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"Burden of disease"

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Hepatic neoplasm

The current trends in the health burden of primary liver cancer across the globe
Peter Konyn, Aijaz Ahmed, Donghee Kim
Clin Mol Hepatol 2023;29(2):358-362.
Published online March 14, 2023
DOI: https://doi.org/10.3350/cmh.2023.0092

Citations

Citations to this article as recorded by  Crossref logo
  • Integrative genomic and transcriptomic profiling identifies HSPA5 as a central player in hepatocellular carcinoma pathogenesis
    Taimoor Riaz, Sumbal Rasheed, Muhammad Zubair
    Computational Biology and Chemistry.2026; 120: 108722.     CrossRef
  • Diagnostic Test Accuracy of Contrast‐Enhanced Ultrasound With Sonazoid for Assessment of Focal Liver Lesions: A Systematic Review and Meta‐Analysis
    Yongqing Tang, Shun‐ichi Sasaki, Joshua Hawley, Aurélie Peillon, Anders Sjöström, Adolfo Fuentes‐Alburo, Francois Tranquart
    Journal of Clinical Ultrasound.2025; 53(3): 510.     CrossRef
  • Contemporary awareness of viral hepatitis between 2012 and 2022 among Korean adults
    Donghee Kim, Won Kim, Aijaz Ahmed
    Clinical and Molecular Hepatology.2025; 31(1): e5.     CrossRef
  • Long-term outcomes and risk modifiers of metabolic dysfunction-associated steatotic liver disease between lean and non-lean populations
    Pojsakorn Danpanichkul, Kanokphong Suparan, Vitchapong Prasitsumrit, Aijaz Ahmed, Karn Wijarnpreecha, Donghee Kim
    Clinical and Molecular Hepatology.2025; 31(1): 74.     CrossRef
  • Dual-Functional Micelles for Codelivery of Sorafenib and Dehydrodiisoeugenol in Treatment of Hepatocellular Carcinoma
    Su-Yu Yang, Shu-Tong Li, Tian-Hua Li, De-Jin Ma, Jun-Jie Yu, Yang Liu, Yang Yu, Xue-Tao Li, Juan Zang, Zi-Min Yuan, Liang Kong
    ACS Applied Nano Materials.2025; 8(11): 5355.     CrossRef
  • Global burden of HBV-related liver disease: Primary liver cancer due to chronic HBV infection increased in over one-third of countries globally from 2000 to 2021
    Pojsakorn Danpanichkul, Kwanjit Duangsonk, Vincent L. Chen, Preenapun Saokhieo, Disatorn Dejvajara, Banthoon Sukphutanan, Majd B. Aboona, Chawin Lopimpisuth, Yanfang Pang, Andrew F. Ibrahim, Michael B. Fallon, Daniel Q. Huang, Donghee Kim, Amit G. Singal,
    Hepatology.2025; 82(5): 1274.     CrossRef
  • A Novel Nuclear-Localized Micropeptide, MP60, Promotes Hepatocellular Carcinoma Progression via the Epithelial-Mesenchymal Transition
    Chencheng Li, Xiu Hong, Sarra Setrerrahmane, Xiaoyi Sun, Xue Zhang, Hanmei Xu
    Cancers.2025; 17(17): 2932.     CrossRef
  • MicroRNA-372-3p impairs fatty acid metabolism in hepatocellular carcinoma cells by targeting CPT1A and ACSL4
    Chinnatam Phetkong, Thammachanok Boonto, Pannathon Thamjamrassri, Chaiyaboot Ariyachet, Pisit Tangkijvanich
    BioImpacts.2025; 15: 31075.     CrossRef
  • Social Determinants of Health in Metabolic Dysfunction‐Associated Steatotic Liver Disease and All‐Cause/Cause‐Specific Mortality
    Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, Rohit Loomba, Aijaz Ahmed
    Alimentary Pharmacology & Therapeutics.2025;[Epub]     CrossRef
  • Validation of prognostic models for predicting postsurgical outcomes in intrahepatic cholangiocarcinoma patients using a multicenter cohort
    Dong Hwan Kim, Sang Hyun Choi, Sehee Kim, Woohyung Lee, Hyung-Don Kim, Hyungjin Rhee, Eun-Suk Cho, Suk-Keu Yeom, Sumi Park, Seung Soo Lee, Mi-Suk Park
    International Journal of Surgery.2025; 111(10): 7032.     CrossRef
  • Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage: A case report and review of literature
    Xian-Shuai Kou, Fan-Fan Li, Yun Meng, Jian-Ming Zhao, Sheng-Fen Liu, Lan Zhang
    World Journal of Gastrointestinal Oncology.2024; 16(5): 2225.     CrossRef
  • Evaluation of different scoring systems for repeating Transarterial Chemoembolization in Egyptian patients with Hepatocellular Carcinoma
    Omkolsoum Alhaddad, Asmaa Gomaa, Merhan El Shamandy, Mohamed Kohla, Ahmed Edrees, Reham Ashour
    Romanian Journal of Internal Medicine.2024; 62(4): 430.     CrossRef
  • Phytochemicals and Their Nanoformulations for Targeting Hepatocellular Carcinoma: Exploring Potential and Targeting Strategies
    Safia Obaidur Rab, R. Roopashree, Farag M. A. Altalbawy, M. Ravi Kumar, Mamata Chahar, Manmeet Singh, Aziz Kubaev, Hassan Thoulfikar A. Alamir, Faraj Mohammed, Abed J. Kadhim, Merwa Alhadrawi
    Cell Biochemistry and Function.2024;[Epub]     CrossRef
  • Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma
    Ping Chen, Chengchen Yang, Ke Ren, Mingzhi Xu, Chenwei Pan, Xuewei Ye, Lanjuan Li
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Current epidemiology of chronic liver disease
    Richie Manikat, Aijaz Ahmed, Donghee Kim
    Gastroenterology Report.2023;[Epub]     CrossRef
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Hepatic neoplasm

