Clin Mol Hepatol > Epub ahead of print
Non-alcoholic fatty liver disease: the pathologist’s perspective
Wei-Qiang Leow1, Anthony Wing-Hung Chan2, Paulo Giovanni L. Mendoza3, Regina Lo4, Kihan Yap5, Haeryoung Kim6
1Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore
2Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China
3Pathology and Laboratory Department, Cardinal Santos Medical Center, San Juan, Philippines
4Department of Pathology and State Key Laboratory of Liver Research (HKU), The University of Hong Kong, Hong Kong, China
5Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
6Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Correspondence :  Haeryoung Kim ,
Tel: +82-2-740-8322, Fax: +82-2-765-5600, Email:
Received: October 21, 2022  Revised: November 9, 2022   Accepted: November 10, 2022
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases characterized by fatty accumulation in hepatocytes, ranging from steatosis, non-alcoholic steatohepatitis, to cirrhosis. While histopathological evaluation of liver biopsies plays a central role in the diagnosis of NAFLD, limitations such as the problem of interobserver variability still exist and active research is underway to improve the diagnostic utility of liver biopsies. In this article, we provide a comprehensive overview of the histopathological features of NAFLD, the current grading and staging systems, and discuss the present and future roles of liver biopsies in the diagnosis and prognostication of NAFLD.
KeyWords: Non-alcoholic fatty liver disease; Biopsy; Diagnosis; Prognosis; Histology

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