin, follistatin, and IL-6 and their correlation with sarcopenia and survival were presented in HCC patients for the first time. The role of the serum follistatin level as a poor prognostic biomarker warrants further study.
Citations
Citations to this article as recorded by
The Role of Myokines in Liver Diseases Hiroki Nishikawa, Soo Ki Kim, Akira Asai International Journal of Molecular Sciences.2025; 26(3): 1043. CrossRef
Changes in serum myostatin levels among patients with type C liver cirrhosis treated with direct‐acting antivirals Tomoyuki Suehiro, Hideko Kozuru, Kosuke Matusmoto, Yuki Kugiyama, Yasuhide Motoyoshi, Akira Saeki, Shinya Nagaoka, Kazumi Yamasaki, Atsumasa Komori, Hiroshi Yatsuhashi Hepatology Research.2025; 55(5): 631. CrossRef
The emerging role of exercise preconditioning in preventing skeletal muscle atrophy Xu Zhou, Shiming Li, Lu Wang, Jun Wang, Peng Zhang, Xiaoping Chen Frontiers in Physiology.2025;[Epub] CrossRef
New insights into biomarkers and risk stratification to predict hepatocellular cancer Katrina Li, Brandon Mathew, Ethan Saldanha, Puja Ghosh, Adrian R. Krainer, Srinivasan Dasarathy, Hai Huang, Xiyan Xiang, Lopa Mishra Molecular Medicine.2025;[Epub] CrossRef
The association between shorter disease course and sarcopenia in women with endometriosis: a retrospective analysis of NHANES 1999–2006 Litao Sun, Yishu Tian, Lei Ling Scientific Reports.2025;[Epub] CrossRef
State-of-the-art insights into myokines as biomarkers of sarcopenia: a literature review Omar R Moussaoui International Journal of Physiology, Pathophysiology and Pharmacology.2025; 17(3): 80. CrossRef
Myokine Circulating Levels in Postmenopausal Women with Overweight or Obesity: Effects of Resistance Training and/or DHA-Rich n-3 PUFA Supplementation Alejandro Martínez-Gayo, Elisa Félix-Soriano, Javier Ibáñez-Santos, Marisol García-Unciti, Pedro González-Muniesa, María J. Moreno-Aliaga Nutrients.2025; 17(15): 2553. CrossRef
Exerkines and myokines in aging sarcopenia Huan Wang, Wenbi He, Peishan Chen, Haozhe Wang, Huiguo Wang, Lin Zhu, Xiaoguang Liu Frontiers in Endocrinology.2025;[Epub] CrossRef
Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jin Ju Lim, Yeong Hoon Kang, Ji Wook Moon, Jeong Min Nam, Jeong Hyeon Kim, Donghun Kim, Jae Ho Shim, Hyeon Soo Kim Journal of Cachexia, Sarcopenia and Muscle.2025;[Epub] CrossRef
Associations Among Skeletal Muscle Mass, Bone Mineral Density, and Cardiometabolic Risk Factors in Young and Middle-Aged Adults Yeonhwi Kim, Minje Ji, Sewon Lee Exercise Science.2025; 34(3): 308. CrossRef
Alterations in the Myokine Concentrations in Relation to Sarcopenia and Sleep Disturbances: A Narrative Review Michalina Knapik, Jakub Kuna, Grzegorz Chmielewski, Łukasz Jaśkiewicz, Magdalena Krajewska-Włodarczyk Journal of Clinical Medicine.2025; 14(18): 6527. CrossRef
A non-invasive decision tree predicting recurrence-free survival after liver transplantation for hepatocellular carcinoma Mo-Dan Yang, Jian-Yong Zhuo, Guo-Ying Wang, Li Zhuang, Xiao Xu, Shu-Sen Zheng, Yang Yang, Di Lu Hepatobiliary & Pancreatic Diseases International.2025;[Epub] CrossRef
Diabetes Mellitus Should Be Considered While Analysing Sarcopenia-Related Biomarkers Justyna Rentflejsz, Zyta Beata Wojszel Journal of Clinical Medicine.2024; 13(4): 1107. CrossRef
