Review

November 7, 2024


Stem cell exosomes: new hope and future potential for relieving liver fibrosis
Lihua Li, Yongjie Liu, Kunpeng Wang, et al.
Clin Mol Hepatol. 2025;31(2):333-349.

Review

December 11, 2024


Gut microbiota-mediated gut-liver axis: a breakthrough point for understanding and treating liver cancer
Chenyang Li, Chujun Cai, Chendong Wang, et al.
Clin Mol Hepatol. 2025;31(2):350-381.

Original Article

November 29, 2024


Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017–2023
Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, et al.
Clin Mol Hepatol. 2025;31(2):382-393.

Original Article

December 3, 2024


Cost-effectiveness and return on investment of hepatitis C virus elimination in China: A modelling study
Meiyu Wu, Jing Ma, Xuehong Wang, et al.
Clin Mol Hepatol. 2025;31(2):394-408.

Original Article

December 10, 2024


GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers
Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, et al.
Clin Mol Hepatol. 2025;31(2):409-425.

Original Article

December 10, 2024


Integrated molecular characterization of sarcomatoid hepatocellular carcinoma
Rong-Qi Sun, Yu-Hang Ye, Ye Xu, et al.
Clin Mol Hepatol. 2025;31(2):426-444.

Original Article

December 23, 2024


Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation
Ester Ciociola, Tanmoy Dutta, Kavitha Sasidharan, et al.
Clin Mol Hepatol. 2025;31(2):445-459.

Original Article

December 26, 2024


Longitudinal profile of plasma pregenomic RNA in patients with chronic hepatitis B infection on long-term nucleoside analogues and its interaction with clinical parameters
Lung-Yi Mak, Mark Anderson, Michael Stec, et al.
Clin Mol Hepatol. 2025;31(2):460-473.

Original Article

December 30, 2024


Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive
Haolong Li, Song Liu, Xu Wang, et al.
Clin Mol Hepatol. 2025;31(2):474-488.

Original Article

December 30, 2024


Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma
Weifeng Zeng, Furong Liu, Yachong Liu, et al.
Clin Mol Hepatol. 2025;31(2):489-508.

Original Article

January 2, 2025


Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity
Jin Seoub Kim, Hye Seon Kim, Kwon Yong Tak, et al.
Clin Mol Hepatol. 2025;31(2):509-524.

Original Article

January 9, 2025


Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000–2021
Pojsakorn Danpanichkul, Luis Antonio Díaz, Kanokphong Suparan, et al.
Clin Mol Hepatol. 2025;31(2):525-547.

Original Article

January 9, 2025


Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C
Tom Ryu, Young Chang, Soung Won Jeong, et al.
Clin Mol Hepatol. 2025;31(2):548-562.

Original Article

January 13, 2025


Exploring methylation signatures for high de novo recurrence risk in hepatocellular carcinoma
Da-Won Kim, Jin Hyun Park, Suk Kyun Hong, et al.
Clin Mol Hepatol. 2025;31(2):563-576.


