A Case of Hypothyroidism Induced by Alpha - Interferon Therapy for Chronic Hepatitis B

Korean J Hepatol > Volume 2(1); 1996 > Article

The Korean Journal of Hepatology 1996;2(1): 77-81.

증례 : 만성 B형 간염 환자에서 알파 인터페론 치료중 발병한 갑상선 기능저하증 1 예 ( Case Report : A Case of Hypothyroidism Induced by Alpha - Interferon Therapy for Chronic Hepatitis B )

A Case of Hypothyroidism Induced by Alpha - Interferon Therapy for Chronic Hepatitis B

So Young Kwon , Jong Eun Yeon , Sei Hyun Baik , Jin Ho Kim , Young Tae Baik , Kwan Soo Byun , Chang Hong Lee

ABSTRACT

Thyroid dysfunction has heen reported as a side effect of alpha-interferon(IFN) therapy. The incidence of thyroid disorders was 1.2 - 12%' duripg 1FN therapy for chronic active hepatitis. We experienced a case of hypothyroidism developed after IFN therapy in a 48 year-old man with chronic hepatitis B. Baseline thyroid function before IFN therapy was normal and thyroid auioantibodies were also negative. High tiers ol' antimicrosomal antibody and anti-thyroglobulin antibody appeared and severe hypothyroidism followed at 6 months after starting the IFN therapy.

KeyWords: Chronic hepatitis B , Alpha - interferon , Hypothyroidism