A Case of Chronic Active Hepatitis Developed in Patient with Psoriasis after Long - term Methotrexate Treatment

Korean J Hepatol > Volume 3(1); 1997 > Article

The Korean Journal of Hepatology 1997;3(1): 78-84.

증례보고 : Methotrexate 에 의한 만성 활동성 간염 1 예 ( Case Reports : A Case of Chronic Active Hepatitis Developed in Patient with Psoriasis after Long - term Methotrexate Treatment )

A Case of Chronic Active Hepatitis Developed in Patient with Psoriasis after Long - term Methotrexate Treatment

Dae Hyun Kim , Jae Hyun Jo , Min Su Keum , Seong Gon Choi , Chang Hyeong Lee , Young Oh Kweon , Sung Kook Kim , Yong Whan Choi , Joon Mo Chung

ABSTRACT

Methotrexate (MTX) has been widely used in the treatment of psoriasis and rheumatoid arthritis. But prolonged use of MTX can induce hepatic fibrosis and even cirrhosis. To date, in Korea, there have been very few reports on hepatotoxicity due to MTX, and no report on biopsy-proven chronic active hapatitis. We report one patient who developed chronic acitve hepatitis while taking long- term daily dose of MTX(10mg per day) for psoriasis for a prolonged period.

KeyWords: Methotrexate , Chronic active hepatitis , Psoriasis