Efficacy of Repeated Arterial Infusion of Cisplatin and 5-Fluorouracil via a Percutaneously Implantable Port System in Advanced Hepatocellular Carcinoma

Korean J Hepatol > Volume 7(1); 2001 > Article

The Korean Journal of Hepatology 2001;7(1): 61-67.

원저 / 진행성 간세포암종에서 Percutaneously Implantable Port System을 통한 간동맥 내 Cisplatin과 5-Fluorouracil 복합 화학요법의 효과 ( Efficacy of Repeated Arterial Infusion of Cisplatin and 5-Fluorouracil via a Percutaneously Implantable Port System in A

Efficacy of Repeated Arterial Infusion of Cisplatin and 5-Fluorouracil via a Percutaneously Implantable Port System in Advanced Hepatocellular Carcinoma

Hee Gon Song, Han Chu Lee, Byung-Cheol Song, Young-Hwa Chung, Yung Sang Lee, Hyun Ki Yoon1 , Kyu Bo Sung1, Dong Jin Suh

Department of Internal Medicine and Diagnostic Radiology1, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea

ABSTRACT

Background/Aims
A prospective study was performed to evaluate the efficacy of low dose administration of cisplatin (CDDP) and 5-fluorouracil (5-FU) by repeated arterial infusion via a percutaneously implantable port system (PIPS) for advanced hepatocellular carcinoma (phase II trial). Methods: Ten patients with hepatocellular carcinoma belonging to TNM stage IV, but without extrahepatic spread, were enrolled. Nine patients had main portal vein thrombosis. All the patients were positive for HBsAg. Patients were repeatedly treated with an arterial infusion of CDDP and 5-FU (10 mg and 250 mg, respectively, for 5 hours on days 1-5) via a PIPS at four week intervals. The response was assessed by dynamic CT after two courses of chemotherapy. Results: Insertion of PIPS was successful in 8 of 10 patients. Two patients could not receive a second course of chemotherapy because one died of progressive hepatic failure and the other developed local infection and pseudoaneurysm formation. All the remaining 6 patients exhibited tumor progression after two courses of chemotherapy. The median survival time was 89 days (range, 59-204). The causes of death were progressive hepatic failure in one patient and uncontrolled esophageal variceal bleeding in one patient. Conclusions: Arterial infusion chemotherapy with CDDP and 5-FU via a PIPS was not an effective treatment for patients with advanced hepatocellular carcinoma.(Korean J Hepatol 2001;7:61-67)

KeyWords: Neoplasm/ Liver/Hepatocellular carcinoma, Percutaneously implantable port system, Chemotherapy