The latest global burden of liver cancer: A past and present threat
Joo Hyun Oh, Dae Won Jun
Clin Mol Hepatol 2023;29(2):355-357.
Published online March 9, 2023
DOI: https://doi.org/10.3350/cmh.2023.0070

Citations

Citations to this article as recorded by  Crossref logo
  • Molecular and cellular secrets revealed: How umbilical cord-derived mesenchymal stem cells can target hepatocellular carcinoma
    Mohammad Sadegh Izadi, Reza Arefnezhad, Amirmasoud Asadi, Aryan Rezaee, Leila Kalantari, Farzad Nasrpour Tahouneh, Mohammad Mehdi Shadravan, Seyyed Taher Seyyed Mahmoudi, Zahra GhaniBeygi, Fatemeh Rostamnezhad, Armin Razman, Fardad Ejtehadi, Fatemeh Rezae
    Tissue and Cell.2026; 98: 103200.     CrossRef
  • Data efficient deep learning for liver and liver tumor segmentation: A comprehensive survey
    Nisha, Pramod Kumar Mishra
    Neurocomputing.2026; 663: 131937.     CrossRef
  • Exploring the potential of nanotechnology for early detection of cancer disease by microfluidic paper based analytical devices
    Maryam Sharifi, Samaneh Ghafouri, Balal Khalilzadeh, Farhad Bani, Habib Tajalli, Ibrahim Isildak
    Biosensors and Bioelectronics.2026; 294: 118243.     CrossRef
  • Gut microbiota's role in NAFLD- and HBV/HCV-related hepatocellular carcinoma: Mechanisms and therapeutic implications
    Gursimran Singh, Shazia Ansari, Satyam Yadav, Khadga Raj Aran
    Microbial Pathogenesis.2026; 211: 108273.     CrossRef
  • Uncovering the antiproliferative effects of magnolol in liver cancer: a multi-omics study integrating computational chemistry, network pharmacology, bioinformatics and in vitro experimental validations
    Yu Cai, Yutong Liu, Chang Tian, Fende Liu, Xiaojun Wang
    Molecular Diversity.2026;[Epub]     CrossRef
  • The correlation between social support and hopelessness among cancer survivors: a meta-analysis
    Lu-Ting Shen, Jian-Zeng Lan, Attiq-Ur-Rehman, Wei Li, Meng-Wei Ge, Rui Feng, Kang Zhong, Si-qi Gao, Hong-Lin Chen
    Cancer Causes & Control.2026;[Epub]     CrossRef
  • CRISPR-Cas-enabled nanocarriers in hepatocellular carcinoma: Emerging gene-editing strategies for precision liver therapy
    Ramaiyan Velmurugan, Yokesh Shanmugam, Lokeshvar Ravikumar
    Gastroenterology & Endoscopy.2026; 4(2): 86.     CrossRef
  • In vitro and in silico antimicrobial, antioxidant, and cytotoxic potentials of endophytic Alternaria alternata MPL5 from Mentha piperita
    Nisha Yadav, Himanshu Jangid, Anuprita Ray, Arun Karnwal, Gaurav Kumar, Deepak Kumar
    Discover Applied Sciences.2026;[Epub]     CrossRef
  • Comparative cytotoxic and molecular effects of deltamethrin and acetamiprid in normal and cancerous human liver cell lines
    Cansu Aydın, Selin Özkan-Kotiloğlu, Serap Yalçın-Azarkan
    Cell Biochemistry and Biophysics.2026;[Epub]     CrossRef
  • Inter‐Reader Agreement for Contrast‐Enhanced Ultrasound Liver Imaging Reporting and Data System Major Features and Final Categorization
    Cristina M. Kuon Yeng Escalante, Tania Siu Xiao, Yuko Kono, Fabio Piscaglia, Stephanie R. Wilson, Alexandra Medellin, Shuchi K. Rodgers, Virginia Planz, Aya Kamaya, David T. Fetzer, Annalisa Berzigotti, Paul S. Sidhu, Corinne E. Wessner, Kristen Bradigan,
