The Clinical Meaning of the Emergence of Viral Breakthrough during Lamivudine Treatment in Patients with Hepatitis B Virus Related Chronic Liver Disease

Korean J Hepatol > Volume 10(2); 2004 > Article

The Korean Journal of Hepatology 2004;10(2): 108-116.

The Clinical Meaning of the Emergence of Viral Breakthrough during Lamivudine Treatment in Patients with Hepatitis B Virus Related Chronic Liver Disease

Chan Bog Park , Hyun Jeung Lim , Byung Cheol Yun , Sang Uk Lee , Byung Hoon Han

Department of Internal Medicine, Kosin University College of Medicine

ABSTRACT

Background/Aims
Viral breakthrough has been considered a major limitation of lamivudine in the treatment of hepatitis B virus related chronic liver disease. Its clinical meaning has not been thoroughly assessed. Methods: 64 patients who showed viral breakthrough during lamivudine treatment were retrospectively reviewed. We evaluated the rate of HBeAg seroconversion and hepatic decompensation after viral breakthrough. Results: After viral breakthrough, serum alanine transaminase (ALT) elevation more than 1.2×upper limit of normal (ULN) was noticed in 40 patients (62.5%). Acute flare (serum ALT elevation >×5 ULN, or serum bilirubin >3 ㎎/dL) occured in 15 patients (23.4%). During the period of follow up (15.0 9.7 months; range, 0-31 months) since viral breakthrough, decreased serum HBV-DNA level to below the detection limit and serum ALT normalization was seen in 15 patients (23.4%). HBeAg seroconversion was noticed in 7 (13.7%) of a total of 51 HBeAg positive patients at base line; in 4 (15.4%) of 26 patients with non-hepatic failure (chronic hepatitis or Child-Pugh class A liver cirrhosis) at base line; and in 2 (40.0%) of 5 patients with non-hepatic failure at base line and acute flare after viral breakthrough. During this period, terminal hepatic decompensation (Child-Pugh class C) or death was noticed in 9 (90.0%) of 10 patients who had hepatic decompensation (Child-Pugh class B or C) at baseline and acute flare after viral breakthrough. Conclusions: Acute flare after viral breakthrough seemed to continue during HBeAg seroconversion and rarely developed into terminal hepatic decompensation or death in patients with non-hepatic decompensation at baseline. Its incidence is not only high but lethal to most patients with hepatic decompensation at baseline. (Korean J Hepatol 2004;10:108-116)

KeyWords: Hepatitis B/Chronic, Lamivudine, Breakthrough