Myostatin and Activin A as Biomarkers of Sarcopenia in Inflammatory Bowel Disease Patients Małgorzata Godala, Ewelina Gaszyńska, Konrad Walczak, Ewa Małecka-Wojciesko Nutrients.2024; 16(6): 810. CrossRef
Hepatocellular carcinoma and musculoskeletal system: A narrative literature review Jelena Jadzic, Danijela Djonic World Journal of Gastroenterology.2024; 30(15): 2109. CrossRef
Role of Myostatin in Rheumatoid Arthritis: A Review of the Clinical Impact Fabiola Gonzalez-Ponce, Melissa Ramirez-Villafaña, Eli Efrain Gomez-Ramirez, Ana Miriam Saldaña-Cruz, Sergio Gabriel Gallardo-Moya, Norma Alejandra Rodriguez-Jimenez, Heriberto Jacobo-Cuevas, Cesar Arturo Nava-Valdivia, Felipe Alexis Avalos-Salgado, Sylvi Diagnostics.2024; 14(11): 1085. CrossRef
Exploring the impact of interleukins on sarcopenia development: A systematic review and meta-analysis Yan He, Wenrong Duan, Ping Xu, Taiping Lin, Qiao Xiang, Birong Dong, Ning Ge, Jirong Yue Experimental Gerontology.2024; 193: 112480. CrossRef
Circulating myostatin as a biomarker of muscle mass and strength in individuals with cancer or obesity Laura Orioli, Sofia Samaras, Kiswendsida Sawadogo, Marie de Barsy, Pascale Lause, Yannick Deswysen, Benoit Navez, Jean-Paul Thissen, Audrey Loumaye Clinical Nutrition.2024; 43(7): 1800. CrossRef
Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal Study Hsiao-Chin Shen, Wei-Ju Lee, Chuan-Yen Sun, Wen-Kuang Yu, Wei-Chih Chen, Fei-Yuan Hsiao, Kuang-Yao Yang, Liang-Kung Chen The Journal of nutrition, health and aging.2024; 28(8): 100285. CrossRef
Epigenetics of Skeletal Muscle Atrophy Jiacheng Du, Qian Wu, Eun Ju Bae International Journal of Molecular Sciences.2024; 25(15): 8362. CrossRef
Chitinase-3 like-protein-1, a prognostic biomarker in patients with hepatocellular carcinoma and concomitant myosteatosis Chiyu He, Zhihang Hu, Zuyuan Lin, Hao Chen, Chenghao Cao, Jinyan Chen, Xudong Yang, Huigang Li, Wei Shen, Xuyong Wei, Li Zhuang, Shusen Zheng, Xiao Xu, Di Lu BMC Cancer.2024;[Epub] CrossRef
Association of interleukin-6 with sarcopenia and its components in older adults: a systematic review and meta-analysis of cross-sectional studies Jie Ding, Guangyue Yang, Wen Sun, Yifei Li, Ning Wang, Jiening Wang, Yongfang Zhao Annals of Medicine.2024;[Epub] CrossRef
NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment Ji Young Kim, Wonseok Kang, Sera Yang, Su Hyun Park, Sang Yun Ha, Yong-Han Paik Scientific Reports.2024;[Epub] CrossRef
Textbook outcomes of hepatocellular carcinoma patients with sarcopenia: A multicenter analysis Di-Hang Wu, Cheng-Yu Liao, Dan-Feng Wang, Long Huang, Ge Li, Jiang-Zhi Chen, Liang Wang, Tian-Sheng Lin, Jian-Lin Lai, Song-Qiang Zhou, Fu-Nan Qiu, Zhi-Bo Zhang, Yan-Ling Chen, Yao-Dong Wang, Xiao-Chun Zheng, Yi-Feng Tian, Shi Chen European Journal of Surgical Oncology.2023; 49(4): 802. CrossRef
Letter regarding “Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis” Do Seon Song, U Im Chang, Jin Mo Yang Clinical and Molecular Hepatology.2023; 29(1): 165. CrossRef
Association between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma: an updated meta-analysis Yusheng Guo, Yanqiao Ren, Licheng Zhu, Lian Yang, Chuansheng Zheng Scientific Reports.2023;[Epub] CrossRef