    Journal of Ultrasound in Medicine.2025; 44(2): 349.     CrossRef
  • Curcumin-encapsulated glucan nanoparticles as an oxidative stress modulator against human hepatic cancer cells
    Tiago Roquito, Mariana Colaço, João Panão Costa, Olga Borges
    Colloids and Surfaces B: Biointerfaces.2025; 245: 114326.     CrossRef
  • Role of Locoregional Therapy on Survival After Living Donor Liver Transplantation for Hepatocellular Carcinoma--Experience from a High-volume Center
    Vibha Varma, Phani K. Nekarakanti, Shaleen Agarwal, Rajesh Dey, Subash Gupta
    Journal of Clinical and Experimental Hepatology.2025; 15(3): 102490.     CrossRef
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    Meltem Okan, Zeynep Çağlayan Arslan, Firdevs Aydın, Demet Asil, Haluk Külah
    Microchemical Journal.2025; 208: 112547.     CrossRef
  • Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer
    Md. Shimul Bhuia, Raihan Chowdhury, Meher Afroz, Md. Showkot Akbor, Md. Sakib Al Hasan, Jannatul Ferdous, Rubel Hasan, Marcus Vinícius Oliveira Barros de Alencar, Mohammad S. Mubarak, Muhammad Torequl Islam
    Chemistry & Biodiversity.2025;[Epub]     CrossRef
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    Expert Opinion on Therapeutic Targets.2025; 29(1-2): 59.     CrossRef
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    Carla Caddeo, Ilaria Nigro, Lucia Chiummiento, Maria Funicello, Paolo Lupattelli, Alessandro Santarsiere, Xavier Fernàndez-Busquets, Donatella Valenti, Emanuele Rosa, Rocchina Miglionico, Maria Francesca Armentano, Antonio Vassallo
    Journal of Drug Delivery Science and Technology.2025; 106: 106739.     CrossRef
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    Edward J Jacobs, Boris Rubinsky, Rafael V Davalos
    Radiology and Oncology.2025; 59(1): 1.     CrossRef
  • Mechanisms of hepatocellular carcinoma and cirrhosis development in concurrent steatotic liver disease and chronic hepatitis B
    Saisai Zhang, Lung-Yi Mak, Man-Fung Yuen, Wai-Kay Seto
    Clinical and Molecular Hepatology.2025; 31(Suppl): S182.     CrossRef
  • Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells
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    Journal of Hepatocellular Carcinoma.2025; Volume 12: 597.     CrossRef
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    Jingze Li, Yupeng Niu, Junwu Du, Jiani Wu, Weichen Guo, Yujie Wang, Jian Wang, Jiong Mu
    Frontiers in Cell and Developmental Biology.2025;[Epub]     CrossRef
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    Hua Wei, Jiaxin Peng
    International Journal of Molecular Sciences.2025; 26(6): 2779.     CrossRef
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    Dipanjan Ghosh, Aharna Guin, Aryan Kumar, Amlan Das, Santanu Paul
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2025; 1880(3): 189318.     CrossRef
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    Wen-Ying Zhou, Xiao-Xiao Zheng, Yang-Mei Ou, Yang-Lin Ou, Hong-Yu Jang, Yu-Xin Peng, Yi-Yi Wang, Bi-Qing Zhao, Li Li
    Phytochemistry Letters.2025; 67: 102957.     CrossRef
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    Marco Dioguardi Burgio, Roberto Cannella, Federica Vernuccio, Maxime Ronot, Valérie Vilgrain