Review
2092
Stem cell exosomes: new hope and future potential for relieving liver fibrosis
Lihua Li, Yongjie Liu, Kunpeng Wang, Jinggang Mo, Zhiyong Weng, Hao Jiang, Chong Jin
Clin Mol Hepatol. 2025;31(2):333-349.   Published online November 7, 2024
View: 2294   Download: 302  Crossref: 1
2117
Gut microbiota-mediated gut-liver axis: a breakthrough point for understanding and treating liver cancer
Chenyang Li, Chujun Cai, Chendong Wang, Xiaoping Chen, Bixiang Zhang, Zhao Huang
Clin Mol Hepatol. 2025;31(2):350-381.   Published online December 11, 2024
View: 1691   Download: 222
Original Article
2109
Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017–2023
Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, George Cholankeril, Rohit Loomba, Aijaz Ahmed
Clin Mol Hepatol. 2025;31(2):382-393.   Published online November 29, 2024
View: 2620   Download: 419  Crossref: 12
2112
Cost-effectiveness and return on investment of hepatitis C virus elimination in China: A modelling study
Meiyu Wu, Jing Ma, Xuehong Wang, Sini Li, Chongqing Tan, Ouyang Xie, Andong Li, Aaron G Lim, Xiaomin Wan
Clin Mol Hepatol. 2025;31(2):394-408.   Published online December 3, 2024
View: 1323   Download: 149  Crossref: 1
2113
GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers
Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Xiao-Chen Ma, Chen-He Yi, Bao-Rui Tao, Bo Zhang, Yue Ma, Guo Zhang, Rui Zhang, Yan Geng, Jing Lin, Jin-Hong Chen
Clin Mol Hepatol. 2025;31(2):409-425.   Published online December 10, 2024
View: 1658   Download: 238  Crossref: 7
2114
Integrated molecular characterization of sarcomatoid hepatocellular carcinoma
Rong-Qi Sun, Yu-Hang Ye, Ye Xu, Bo Wang, Si-Yuan Pan, Ning Li, Long Chen, Jing-Yue Pan, Zhi-Qiang Hu, Jia Fan, Zheng-Jun Zhou, Jian Zhou, Cheng-Li Song, Shao-Lai Zhou
Clin Mol Hepatol. 2025;31(2):426-444.   Published online December 10, 2024
View: 1441   Download: 142
2122
Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation
Ester Ciociola, Tanmoy Dutta, Kavitha Sasidharan, Lohitesh Kovooru, Francesca R. Noto, Grazia Pennisi, Salvatore Petta, Angela Mirarchi, Samantha Maurotti, Bernardette Scopacasa, Luca Tirinato, Patrizio Candeloro, Marcus Henricsson, Daniel Lindén, Oveis Jamialahmadi, Arturo Pujia, Rosellina M. Mancina, Stefano Romeo
Clin Mol Hepatol. 2025;31(2):445-459.   Published online December 23, 2024
View: 2091   Download: 319  Crossref: 2
2127
Longitudinal profile of plasma pregenomic RNA in patients with chronic hepatitis B infection on long-term nucleoside analogues and its interaction with clinical parameters
Lung-Yi Mak, Mark Anderson, Michael Stec, Matthew Shing-Hin Chung, Danny Ka-Ho Wong, Rex Wan-Hin Hui, Wai-Kay Seto, Gavin Cloherty, Man-Fung Yuen
Clin Mol Hepatol. 2025;31(2):460-473.   Published online December 26, 2024
View: 968   Download: 94
2130
Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive
Haolong Li, Song Liu, Xu Wang, Xinxin Feng, Siyu Wang, Yanli Zhang, Fengchun Zhang, Li Wang, Tengda Xu, Yongzhe Li
Clin Mol Hepatol. 2025;31(2):474-488.   Published online December 30, 2024
View: 1053   Download: 126  Crossref: 3
2132
Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma
Weifeng Zeng, Furong Liu, Yachong Liu, Ze Zhang, Haofan Hu, Shangwu Ning, Hongwei Zhang, Xiaoping Chen, Zhibin Liao, Zhanguo Zhang
Clin Mol Hepatol. 2025;31(2):489-508.   Published online December 30, 2024
View: 1941   Download: 274  Crossref: 5
2134
Male preference for TERT alterations and HBV integration in young-age HBV-related HCC: implications for sex disparity
Jin Seoub Kim, Hye Seon Kim, Kwon Yong Tak, Ji Won Han, Heechul Nam, Pil Soo Sung, Sung Won Lee, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jeong Won Jang
Clin Mol Hepatol. 2025;31(2):509-524.   Published online January 2, 2025
