Korean J Hepatol > Volume 6(4); 2000 > Article
The Korean Journal of Hepatology 2000;6(4): 448-455.
원저 / 만성 바이러스성 간염에서 수상세포 , HLA-DR 및 CD8+림프구의 역할 : 면역조직화학적 연구 ( The Role of Dendritic Cell , HLA-DR and CD8+ Presenting Lymphocytes in Chronic Viral Hepatitis : An Immunohistochemical Study )
The Role of Dendritic Cell , HLA-DR and CD8+ Presenting Lymphocytes in Chronic Viral Hepatitis : An Immunohistochemical Study
Sang Wook Choi,Don Hyun Jo,Sung Soo Kim,Jin Mo Yang,Byung Min An,Nam Ik Han,Chang Don Lee,Gyu Won Jung,Hee Sik Sun
Department of Internal Medicine, Catholic University College of Medicine, Seoul, Korea
ABSTRACT
Backgrounds
/Aims: This study focuses on the pathogenesis of inflammatory reaction and cell necrosis in patients with chronic viral hepatitis and examines the possible effects of follicular dendritic cells, HLA-DR and CD8+ presenting lymphocytes by analyzing their expression and the histological activity index (HAI) in liver tissues. Methods: Liver biopsy specimens were obtained from 59 patients with chronic hepatitis B and from 26 patients with chronic hepatitis C. The expressions of dendritic cells, HLA-DR and CD8+ presenting lymphocytes were determined by immunohistochemical stain. Results: The incidence of lymphoid follicle and/or lymphoid aggregates in portal tracts of the liver was higher in chronic hepatitis C than it was in chronic hepatitis B (84.6% vs. 15.3%, p=0.000). Follicular dendritic cells were exclusively expressed within lymphoid follicles and/or lymphocyte aggregates in portal areas. HLA-DR restricted cells were mainly observed in portal and periportal areas as well as in the area of piecemeal necrosis. CD8+ lymphocytes were diffusely expressed in portal and periportal areas and within intralobular parenchymal sinusoids. The expression of dendritic cell and HLA-DR was more frequently observed in moderate chronic hepatitis than in mild chronic hepatitis. While that of CD8+ lymphocyte expression was more frequent in severe chronic hepatitis with a high HAI score. Conclusions: The follicular dendritic cells may trap viral antigens in intraportal lymphoid follicle and present them to HLA-DR and CD8+ presenting lymphocytes. It is suggested that the associated expression of dendritic cells, HLA-DR and CD8+ presenting lymphocytes in liver tissues may play one of the biological role in immune injury in chronic viral hepatitis.
KeyWords: Chronic viral hepatitis, HLA-DR, Dendritic cell, CD8+ lymphocyte, Immunohistochemical stain
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