Korean J Hepatol > Volume 10(2); 2004 > Article
The Korean Journal of Hepatology 2004;10(2): 142-147.
A Case of Combined Hepatocellular-Cholangiocarcinoma with Sarcomatous Transformation and Second Primary Colon Cancer
Jae Hi Kim, M.D., Yong Gu Lee, M.D., Jun Lee, M.D., Cheol Kweon Jung, M.D., Hyeong Tae Kim, M.D., Haeyoun Kang, M.D.*, Kwang Hyun Kho, M.D., Sung Pyo Hong, M.D., Seong Gyu Hwang, M.D., Pil Won Park, M.D. and Gyu Sung Rim, M.D.
Departments of Internal Medicine and Pathology*, College of Medicine, Pochon CHA University
ABSTRACT
Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reaction for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7. (Korean J Hepatol 2004;10:142-147)
KeyWords: Neoplasm/Liver/Combined hepatocellular-cholangiocarcinoma, Colon neoplasms, Second primary cancer

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