Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis
Sena Hwang, M.D.1, Do Young Kim, M.D.1, Minju Kim, M.D.2, Young Eun Chon, M.D.1,
Hyun Jung Lee, M.D.1, Young-Nyun Park, M.D.2, Jun Yong Park, M.D.1,
Sang Hoon Ahn, M.D.1, Kwang-Hyub Han, M.D.1, Chae Yoon Chon, M.D.1
Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
Oxaliplatin-induced porto-sinusoidal vascular disease manifesting as recurrent gastroesophageal variceal hemorrhage: a case report Ruiqi Zhao, Chang Liang, Zhuoqing Zhuang, Yuan Xia, Junzhu Lu, Yan Zhang Frontiers in Medicine.2026;[Epub] CrossRef
Combined anticoagulant deficiency causing extrahepatic portal venous obstruction: A case report Arkadeep Dhali, Rick Maity, Arijit Sinha, Prithviraj Singh, Jyotirmoy Biswas, Gopal Krishna Dhali World Journal of Clinical Cases.2026;[Epub] CrossRef
Molecular Mechanisms Underlying Vascular Liver Diseases: Focus on Thrombosis Lucia Giuli, Maria Pallozzi, Giulia Venturini, Antonio Gasbarrini, Francesca Romana Ponziani, Francesco Santopaolo International Journal of Molecular Sciences.2023; 24(16): 12754. CrossRef
Diagnosis and Management of Noncirrhotic Portal Hypertension Jaclyn E. Kagihara, Daniela Goyes, Atoosa Rabiee Current Hepatology Reports.2023; 22(4): 252. CrossRef
Porto-sinusoidal vascular disorder Andrea De Gottardi, Christine Sempoux, Annalisa Berzigotti Journal of Hepatology.2022; 77(4): 1124. CrossRef
Recurrent esophagogastric variceal bleeding due to portal vein thrombosis caused by protein S deficiency Haoxiong Zhou, Jieying Xuan, Xianyi Lin, Yunwei Guo Endoscopy International Open.2018; 06(11): E1283. CrossRef
Portal vein thrombosis with protein C-S deficiency in a non-cirrhotic patient Gustavo A Rodríguez-Leal World Journal of Hepatology.2014; 6(7): 532. CrossRef
Clinical and genetic features of protein C deficiency in 23 unrelated Chinese patients Qiulan Ding, Wei Shen, Xu Ye, Yingting Wu, Xuefeng Wang, Hongli Wang Blood Cells, Molecules, and Diseases.2013; 50(1): 53. CrossRef
A Case of Portal Vein Thrombosis in Acute Necrotizing Pancreatitis Treated with Low-Molecular-Weight Heparin Jin Hee Kim, Dong Gun Lee, Su Bin Park, Hyun Jung Lee, Hong Je Kim, Sang Ho Lee, Jae Nam Lee Korean Journal of Medicine.2013; 84(1): 76. CrossRef
A Case of Portal Vein Thrombosis by Protein C and S Deficiency Completely Recanalized by Anticoagulation Therapy Bo Kyoung Choi, Soo Hyun Yang, Kang Hum Suh, Jin Ah Hwang, Moon Hyung Lee, Won Keun Si, Ji Ho Kim Chonnam Medical Journal.2011; 47(3): 185. CrossRef
