Hepatocellular carcinoma(HCC) usually spreads to lung, regional lymph node, bone and the other organs by hematogenous, lymphatic route and direct extention at the advanced stage. Extrahepatic metastases from small HCC are, however, rare events. The frequent involving bony metastases are spine, rib and long bone. These are rare in cranial bone. Therefore, a case of small HCC diagnosed by first manifestation of cranial bone metastasis is very rare. We report a case of cranial bone metastasis with left eyelid ptosis from small HCC and review the literature pertaining to this condition.(Korean J Hepatol 2001;7:320-324)
