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Review

September 27, 2021


The role of transjugular intrahepatic portosystemic shunt in patients with portal hypertension: Advantages and pitfalls
Hae Lim Lee, Sung Won Lee
Clin Mol Hepatol. 2022;28(2):121-134.

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective interventional procedure to relieve portal hypertension, which is a main mechanism for the development of complications of liver cirrhosis (LC), such as...

Review

October 22, 2021


Approaches to quantifying hepatitis B virus covalently closed circular DNA
Henrik Zhang, Thomas Tu
Clin Mol Hepatol. 2022;28(2):135-149.

Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the...

Review

November 10, 2021


MAFLD enhances clinical practice for liver disease in the Asia-Pacific region
Takumi Kawaguchi, Tsubasa Tsutsumi, Dan Nakano, et al.
Clin Mol Hepatol. 2022;28(2):150-163.

Fatty liver is now a major cause of liver disease in the Asia-Pacific region. Liver diseases in this region have distinctive characteristics. First, fatty liver is frequently observed in lean/normal-weight...

Review

December 27, 2021


Cost-effectiveness of chronic hepatitis C screening and treatment
Hye Won Lee, Hankil Lee, Beom Kyung Kim, et al.
Clin Mol Hepatol. 2022;28(2):164-173.

Hepatitis C virus (HCV) infection is the second most common cause of chronic liver disease in South Korea, with a prevalence ranging from 0.6% to 0.8%, and HCV infection incidence...

Original Article

November 28, 2021


Protective association of Klotho rs495392 gene polymorphism against hepatic steatosis in non-alcoholic fatty liver disease patients
Wen-Yue Liu, Xiaofang Zhang, Gang Li, et al.
Clin Mol Hepatol. 2022;28(2):183-195.

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers. Klotho, an enzyme encoded by the klotho (KL)...

Original Article

January 13, 2022


Prevalence trends of non-alcoholic fatty liver disease among young men in Korea: A Korean military population-based cross-sectional study
Jaejun Lee, Taeyun Kim, Hyun Yang, et al.
Clin Mol Hepatol. 2022;28(2):196-206.

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) has become a major concern in Korea since its emergence as a dominant cause of chronic liver disease. However, no study has explored its...

Original Article

November 24, 2021


Surgery versus radiofrequency ablation in patients with Child- Pugh class-A/single small (≤3 cm) hepatocellular carcinoma
Jungnam Lee, Young-Joo Jin, Seung Kak Shin, et al.
Clin Mol Hepatol. 2022;28(2):207-218.
Background/Aims: We compared the post-treatment overall survival (OS) and recurrence-free survival (RFS) between patients with Child-Turcotte-Pugh (CTP) class-A and single small (≤3 cm) hepatocellular carcinoma (HCC) treated by surgical resection...

Original Article

July 20, 2021


Association between serum tumor necrosis factor-α and sarcopenia in liver cirrhosis
Ji Won Han, Da In Kim, Hee Chul Nam, et al.
Clin Mol Hepatol. 2022;28(2):219-231.

Background/Aims: Sarcopenia is an independent prognostic factor of liver cirrhosis (LC). However, the association between LC-related systemic inflammation and sarcopenia is unclear. Methods: Sprague-Dawley rats were treated with thioacetamide (TAA) or...

Original Article

January 5, 2022


Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats
Ki Tae Yoon, Hongqun Liu, Jing Zhang, et al.
Clin Mol Hepatol. 2022;28(2):232-241.

Background/Aims: Galectin-3 plays a key pathogenic role in cardiac hypertrophy and heart failure. The present study aimed to investigate the effects of galectin-3 on cardiomyopathy – related factors and cardiac...

Original Article

February 7, 2022


Cause of death and cause-specific mortality for primary liver cancer in South Korea: A nationwide population-based study in hepatitis B virus-endemic area
Bo Hyun Kim, Dahhay Lee, Kyu-Won Jung, et al.
Clin Mol Hepatol. 2022;28(2):242-253.