View: 1151   Download: 105
2140
Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000–2021
Pojsakorn Danpanichkul, Luis Antonio Díaz, Kanokphong Suparan, Primrose Tothanarungroj, Supapitch Sirimangklanurak, Thanida Auttapracha, Hanna L. Blaney, Banthoon Sukphutanan, Yanfang Pang, Siwanart Kongarin, Francisco Idalsoaga, Eduardo Fuentes-López, Lorenzo Leggio, Mazen Noureddin, Trenton M. White, Alexandre Louvet, Philippe Mathurin, Rohit Loomba, Patrick S. Kamath, Jürgen Rehm, Jeffrey V. Lazarus, Karn Wijarnpreecha, Juan Pablo Arab
Clin Mol Hepatol. 2025;31(2):525-547.   Published online January 9, 2025
View: 2936   Download: 265  Crossref: 5
2141
Adverse impact of metabolic dysfunction on fibrosis regression following direct-acting antiviral therapy: A multicenter study for chronic hepatitis C
Tom Ryu, Young Chang, Soung Won Jeong, Jeong-Ju Yoo, Sae Hwan Lee, Sang Gyune Kim, Young Seok Kim, Hong Soo Kim, Seung Up Kim, Jae Young Jang
Clin Mol Hepatol. 2025;31(2):548-562.   Published online January 9, 2025
View: 846   Download: 87  Crossref: 1
2144
Exploring methylation signatures for high de novo recurrence risk in hepatocellular carcinoma
Da-Won Kim, Jin Hyun Park, Suk Kyun Hong, Min-Hyeok Jung, Ji-One Pyeon, Jin-Young Lee, Kyung-Suk Suh, Nam-Joon Yi, YoungRok Choi, Kwang-Woong Lee, Young-Joon Kim
Clin Mol Hepatol. 2025;31(2):563-576.   Published online January 13, 2025
View: 852   Download: 66
2090
Stabilizing hepatic fatty acid oxidation: Editorial on “USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination”
Myeung Gi Choi, Na Young Lee, Ja Hyun Koo
Clin Mol Hepatol. 2025;31(2):592-595.   Published online November 6, 2024
View: 895   Download: 59
2125
Vibration-controlled transient elastography in shaping the epidemiology and management of steatotic liver disease: Editorial on “Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017–2023”
Xiao-Dong Zhou, Terry Cheuk-Fung Yip, Daniel Q Huang, Mark Dhinesh Muthiah, Mazen Noureddin, Ming-Hua Zheng
Clin Mol Hepatol. 2025;31(2):620-624.   Published online December 26, 2024
View: 1228   Download: 50  Crossref: 2
Snapshot
2072
Modulation of lymphatic vessels in management of liver disease and complications
Aarti Sharma, Pinky Juneja, Shiv K Sarin, Savneet Kaur
Clin Mol Hepatol. 2025;31(2):665-668.   Published online October 17, 2024
View: 770   Download: 60  Crossref: 1
Erratum
Erratum to ‘Genomic biomarkers to predict response to atezolizumab plus bevacizumab immunotherapy in hepatocellular carcinoma: Insights from the IMbrave150 trial’ [Clin Mol Hepatol 2024;30:807-823]
Sun Young Yim, Sung Hwan Lee, Seung-Woo Baek, Bohwa Sohn, Yun Seong Jeong, Sang-Hee Kang, Kena Park, Hyewon Park, Sunyoung S. Lee, Ahmed O. Kaseb, Young Nyun Park, Sun-Hee Leem, Michael A. Curran, Ji Hoon Kim, Ju-Seog Lee
Clin Mol Hepatol. 2025;31(2):669-670.   Published online February 27, 2025
View: 679   Download: 37
Letter to the Editor
Letter to the editor on “Evolutionary changes in metabolic dysfunction-associated steatotic liver disease and risk of hepatocellular carcinoma: A nationwide cohort study”
Hai Xu, Yong Zhou, Huikun Wu
Clin Mol Hepatol. 2025;31(2):e125-e127.   Published online December 17, 2024
View: 719   Download: 20
Correspondence
Correspondence to letter to the editor on “Contemporary awareness of viral hepatitis between 2012 and 2022 among Korean adults”
Chang Hun Lee, In Hee Kim, Sook-Hyang Jeong
Clin Mol Hepatol. 2025;31(2):e149-e151.   Published online November 6, 2024
View: 661   Download: 14
Correspondence to editorial on “Bariatric surgery reduces long-term mortality in patients with metabolic dysfunction-associated steatotic liver disease and cirrhosis”
Nicholas A. Rouillard, Linda Henry, Mindie H. Nguyen