Integrative characterisation of secreted factors involved in intercellular communication between prostate epithelial or cancer cells and fibroblasts Yunjian Wu, Kimberley C. Clark, Birunthi Niranjan, Anderly C. Chüeh, Lisa G. Horvath, Renea A. Taylor, Roger J. Daly Molecular Oncology.2023; 17(3): 469. CrossRef
Pre-Therapeutic Sarcopenia among Cancer Patients: An Up-to-Date Meta-Analysis of Prevalence and Predictive Value during Cancer Treatment Anne-Laure Couderc, Evelyne Liuu, Pascaline Boudou-Rouquette, Johanne Poisson, Maxime Frelaut, Coline Montégut, Soraya Mebarki, Romain Geiss, Zoé ap Thomas, Aurélien Noret, Monica Pierro, Capucine Baldini, Elena Paillaud, Frédéric Pamoukdjian Nutrients.2023; 15(5): 1193. CrossRef
Interaction between sarcopenia and nonalcoholic fatty liver disease Sae Kyung Joo, Won Kim Clinical and Molecular Hepatology.2023; 29(Suppl): S68. CrossRef
Review article: Putting some muscle into sarcopenia—the pathogenesis, assessment and clinical impact of muscle loss in patients with inflammatory bowel disease Stephanie L. Gold, Maitreyi Raman, Bruce E. Sands, Ryan Ungaro, João Sabino Alimentary Pharmacology & Therapeutics.2023; 57(11): 1216. CrossRef
Interleukin-6: A New Marker of Advanced-Sarcopenic HCC Cirrhotic Patients Andrea Dalbeni, Leonardo Antonio Natola, Marta Garbin, Mirko Zoncapè, Filippo Cattazzo, Anna Mantovani, Antonio Vella, Stefania Canè, Jasmin Kassem, Michele Bevilacqua, Simone Conci, Tommaso Campagnaro, Andrea Ruzzenente, Alessandra Auriemma, Alessandro D Cancers.2023; 15(9): 2406. CrossRef
Prevalence of sarcopenia among patients with hepatocellular carcinoma: A systematic review and meta‑analysis Jiye Liu, Hanyong Luo, Letian Huang, Jiahe Wang Oncology Letters.2023;[Epub] CrossRef
Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review Amirhossein Ahmadi Hekmatikar, André Nelson, Aaron Petersen BMC Cancer.2023;[Epub] CrossRef
Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis Shanshan Guo, Yonghao Feng, Xiaopeng Zhu, Xinyi Zhang, Hui Wang, Ruwen Wang, Qiongyue Zhang, Yiming Li, Yan Ren, Xin Gao, Hua Bian, Tiemin Liu, Huanqing Gao, Xingxing Kong Nature Communications.2023;[Epub] CrossRef
Impact of sarcopenia and sarcopenic obesity on survival in patients with primary liver cancer: a systematic review and meta-analysis Xuanmei Li, Xue Huang, Lifu Lei, Shiwen Tong Frontiers in Nutrition.2023;[Epub] CrossRef
Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture Renwang Sheng, Mumin Cao, Mingyuan Song, Mingyue Wang, Yuanwei Zhang, Liu Shi, Tian Xie, Yingjuan Li, Jinyu Wang, Yunfeng Rui Journal of Orthopaedic Translation.2023; 43: 36. CrossRef
Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions Abhilash Perisetti, Hemant Goyal, Rachana Yendala, Saurabh Chandan, Benjamin Tharian, Ragesh Babu Thandassery World Journal of Gastroenterology.2022; 28(4): 432. CrossRef
Interleukin-6 Induced Proliferation Is Attenuated by Transforming Growth Factor-β-Induced Signaling in Human Hepatocellular Carcinoma Cells Abhilasha Srivastava, Harshita Sharma, Simran Khanna, Tejasvini Sadhu Balasundaram, Shibasish Chowdhury, Rajdeep Chowdhury, Sudeshna Mukherjee Frontiers in Oncology.2022;[Epub] CrossRef
Leaky gut-derived tumor necrosis factor-α causes sarcopenia in patients with liver cirrhosis Takumi Kawaguchi, Takuji Torimura Clinical and Molecular Hepatology.2022; 28(2): 177. CrossRef
