Young Mi Hong, Ki Tae Yoon, Mong Cho, Dae Hwan Kang, Hyung Wook Kim, Cheol Woong Choi, Su Bum Park, Jeong Heo, Hyun Young Woo, Won Lim, SM Bakhtiar UI Islam
Clin Mol Hepatol 2016;22(2):267-271. Published online May 16, 2016
The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargement that was detected when examining his general weakness and weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated liver enzymes, normal prothrombin time percentage and high levels of tumor markers (α-fetoprotein and des-γ-carboxyprothrombin). Abdominal computed tomography showed multiple enhanced masses in the liver and multiple enlarged lymph nodes in the abdomen. A bone marrow biopsy revealed only a few normal hematopoietic cells and abundant tumor cells. Despite its rarity, bone marrow metastasis should always be suspected in HCC patients even if accompanied by cirrhosis.
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Rare Site Hepatocellular Carcinoma Metastasis
Enrique Boldo, Ana Santafe, Araceli Mayol, Rafael Lozoya, Alba Coret, Diana Escribano, Carlos Fortea, Andres Muñoz, Juan Carlos Pastor, Guillermo Pérez de Lucia, Nuria Bosch Aparicio Journal of Hepatocellular Carcinoma.2020; Volume 7: 39. CrossRef
Presumed disseminated carcinomatosis of the bone marrow in a dog Bárbara Andreia Jardim Gomes, Eilidh Gunn, Caroline Millins, Elspeth M Waugh, Gawain Hammond Veterinary Record Case Reports.2020;[Epub] CrossRef
Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4 Zhongrong Guo, Wen Chen, Guisen Dai, Yuanliang Huang International Journal of Molecular Medicine.2019;[Epub] CrossRef
Bo Kyoung Kim , Hwang Choi , Byung Wook Kim , Ji Hyen Choi , Jae Myung Park , Ji Hyen Ju , Myung Gyu Choi , Jae Kwang Kim , Chagn Suk Kang , Woo Sung Min , Chun Choo Kim , Kyu Wo
The clinical syndrome of venoocclusive disease of the liver is one of several manifestations of regimen-related toxicity that can occur after high-dose cytoreductive therapy. Hepatic dysfunction after bone marrow transplantation may result from a number of causes such as pretransplant chemoradiation, graft-versus host disease, drugs for prophylaxis of graft-versus host disease, venoocclusive disease, various infections, and infiltration of recurrent malignancy. The clinical distinction of these causes may be difficult and the treatment of each cause is also quite different. Therefore the diagnosis of veno-occlusive disease is important. Veno-occlusive disease affects zone 3 of the liver acinus and produces a syndrome of jaundice, painful hepatomegaly, and fluid retention. Veno-occlusive disease occurs in up to 50% of the patients who undergo BMT and is usually associated with a high mortality rate. In Korea, there are a few case reports on venoocclusive disease after BMT which were only confirmed by clinical symptoms. This is a first report of two cases of hepatic veno-occlusive disease after allogenic BMT, which were proven by laparoscopic liver biopsy in our country. (Korean J Hepatol 1998;4:179 - 187)
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