Abstract
Background/Aims
Twenty-four hour urinary sodium excretion (24-h UNa) of greater than 78 mmol/day is important in the management of cirrhotic ascites. Although the random urine sodium-to-potassium ratio (UNa/K) is strongly correlated with 24-h UNa, and approximately 95% of patients with a random UNa/K greater than 1 have 24-h UNa greater than 78mmol, few data have been published on the correlation between 24-h UNa and random UNa/K. We evaluated diagnostic value of morning and afternoon random UNa/K (AM UNa/K and PM UNa/K, respectively) with 24-h UNa. Methods: A total of 42 male patients were enrolled from October 2007 to March 2008. Each patient collected 5 mL of urine twice at random times during 24-h urine collection (at 10-12 a.m. and 3-5 p.m.). ROC curve analysis was performed to evaluate the feasibility of AM and PM UNa/K for differentiating 24-h UNa greater than 78mmol/day. Results: Forty patients with a 24-h urinary creatinine of greater than 15 mg/kg were analyzed. The 24-h UNa, AM UNa/K, and PM UNa/K were 107.9±91.2mmol (mean±SD), 3.44±3.64, and 3.97±4.60, respectively. When compared with 24-h UNa greater than 78 mmol, AUROC values for AM and PM UNa/K were 0.861 (95% CI, 0.715-0.950) and 0.929 (95% CI, 0.802-0.986), respectively (P=0.0001). No difference was found between the AUROC for AM and PM UNa/K (95% CI, -0.161-0.153, P=0.113). UNa/K greater than 1.25 was sensitive and specific for prediction of 24-h UNa greater than 78 mmol. Conclusions: The results suggest that anytime random UNa/K greater than 1.25 is an accurate, cost-effective, and convenient method for replacing 24-h UNa. Large multicentered cohort studies are needed to confirm our results. (Korean J Hepatol 2010; 16:66-74)
Citations
Citations to this article as recorded by
- KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications 2026
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Remote Sensing.2021; 13(7): 1317. CrossRef - Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites
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PLOS ONE.2021; 16(6): e0253886. CrossRef - Low sodium to potassium ratio in spot urine sample is associated with progression to acute kidney injury and mortality in hospitalized patients with cirrhosis
Elayne Cristina Morais Rateke, Camila Matiollo, Emerita Quintina de Andrade Moura, Michelle Andrigueti, Claudia Maccali, Janaína Sant'Ana Fonseca, Sabine Machado Fiorenza Canova, Janaína Luz Narciso-Schiavon, Leonardo Lucca Schiavon
Digestive and Liver Disease.2021; 53(9): 1159. CrossRef - KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications
Clinical and Molecular Hepatology.2018; 24(3): 230. CrossRef - Comparative study of spot urine Na/K ratio and 24-hour urine sodium in natriuresis evaluation of cirrhotic patients with ascites
Otávio Marcos da Silva, Gabriela Bicca Thiele, Leonardo Fayad, César Lazzarotto, Esther Buzaglo Dantas-Corrêa, Leonardo de Lucca Schiavon, Janaína Luz Narciso-Schiavon
GE Jornal Português de Gastrenterologia.2014; 21(1): 15. CrossRef - Avaliação da natriurese no doente cirrótico: determinação pontual Na+/K+na urina ou doseamento de sódio na urina de 24 horas?
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GE Jornal Português de Gastrenterologia.2014; 21(1): 7. CrossRef - Can 24‐h urine sodium excretion be replaced by spot urine sodium/potassium in patients with decompensated cirrhosis?
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Liver International.2012; 32(1): 172. CrossRef