    Hepatoma Research.2025;[Epub]     CrossRef
  • Effectiveness of herbal medicine for liver cancer treatment as revealed by a bibliometric and visualization analysis
    Yusha Shi, Juwei Wang, Yahui Zhang, Kai Wu, Yibo Zhu, Kaiwen Yan, Qin Ouyang
    Frontiers in Oncology.2025;[Epub]     CrossRef
  • Caracterización de la enfermedad hepática crónica, cirrosis y progresión a carcinoma hepatocelular en una entidad promotora de salud en Colombia: estudio retrospectivo de diez años
    Joshua Kock-Sierra, Juan Felipe Betancur-Pulgarín, Jhon Edwar Bolaños-López, Luz Eugenia Pérez-Jaramillo, Carlos José Bello-Gándara, Farley Johanna González-Patiño, José David Sanabria-Vanegas, José David Manga-Peña, Carlos Andrés Badillo-Blanco
    Hepatología.2025; 6(2): 107.     CrossRef
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    Keyang Xu, Qibiao Wu, Zhao Lingyun, Romario Nguyen, Fatema Safri, William Yang, Yikun Xu, Yun Ye, Hiu Yee Kwan, Qiang Wang, Xiuming Liang, Muhammad J.A. Shiddiky, Majid E. Warkiani, Jacob George, Liang Qiao, Jianfeng Bao
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  • Co-embedding of curcumin and gold nanoparticles with ZIF-8 nanoparticles for the treatment of liver cancer and its impact on metabolomics
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    European Journal of Pharmaceutics and Biopharmaceutics.2025; 214: 114773.     CrossRef
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    Diagnostics.2025; 15(13): 1655.     CrossRef
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    Biochemical Pharmacology.2025; 241: 117157.     CrossRef
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    International Journal of Thermal Sciences.2025; 218: 110140.     CrossRef
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    Cureus.2025;[Epub]     CrossRef
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    IEEE Access.2025; 13: 131549.     CrossRef
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    Frontiers in Oncology.2025;[Epub]     CrossRef
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    Journal of Hepatocellular Carcinoma.2025; Volume 12: 2907.     CrossRef
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    The American Journal of Pathology.2024; 194(7): 1230.     CrossRef
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    Reviews in Medical Virology.2024;[Epub]     CrossRef
  • Genomic ancestry and cancer among Latin Americans
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    Clinical and Translational Oncology.2024; 26(8): 1856.     CrossRef
  • The Deterioration of Sarcopenia Post-Transarterial Radioembolization with Holmium-166 Serves as a Predictor for Disease Progression at 3 Months in Patients with Advanced Hepatocellular Carcinoma: A Pilot Study
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    Journal of Personalized Medicine.2024; 14(5): 511.     CrossRef
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    International Journal of Nanomedicine.2024; Volume 19: 4465.     CrossRef
  • Arsenic trioxide augments immunogenic cell death and induces cGAS-STING-IFN pathway activation in hepatocellular carcinoma
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Steatotic liver disease