Background/Aims: Primary liver cancer is one of the leading causes of cancer mortality worldwide. However, the causes of death have not been studied in detail in patients with liver cancer. Methods:...

Original Article

December 28, 2021


Tenofovir alafenamide treatment may not worsen the lipid profile of chronic hepatitis B patients: A propensity score-matched analysis
Joonho Jeong, Jung Woo Shin, Seok Won Jung, et al.
Clin Mol Hepatol. 2022;28(2):254-264.
Background/Aims: Tenofovir alafenamide (TAF) has shown less favorable effect on lipids compared to tenofovir disoproxil fumarate (TDF) in clinical trials. However, data regarding these outcomes in patients with chronic hepatitis...
Current Issue
Volume 28(2); Apr 2022

Articles in E-pub version are posted online ahead of regular printed publication.

Editorial
Association of Nonalcoholic Fatty Liver Disease with Incident Dementia Later in Life Among Elder Adults
Byoung Seok Ye
Received April 9, 2022  Accepted May 11, 2022  
View: 108   Download: 3
Original Article
Effect of moderate-to-severe hepatic steatosis on neutralising antibody response among BNT162b2 and CoronaVac recipients
Ka Shing Cheung, Lok Ka Lam, Rex Wan Hin Hui, Xianhua Mao, Ruiqi R Zhang, Kwok Hung Chan, Ivan FN Hung, Wai Kay Seto, Man Fung Yuen
Received April 18, 2022  Accepted May 6, 2022  
View: 178   Download: 15
Review Article
NAFLD versus MAFLD: Prevalence, Outcomes and Implications of a Change in Name
Cheng Han Ng, Daniel Q. Huang, Mindie H. Nguyen
Received March 13, 2022  Accepted May 16, 2022  
View: 262   Download: 38
Original Article
Reappraisal of Sepsis-3 and CLIF-SOFA or Mortality in Patients With Cirrhosis and Infection Presenting to the Emergency Department: A Multicenter Study
Ji Hyun Kim, Baek Gyu Jun, Minjong Lee, Hye Ah Lee, Tae Suk Kim, Jeong Won Heo, Da Hye Moon, Seong Hee Kang, Ki Tae Suk, Moon Young Kim, Young Don Kim, Gab Jin Cheon, Soon Koo Baik, Dong Joon Kim, Dae Hee Choi
Received June 14, 2021  Accepted May 3, 2022  
View: 116   Download: 4
Gut-derived lipopolysaccharide promotes alcoholic hepatosteatosis and subsequent hepatocellular carcinoma by stimulating neutrophil extracellular traps through TLR4
Yang Liu, Xin Zhang, Shuo Chen, Jiazhong Wang, Shuo Yu, Yiming Li, Meng Xu, Harouna Aboubacar, Junhui Li, Tao Shan, Jixin Wang, Gang Cao
Received February 10, 2019  Accepted May 1, 2022  
View: 210   Download: 29
Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in NAFLD mouse models using modified basket trial
Ju Hee Oh, Dae Won Jun, Hye Young Kim, Seung Min Lee, Eileen L. Yoon, Jungwook Hwang, Jung Hwan Park, Hanbi Lee, Wankyu Kim, Hyunsung Kim
Received January 19, 2022  Accepted April 15, 2022  
View: 196   Download: 13
Review Article
Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review
Sang Jin Kim, Jong Man Kim
Received March 1, 2022  Accepted April 15, 2022  
View: 216   Download: 13
Letter to the Editor
Clinical significance of the discrepancy between radiological findings and biochemical responses in atezolizumab plus bevacizumab for hepatocellular carcinoma
Hideki Iwamoto, Shigeo Shimose, Takashi Niizeki, Hironori Koga, Takuji Torimura
Received February 17, 2022  Accepted April 17, 2022  
View: 211   Download: 52
Review Article
