Clinical and Molecular Hepatology

"Body mass index"

Editorials

The other face of GWAS: Editorial on “Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease”: Hyungtai Sim, Murim Choi; Clin Mol Hepatol 2026;32(2):928-930.
Published online July 8, 2025; DOI: https://doi.org/10.3350/cmh.2025.0677

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Steatotic liver disease

Lean or Non-obese Nonalcoholic Fatty Liver Disease Patients: Are They Really Lean?: Eugene Han, Yong-ho Lee; Clin Mol Hepatol 2023;29(4):980-983.
Published online August 16, 2023; DOI: https://doi.org/10.3350/cmh.2023.0250

Citations

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Frequency and risk factors of metabolic associated fatty liver disease among medical students in Egypt
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Diagnosis and Management of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review
Basile Njei, Prince Ameyaw, Yazan Al-Ajlouni, Lea-Pearl Njei, Sarpong Boateng
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Non-alcoholic fatty liver disease in people with normal body weight
S. V. Turkina, I. A. Tyshchenko, M. N. Titarenko
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Original Articles

Steatotic liver disease

Regional prevalence of non-alcoholic fatty liver disease in Seoul and Gyeonggi-do, Korea: Eun Haeng Jeong, Dae Won Jun, Yong Kyun Cho, Young Gil Choe, Seungho Ryu, Seung Min Lee, Eun Chul Jang; Clin Mol Hepatol 2013;19(3):266-272.
Published online September 30, 2013; DOI: https://doi.org/10.3350/cmh.2013.19.3.266

Abstract
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Background/Aims

The prevalence of nonalcoholic fatty liver disease (NAFLD) in Korea has increased recently. The aim of the present study was to determine the regional differences in the prevalence and characteristics of NAFLD.

Methods

From January 2009 to December 2010, 161,891 Seoul and Gyeonggi-do residents receiving a health examination at our institution were enrolled in this cross-sectional study. After applying exclusion criteria, the data of 141,610 subjects (80,943 males, 60,667 females) were analyzed. The presence of NAFLD was established by ultrasound examination.

Results

The overall prevalence of NAFLD was 27.3% (38.3% in men, 12.6% in women). When standardized according to age, area, and sex, the prevalence of NAFLD was 25.2%. The age and area standardized prevalence of NAFLD was higher for men (34.4%) than for women (12.2%; P<0.001). The overall prevalence of NAFLD was higher in Gyeonggi-do (27.7%) than in Seoul (26.9%; P<0.001). Among the men, the prevalence of NAFLD was higher in Gyeonggi-do (39.2%) than in Seoul (37.4%; P<0.001), while for the women it was higher in Seoul (13.2%) than in Gyeonggi-do (12.0%; P<0.001).

Conclusions

The regional prevalence of NAFLD differed between Seoul and Gyeonggi-do. Further studies are needed to establish the etiology of this difference.

Citations

Citations to this article as recorded by

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Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease: Dong Min Lee , Seung Ok Lee , Byoung Sik Mun , Heok Soo Ahn , Hye Young Park* , Hye Soo Lee* , Dae Ghon Kim; Korean J Hepatol 2002;8(4):355-362.

Abstract
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Background/Aims
Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, ε2, ε3, and ε4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease. Methods: We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea. Results: The frequencies of APOE alleles in fatty liver patients were 6.5% in ε2, 85.7% in ε3 and 7.8% in ε4. The corresponding frequencies in control subjects were 4.0% in ε2, 91.0% in ε3 and 5.0% in ε4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE ε2 and ε4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE ε2 and ε4 allele frequencies. Conclusions: These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease. (Korean J Hepatol 2002;8:355-362)