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Влияние неалкогольной жировой болезни печени на течение беременности и неонатальные исходы: обзор литературы
Виталий Анатольевич Резник, Юрий Павлович Успенский, Полина Юрьевна Бухмирова, Александр Александрович Гнутов, Виталий Антонович Добренко University therapeutic journal.2025; 7(3): 7. CrossRef
Adverse pregnancy outcomes as a risk factor for new-onset metabolic dysfunction-associated steatotic liver disease in postpartum women: A nationwide study Young Mi Jung, Seung Mi Lee, Wonyoung Wi, Min-Jeong Oh, Joong Shin Park, Geum Joon Cho, Won Kim JHEP Reports.2024; 6(4): 101033. CrossRef
Metabolic dysfunction-associated fatty liver disease as a risk factor for adverse outcomes in subsequent pregnancy: a nationwide cohort study Seung Mi Lee, Geum Joon Cho, Won Young Wi, Errol R. Norwitz, Bo Kyung Koo, Jeesun Lee, Young Mi Jung, Soo Heon Kwak, Chan-Wook Park, Jong Kwan Jun, Sae Kyung Joo, Min-Jeong Oh, Won Kim, Joong Shin Park Hepatology International.2023; 17(2): 367. CrossRef
Nonalcoholic liver disease: Epidemiology, risk factors, natural history, and management strategies George Agyapong, Farzaneh Dashti, Bubu A. Banini Annals of the New York Academy of Sciences.2023; 1526(1): 16. CrossRef
Case Report:Pregnancy and birth in a mild phenotype of Alström syndrome Luca Marozio, Francesca Dassie, Gianluca Bertschy, Emilie M. Canuto, Gabriella Milan, Stefano Cosma, Pietro Maffei, Chiara Benedetto Frontiers in Genetics.2022;[Epub] CrossRef
Background/Aims Maternal and fetal outcomes in pregnant patients with Non-alcoholic fatty liver disease (NAFLD) have been largely unexplored. To determine the level of evidence associated with maternal and fetal outcomes in pregnant women with NAFLD.
Methods We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).
Results Twenty-two studies, with 13,641 female NAFLD patients were reviewed. The results highlight that NAFLD patients had a statistically significant increased likelihood of baseline diabetes mellitus (OR, 6.00; 95% CI, 2.21–16.31; P<0.001; n=7), baseline Hypertension (OR, 3.75; 95% CI, 2.13–6.59; P<0.001; n=4), gestational hypertension (OR, 1.83; 95% CI, 1.03–3.26; P=0.041; n=2), and pre-eclampsia (OR, 2.43; 95% CI, 1.46–4.04; P=0.001; n=3). The odds for a past and current history of gestational diabetes mellitus were OR, 3.78; 95% CI, 2.21–6.44; P<0.001; n=5 and OR, 3.23; 95% CI, 1.97– 5.31; P<0.001; n=6, respectively. As for fetal outcomes, pregnant NAFLD patients were significantly more likely to have a premature birth (OR, 2.02; 95% CI, 1.44–2.85; P<0.001; n=4), large for gestational age birth (OR, 2.01; 95% CI, 1.72–2.37; P<0.001; n=2) or a history of prior miscarriage or abortion (OR, 1.15; 95% CI, 1.02–1.30; P=0.02; n=2). Egger’s regression revealed no evidence of publication bias (P>0.05).
Conclusions This meta-analysis provides pooled evidence that NAFLD is associated with a substantial increase in maternal diabetic and hypertensive complications and multiple adverse fetal outcomes. This data is important for clinicians managing these patients before, during and after pregnancy.
Citations
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