Deep learning-based prediction of molecular cancer biomarkers from tissue slides: A new tool for precision oncology
Sung Hak Lee, Hyun-Jong Jang
Received December 20, 2021  Accepted April 17, 2022  
View: 183   Download: 35
Subclinical versus advanced forms of alcohol-related liver disease: need for early detection
Concepción Gómez-Medina, Luma Melo, David Martí-Aguado, Ramón Bataller
Received January 18, 2022  Accepted April 11, 2022  
View: 177   Download: 15
Original Article
Association of Nonalcoholic Fatty Liver Disease with Incident Dementia Later in Life Among Elder Adults
Seogsong Jeong, Yun Hwan Oh, Seulggie Choi, Jooyoung Chang, Sung Min Kim, Joung Sik Son, Gyeongsil Lee, Joseph C Ahn, Dong Hyeon Lee, Bo Kyung Koo, Won Kim, Sang Min Park
Received October 22, 2021  Accepted March 16, 2022  
View: 493   Download: 74
Invited Review
Old and new classes of glucose-lowering agents as treatments for non-alcoholic fatty liver disease: a narrative review
Lei Miao, Jing Xu, Giovanni Targher, Christopher D Byrne, Ming-Hua Zheng
Received January 15, 2022  Accepted March 11, 2022  
View: 621   Download: 75
Original Article
NAFLD increases Risk of Carotid Atherosclerosis and Ischemic Stroke. An Updated Meta-Analysis with 135,602 Individuals
Ansel Shao Pin Tang, Kai En Chan, Jingxuan Quek, Jieling Xiao, Phoebe Tay, Margaret Teng, Keng Siang Lee, Snow Yunni Lin, May Zin Myint, Benjamin Tan, Vijay K Sharma, Darren Jun Hao Tan, Wen Hui Lim, Apichat Kaewdech, Daniel Huang, Nicholas WS Chew, Mohammad Shadab Siddiqui, Arun J Sanyal, Mark Muthiah, Cheng Han Ng
Received December 29, 2021  Accepted March 2, 2022  
View: 950   Download: 68
Review
The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology
Youngseok Lee, Jong-Hoon Kim
Received December 13, 2021  Accepted February 25, 2022  
View: 456   Download: 44
RNA interference as a novel treatment strategy for chronic hepatitis B infection
Rex Wan-Hin Hui, Lung-Yi Mak, Wai-Kay Seto, Man-Fung Yuen
Received February 14, 2022  Accepted February 16, 2022  
View: 765   Download: 162  Citations: 2
Intrahepatic cholangiocarcinoma: tumour heterogeneity and its clinical relevance
Mina Komuta
Received September 7, 2021  Accepted January 13, 2022  
View: 810   Download: 125
Statin and aspirin for chemoprevention of hepatocellular carcinoma: Time to use or wait further?
Myung Ji Goh, Dong Hyun Sinn
Received November 21, 2021  Accepted January 8, 2022  
View: 553   Download: 45
Review Article
Imaging Diagnosis of HCC: Future directions with special emphasis on hepatobiliary MRI and contrast-enhanced ultrasound
Junghoan Park, Jeong Min Lee, Tae-Hyung Kim, Jeong Hee Yoon
Received November 17, 2021  Accepted December 21, 2021  
View: 626   Download: 72
The best predictive model for hepatocellular carcinoma in patients with chronic hepatitis B infection
Jung Hwan Yu, Soon Gu Cho, Young-Joo Jin, Jin-Woo Lee
Received August 30, 2021  Accepted November 25, 2021  
View: 745   Download: 66
Review
Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma
Pil Soo Sung
Received September 27, 2021  Accepted October 18, 2021  
DOI: https://doi.org/10.3350/cmh.2021.0308    [Epub ahead of print]
View: 4252   Download: 138  Citation: 1

Clinical and
Molecular
Hepatology

Print ISSN: 2287-2728
Online ISSN: 2287-285X

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