Clin Mol Hepatol. 2025;31(2):e173-e175.   Published online January 9, 2025
View: 548   Download: 24
Addressing the burden of steatotic liver disease: The role of transient elastography: Correspondence to editorial on “Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017-2023”
Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, George Cholankeril, Rohit Loomba, Aijaz Ahmed
Clin Mol Hepatol. 2025;31(2):e180-e182.   Published online February 13, 2025
View: 468   Download: 20
The burden of steatotic liver disease before and during the COVID-19 pandemic: Correspondence to editorial on “Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017-2023”
Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, George Cholankeril, Rohit Loomba, Aijaz Ahmed
Clin Mol Hepatol. 2025;31(2):e183-e185.   Published online February 17, 2025
View: 411   Download: 10  Crossref: 1
Correspondence to editorial on “GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers”
Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Jing Lin, Jin-Hong Chen
Clin Mol Hepatol. 2025;31(2):e186-e188.   Published online January 24, 2025
View: 448   Download: 33  Crossref: 1
GOLM1 and bile acid synthesis: Correspondence to editorial on “GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers”
Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Jing Lin, Jin-Hong Chen
Clin Mol Hepatol. 2025;31(2):e189-e191.   Published online February 13, 2025
View: 494   Download: 24  Crossref: 1
Correspondence to editorial on “Integrated molecular characterization of sarcomatoid hepatocellular carcinoma”
Rong-Qi Sun, Shao-Lai Zhou
Clin Mol Hepatol. 2025;31(2):e192-e193.   Published online February 26, 2025
View: 398   Download: 18
Correspondence to editorial on “Prediction of primary biliary cholangitis among health check-up population with anti-mitochondrial M2 antibody positive”
Haolong Li, Song Liu, Xu Wang, Li Wang, Tengda Xu, Yongzhe Li
Clin Mol Hepatol. 2025;31(2):e194-e196.   Published online February 24, 2025
View: 459   Download: 27
Correspondence to editorial on “Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma”
Weifeng Zeng, Furong Liu, Yachong Liu, Zhanguo Zhang
Clin Mol Hepatol. 2025;31(2):e197-e199.   Published online February 5, 2025
View: 480   Download: 25
Correspondence to editorial on “Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000-2021”
Pojsakorn Danpanichkul, Luis Antonio Diaz, Kanokphong Suparan, Karn Wijarnpreecha, Juan Pablo Arab
Clin Mol Hepatol. 2025;31(2):e200-e202.   Published online February 17, 2025
View: 548   Download: 27
Correspondence to editorial on “Exploring methylation signatures for high de novo recurrence risk in hepatocellular carcinoma”
Kwang-Woong Lee, Young-Joon Kim
Clin Mol Hepatol. 2025;31(2):e206-e207.   Published online February 17, 2025
View: 410   Download: 17
Reply to correspondence on “Current burden of steatotic liver disease and fibrosis among adults in the United States, 2017-2023”
Jeayeon Park, Su Jong Yu
Clin Mol Hepatol. 2025;31(2):e221-e223.   Published online March 4, 2025
View: 324   Download: 5
Reply to correspondence 1 on “GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers”
Yoon-su Ha, Won Kim, Seung-Jin Kim
Clin Mol Hepatol. 2025;31(2):e226-e227.   Published online February 13, 2025
View: 696   Download: 24
Reply to correspondence 2 on “GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in MASH livers”
Nahee Hwang, Sungsoon Fang
Clin Mol Hepatol. 2025;31(2):e228-e231.   Published online February 26, 2025
View: 461   Download: 19

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Print ISSN: 2287-2728
Online ISSN: 2287-285X

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The Korean Association for the Study of the Liver
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