Association between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis Ji Won Han, Da In Kim, Hee Chul Nam, U Im Chang, Jin Mo Yang, Do Seon Song Clinical and Molecular Hepatology.2022; 28(2): 219. CrossRef
Prognostic significance of cachexia index in patients with advanced hepatocellular carcinoma treated with systemic chemotherapy Myung Ji Goh, Wonseok Kang, Woo Kyoung Jeong, Dong Hyun Sinn, Geum-Youn Gwak, Yong-Han Paik, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik Scientific Reports.2022;[Epub] CrossRef
A Review of Sarcopenia Pathophysiology, Diagnosis, Treatment and Future Direction Myung-Rae Cho, Sungho Lee, Suk-Kyoon Song Journal of Korean Medical Science.2022;[Epub] CrossRef
Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma Meenakshi Vachher, Savita Bansal, Bhupender Kumar, Sandeep Yadav, Taruna Arora, Nalini Moza Wali, Archana Burman Journal of Cellular Biochemistry.2022; 123(10): 1553. CrossRef
Clinical Usefulness of Monitoring Muscle Volume during Atezolizumab Plus Bevacizumab Therapy in Patients with Unresectable Hepatocellular Carcinoma Hiroaki Matsumoto, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Hayakawa, Yutaka Yasui, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Taisei Keitoku, Tsubasa Nobusawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chia Cancers.2022; 14(14): 3551. CrossRef
CT-based skeletal muscle loss for predicting poor survival in patients with hepatocellular carcinoma experiencing curative hepatectomy plus adjuvant transarterial chemoembolization: a preliminary retrospective study Siwei Yang, Zhiyuan Zhang, Tianhao Su, Jianan Yu, Shasha Cao, Haochen Wang, Long Jin European Journal of Medical Research.2022;[Epub] CrossRef
Computed tomography-measured body composition and survival in rectal cancer patients: a Swedish cohort study Angeliki Kotti, Annica Holmqvist, Mischa Woisetschläger, Xiao-Feng Sun Cancer & Metabolism.2022;[Epub] CrossRef
Impacts of muscle mass dynamics on prognosis of outpatients with cirrhosis Tae Hyung Kim, Young Kul Jung, Hyung Joon Yim, Joo Won Baik, Sun Young Yim, Young-Sun Lee, Yeon Seok Seo, Ji Hoon Kim, Jong Eun Yeon, Kwan Soo Byun Clinical and Molecular Hepatology.2022; 28(4): 876. CrossRef
What Is the Role of Body Composition Assessment in HCC Management? Pompilia Radu, Maryam Ebadi, Aldo J. Montano-Loza, Jean Francois Dufour Cancers.2022; 14(21): 5290. CrossRef
The effect of sarcopenia and serum myokines on prognosis and survival in cirrhotic patients: a multicenter cross-sectional study Salih Boga, Abdullah Emre Yildirim, Enver Ucbilek, Ali Riza Koksal, Sevil Tokdemir Sisman, Ibrahim Durak, Ilker Sen, Beril Dogu, Erdinc Serin, Ayse Bolat Ucbilek, Makbule Ozge Yildirim, Sukru Mehmet Erturk, Huseyin Alkim, Canan Alkim European Journal of Gastroenterology & Hepatology.2022; 34(12): 1261. CrossRef
Association between sarcopenia and prognosis of hepatocellular carcinoma: A systematic review and meta-analysis Chuan Jiang, Yanyan Wang, Wei Fu, Guozhuan Zhang, Xiaoshan Feng, Xing Wang, Fang Wang, Le Zhang, Yang Deng Frontiers in Nutrition.2022;[Epub] CrossRef
Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans Grigorios Panagiotou, Wael Ghaly, Jagriti Upadhyay, Kalliopi Pazaitou-Panayiotou, Christos S Mantzoros The Journal of Clinical Endocrinology & Metabolism.2021; 106(5): e2137. CrossRef
