Nonalcoholic steatohepatitis (NASH), one of the NAFLDs (nonalcoholic fatty liver diseases), is regarded as a hepatic manifestation of metabolic syndrome. NASH can progress to cirrhosis, and possibly to hepatic malignancy. Currently, liver biopsy is the only reliable method of assessing the presence or absence of NASH and the stage of fibrosis. The finding of steatosis with evidence of hepatocyte injury such as inflammation, ballooning, degeneration, and/or fibrosis, is generally essential for making a diagnosis of NASH. However, its diagnostic criteria have not yet been established. The pathologic findings of NASH and related diseases, and the grading system currently in use are reviewed herein. (Korean J Hepatol 2009;15:122-130)
Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway Wonhee Hur, Joon Ho Lee, Sung Woo Kim, Jung-Hee Kim, Si Hyun Bae, Minhyung Kim, Daehee Hwang, Young Seok Kim, Taesun Park, Soo-Jong Um, Byoung-Joon Song, Seung Kew Yoon The International Journal of Biochemistry & Cell Biology.2015; 64: 265. CrossRef
Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice Sung Woo Kim, Wonhee Hur, Tian Zhu Li, Young Ki Lee, Jung Eun Choi, Sung Woo Hong, Kwang-Soo Lyoo, Chan Ran You, Eun Sun Jung, Chan Kun Jung, Taesun Park, Soo-Jong Um, Seung Kew Yoon Experimental & Molecular Medicine.2014; 46(4): e92. CrossRef
Validity and reliability of the nonalcoholic fatty liver diseases activity score (NAS) in Korean NAFLD patients and its correlation with clinical factors Kyung-Hun Lee, Sang Hoon Park, Yu Jin Kim, Kyung Rim Huh, Kwang Seon Min, Sun-Young Jun, Kyoung Oh Kim, Cheol Hee Park, Taeho Hahn, Kyo-Sang Yoo, Jong Hyeok Kim, Myung-Seok Lee, Choong Kee Park The Korean Journal of Hepatology.2010; 16(1): 29. CrossRef
