From Metabolites to Chromatin: ACSS2-Driven Acetyl-CoA Fuels H3K27ac Chromatin Remodeling in HBV-Associated HCC

Hyeong-Jin Cho; Sung-Gyoo Park

doi:10.3350/cmh.2026.0114

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From Metabolites to Chromatin: ACSS2-Driven Acetyl-CoA Fuels H3K27ac Chromatin Remodeling in HBV-Associated HCC

Hyeong-Jin Cho^1,2, Sung-Gyoo Park^1,2

DOI: https://doi.org/10.3350/cmh.2026.0114 [Accepted]

Published online: February 2, 2026

¹College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 08826, Republic of Korea
²Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea

Corresponding author: Sung-Gyoo Park,
Email: riceo2@snu.ac.kr

Received: 23 January 2026 • Accepted: 24 January 2026

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Keywords: Hepatitis B virus, Hepatocellular carcinoma, epigenetic, ACSS2, Acetyl-CoA

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From Metabolites to Chromatin: ACSS2-Driven Acetyl-CoA Fuels H3K27ac Chromatin Remodeling in HBV-Associated HCC

DOI: https://doi.org/10.3350/cmh.2026.0114

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