Treatment efficacy by hepatic arterial infusion chemotherapy vs. sorafenib after liver-directed concurrent chemoradiotherapy for advanced hepatocellular carcinoma Sojung Han, Hye Jin Choi, Seung-Hoon Beom, Hye Rim Kim, Hyein Lee, Jae Seung Lee, Hye Won Lee, Jun Yong Park, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jinsil Seong, Jong Yun Won, Beom Kyung Kim Journal of Cancer Research and Clinical Oncology.2021; 147(10): 3123. CrossRef
High Visceral Adipose Tissue Density Correlates With Unfavorable Outcomes in Patients With Intermediate-Stage Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Qiang Li, Lei Zhang, Zhong-Heng Hou, Dong-Xu Zhao, Jian-Bin Li, Shuai Zhang, Yu Yin, Cai-Fang Ni, Tao Chen Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Serum concentrations of oxytocin, DHEA and follistatin are associated with osteoporosis or sarcopenia in community-dwelling postmenopausal women Yanping Du, Cuidi Xu, Hongli Shi, Xin Jiang, Wenjing Tang, Xiaoqing Wu, Minmin Chen, Huilin Li, Xuemei Zhang, Qun Cheng BMC Geriatrics.2021;[Epub] CrossRef
A Multifactorial Approach for Sarcopenia Assessment: A Literature Review Rashmi Supriya, Kumar Purnendu Singh, Yang Gao, Feifei Li, Frédéric Dutheil, Julien S. Baker Biology.2021; 10(12): 1354. CrossRef
Irisin in Liver Cirrhosis Michał Kukla, Lubomir Skladany, Tomasz Menżyk, Aleksandra Derra, Dominika Stygar, Magdalena Skonieczna, Dorota Hudy, Katarzyna Nabrdalik, Janusz Gumprecht, Wojciech Marlicz, Anastasios Koulaouzidis, Tomas Koller Journal of Clinical Medicine.2020; 9(10): 3158. CrossRef
Sarcopenia and blood myokine levels as prognostic biomarkers in patients with liver cirrhosis or hepatocellular carcinoma Sooyeon Oh, Jooho Lee Clinical and Molecular Hepatology.2020; 26(4): 476. CrossRef
Background/Aims Glypican-3 (GPC3) protein is highly expressed in hepatocellular carcinoma (HCC) tissue. It has been suggested as a diagnostic biomarker, but its inconsistent performance means that it requires further assessment. We therefore investigated the diagnostic value of the plasma GPC3 level compared to the alpha-fetoprotein (AFP) level as a diagnostic biomarker of HCC.
Methods We enrolled 157 consecutive patients with newly diagnosed HCC and 156 patients with liver cirrhosis (LC) as the control group. GPC3 plasma levels were measured using two commercially available enzyme-linked immunosorbent assays (ELISAs, named as Assay 1 and 2), and AFP levels were measured using an enzyme-linked chemiluminescent immunoassay. The diagnostic accuracy was analyzed using the receiver operating characteristics (ROC) curve.
Results Plasma GPC3 levels in HCC patients were very low (0–3.09 ng/mL) in Assay 1, while only 3 of the 157 patients (1.9%) showed detectable GPC3 levels in Assay 2. The median GPC3 level was not significantly elevated in the HCC group (0.80 ng/mL) compared with the LC group (0.60 ng/mL). The area under the ROC curve (AUC) for GPC3 was 0.559 in Assay 1. In contrast, the median AFP level was significantly higher in HCC (27.72 ng/mL) than in LC (4.74 ng/mL), with an AUC of 0.729.
Conclusions The plasma level of GPC3 is a poor diagnostic marker for HCC, being far inferior to AFP. The development of a consistent detection system for the blood level of GPC3 is warranted.