The growing burden of non-alcoholic fatty liver disease on mortality
Ju-Yeon Cho, Won Sohn
Clin Mol Hepatol 2023;29(2):374-376.
Published online March 6, 2023
DOI: https://doi.org/10.3350/cmh.2023.0084

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Special topic: Alcoholic liver diseases
The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC)

Alcohol-related liver disease

Global and regional impacts of alcohol use on public health: Emphasis on alcohol policies
Seung Ha Park, Dong Joon Kim
Clin Mol Hepatol 2020;26(4):652-661.
Published online October 1, 2020
DOI: https://doi.org/10.3350/cmh.2020.0160
Alcohol is a well-known risk factor for premature morbidity and mortality. The per capita alcohol consumption of the world’s population rose from 5.5 L in 2005 to 6.4 L in 2010 and was still at the level of 6.4 L in 2016. Alcohol-attributable deaths and disability-adjusted life years (DALYs) declined from 2000 to 2016 by 17.9% and 14.5%, respectively. However, these gains observed in the alcohol-attributable burden have proportionally not kept pace with the total health gains during the same period. In 2016, 3.0 million deaths worldwide and 132 million DALYs were attributable to alcohol, responsible for 5.3% of all deaths and 5.0% of all DALYs. These burdens are the highest in the regions of Eastern Europe and sub-Saharan Africa. The alcohol-attributable burden is particularly heavy among young adults, accounting for 7.2% of all premature mortalities. Among the disease categories to which alcohol is related, injuries, digestive diseases, and cardiovascular diseases are the leading causes of the alcohol-attributable burden. To reduce the harmful use of alcohol in a country, the ‘whole of government’ and ‘whole of society’ approaches are required with the implementation of evidence-based alcohol control policies, the pursuit of public health priorities, and the adoption of appropriate policies over a long period of time. In this review, we summarize previous efforts to investigate the alcohol-attributable disease burden and the best ways to protect against harmful use of alcohol and promote health.

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Artificial intelligence, epidemiology, methodology, or others

Cost-of-illness studies: concepts, scopes, and methods
Changik Jo
Clin Mol Hepatol 2014;20(4):327-337.
Published online December 24, 2014
DOI: https://doi.org/10.3350/cmh.2014.20.4.327

Liver diseases are one of the main causes of death, and their ever-increasing prevalence is threatening to cause significant damage both to individuals and society as a whole. This damage is especially serious for the economically active population in Korea. From the societal perspective, it is therefore necessary to consider the economic impacts associated with liver diseases, and identify interventions that can reduce the burden of these diseases. The cost-of-illness study is considered to be an essential evaluation technique in health care. By measuring and comparing the economic burdens of diseases to society, such studies can help health-care decision-makers to set up and prioritize health-care policies and interventions. Using economic theories, this paper introduces various study methods that are generally applicable to most disease cases for estimating the costs of illness associated with mortality, morbidity, disability, and other disease characteristics. It also presents concepts and scopes of costs along with different cost categories from different research perspectives in cost estimations. By discussing the epidemiological and economic grounds of the cost-of-illness study, the reported results represent useful information about several evaluation techniques at an advanced level, such as cost-benefit analysis, cost-effectiveness analysis, and cost-utility analysis.

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