Citations
Citations to this article as recorded by
An ingenious electrochemical system based on naphthalenediimide derivatives for ultrasensitive immunosensing of alpha-fetoprotein Ling-Yu Zhao, Guo-Dong Shen, De-He Wang, Wei Zhang, Huai-Qing Zhao, Rong-Na Ma, Huai-Sheng Wang Talanta.2025; 283: 127135. CrossRef
A dual-signal output electrochemical aptasensor for glypican-3 ultrasensitive detection based on reduced graphene oxide-cuprous oxide nanozyme catalytic amplification strategy Guiyin Li, Huafu Feng, Xinhao Li, Shengnan Li, Jintao Liang, Zhide Zhou Bioelectrochemistry.2024; 158: 108709. CrossRef
Normal Glypican-3 Serum Levels Do Not Eliminate the Risk of Hepatocellular Carcinoma Agnieszka Lembas, Tomasz Mikuła, Magdalena Suchacz, Joanna Kozłowska, Szymon Barczak, Barbara Badura, Alicja Wiercińska-Drapało Galician Medical Journal.2024;[Epub] CrossRef
A chemiluminescence immunosensor for biomarker detection based on boronic acid-modified magnetic composite microspheres Xiuli Wang, Leyi He, Yaoxia Li, Jia Guo, Changchun Wang Journal of Materials Chemistry B.2024; 12(40): 10285. CrossRef
A fluorescence aptasensor based on GSH@GQDs and RGO for the detection of Glypican-3 Huixue Wang, Jinya Liu, Wei Chen, Jintong Na, Yong Huang, Guiyin Li Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 270: 120798. CrossRef
Clinical implications of exosome-derived noncoding RNAs in liver Zhe Wen Zhou, Wei Zheng, Zheng Xiang, Cun Si Ye, Qiao Qiao Yin, Shou Hao Wang, Cheng An Xu, Wen Hao Wu, Tian Chen Hui, Qing Qing Wu, Ling Yun Zhao, Hong Ying Pan, Ke Yang Xu Laboratory Investigation.2022; 102(5): 464. CrossRef
Label-free detection of glypican-3 using reduced graphene oxide /polyetherimide/gold nanoparticles enhanced aptamer specific sensing interface on light-addressable potentiometric sensor Guiyin Li, Bo Wang, Le Zhao, Xiaohang Shi, Guanxiong Wu, Wei Chen, Lixian Sun, Jintao Liang, Zhide Zhou Electrochimica Acta.2022; 426: 140808. CrossRef
Preparation of an electrochemical immunosensor based on a Cu/Cu2O-rGO@Au signal synergistic amplification strategy and efficient and sensitive detection of alpha-fetoprotein Min Wang, Mingzhe Jiang, Xiaochen Liao, Xiao Wang, Wenjing Lai, Pengli Li, Jiajia Li, Chenglin Hong, Yu Qi Analytical Methods.2022; 14(27): 2703. CrossRef
Elevated alpha-fetoprotein in asymptomatic adults: Clinical features, outcome, and association with body composition Sangmi Jang, Gwang Hyeon Choi, Won Chang, Eun Sun Jang, Jin-Wook Kim, Sook-Hyang Jeong, Nobuyuki Takahashi PLOS ONE.2022; 17(7): e0271407. CrossRef
Highly sensitive electrochemical aptasensor for Glypican-3 based on reduced graphene oxide-hemin nanocomposites modified on screen-printed electrode surface Guiyin Li, Huafu Feng, Xiaohang Shi, Min Chen, Jintao Liang, Zhide Zhou Bioelectrochemistry.2021; 138: 107696. CrossRef
Proteomic Profiling and Artificial Intelligence for Hepatocellular Carcinoma Translational Medicine Nurbubu Moldogazieva, Innokenty Mokhosoev, Sergey Zavadskiy, Alexander Terentiev Biomedicines.2021; 9(2): 159. CrossRef
Abdominal ultrasound and alpha-foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease Agostino Colli, Tin Nadarevic, Damir Miletic, Vanja Giljaca, Mirella Fraquelli, Davor Štimac, Giovanni Casazza Cochrane Database of Systematic Reviews.2021;[Epub] CrossRef
Experimental Validation of Novel Glypican 3 Exosomes for the Detection of Hepatocellular Carcinoma in Liver Cirrhosis Yucel Aydin, Ali Riza Koksal, Paul Thevenot, Srinivas Chava, Zahra Heidari, Dong Lin, Tyler Sandow, Krzysztof Moroz, Mansour A Parsi, John Scott, Ari Cohen, Srikanta Dash Journal of Hepatocellular Carcinoma.2021; Volume 8: 1579. CrossRef
Label-free electrochemical aptasensor based on reduced graphene oxide–hemin–chitosan nanocomposite for the determination of glypican-3 Min Chen, Haimei Li, Xueming Su, Runqiang Wu, Huafu Feng, Xiaohang Shi, Jintao Liang, Jiejing Chen, Guiyin Li New Journal of Chemistry.2021; 45(19): 8608. CrossRef
Diagnostic value of serum glypican-3 alone and in combination with AFP as an aid in the diagnosis of liver cancer Shuxia Liu, Minjie Wang, Cuiling Zheng, Qiaofeng Zhong, Yuankai Shi, Xiaohong Han Clinical Biochemistry.2020; 79: 54. CrossRef
Soluble cluster of differentiation 26/soluble dipeptidyl peptidase-4 and glypican-3 are promising serum biomarkers for the early detection of Hepatitis C virus related hepatocellular carcinoma in Egyptians Salwa H. Gomaa, Mona M. Abaza, Hoda A. Elattar, Gamal A. Amin, Doaa M. Elshahawy Arab Journal of Gastroenterology.2020; 21(4): 224. CrossRef
Blood exosomal micro ribonucleic acid profiling reveals the complexity of hepatocellular carcinoma and identifies potential biomarkers for differential diagnosis Lang-Qing Sheng, Jia-Rong Li, Hao Qin, Ling Liu, Da-Dong Zhang, Qi Zhang, Meng-Li Huang, Xiao-Li Li, Xiao-Ya Xu, Yang-Nian Wei, Zi-Shuo Chen, Hui Luo, Ji-Yang Zhang, Cheng-Hui Zhou, Hao Chen, Ze-Guo Chen, Fu-Gen Li, Nian-Feng Li World Journal of Gastrointestinal Oncology.2020; 12(10): 1195. CrossRef
Improving the Detection of Hepatocellular Carcinoma using serum AFP expression in combination with GPC3 and micro-RNA miR-122 expression Jian Li, Sun Qiyu, Tiezheng Wang, Boxun Jin, Ning Li Open Life Sciences.2019; 14(1): 53. CrossRef
Performance of Serum Glypican 3 in Diagnosis of Hepatocellular Carcinoma: A meta-analysis Dahai Xu, Chang Su, Liang Sun, Yuanyuan Gao, Youjun Li Annals of Hepatology.2019; 18(1): 58. CrossRef
Influence of Glypican-3 as Anewly Diagnostic Biomarker in Earlydetection of Hepatocellular Carcinoma among Saudi Patients Randa Mohamed MA Farag, Dujana AlAyobi, Khalid A Alsaleh, Hye-Joo Kwon, Afaf EL-Ansary, Emad Anwar Dawoud Biomedical and Pharmacology Journal.2018; 11(4): 1789. CrossRef
Role of exosomes and exosomal microRNAs in hepatocellular carcinoma: Potential in diagnosis and antitumour treatments (Review) Jing‑Hua Pan, Hong Zhou, Xiao‑Xu Zhao, Hui Ding, Wei Li, Li Qin, Yun‑Long Pan International Journal of Molecular Medicine.2018;[Epub] CrossRef
Dual signal amplification strategy of Au nanopaticles/ZnO nanorods hybridized reduced graphene nanosheet and multienzyme functionalized Au@ZnO composites for ultrasensitive electrochemical detection of tumor biomarker Xian Fang, Junfeng Liu, Jing Wang, Hong Zhao, Hongxuan Ren, Zengxi Li Biosensors and Bioelectronics.2017; 97: 218. CrossRef
First
Prev
