| 간세포암 환자에서 경간동맥 화학색전술후 발생한 허혈성 담도 합병증 ( Ischemic Bile Duct Injury as A Serious Complication Following Transarterial Chemoembolization ) |
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| Ischemic Bile Duct Injury as A Serious Complication Following Transarterial Chemoembolization |
| Sang Soo Lee, M.D., Young-Hwa Chung, M.D., Hae Kyung Kim, M.D.
Byung-Cheol Song, M.D.,Kung No Lee, M.D., Soo Hyun Yang, M.D.
Jae Chul Hwang, M.D.*, Hyun Kee Yoon, M.D.*, Eun Sil Yoo, M.D.**
Kyu Bo Sung, M.D.*, Yung Sang Lee, M.D., Sung Gyu Lee, M.D.#
and Dong Jin Suh, M.D. |
| Department of Internal Medicine, Diagnostic Radiology*, Pathology** and General Surgery# University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. |
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| ABSTRACT |
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Background/Aims
Transarterial chemoembolization (TACE) has been reported to be one of the useful palliative treatments in patients with unresectable hepatocelluar carcinoma. However, Bile duct injuries following TACE have been reported occasionally. In this study, we intended to clarify the incidence, pathogenic mechanisms and clinical implications of bile duct injuries following TACE. Methods: A total of 950 consecutive patients with hepatocellular carcinoma (HCC) were subjected. 807 patients were treated with TACE. The remaining 143 were treated with transarterial chemoinfusion (TACI) of cisplatin. Results: None of 143 HCC patients treated with TACI revealed to have any ischemic biliary injury radiologically. In contrast, out of 807 with TACE, 17 (2%) appeared to have biliary complications. Twelve out of 17 (71%) had bilomas at subcapsular area, three out of 17 (18%) had focal strictures at common hepatic duct or common bile duct with marked dilatation of intrahepatic bile ducts and two out of 17 (11%) had diffuse mild dilatation of intrahepatic bile ducts. Interestingly, two (17%) out of 12 bilomas were found at the lobe which was not embolized with Gelfoam. The median sessions of TACE to the occurrences of focal strictures tended to be longer compared with those of bilomas (median: 6 vs. 2.5; p=0.08). All three patients with focal strictures and four (33%) out of 12 patients with bilomas were associated with serious bacterial infections at presentation. Conclusions: Biloma seems to be caused by lipiodol rather than Gelfoam; focal strictures of large bile ducts by Gelfoam. It is suggested that adjustments of the amounts of lipiodol or Gelfoam and the sites or embolization may be required to reduce the ischemic biliary injuries following TACE. (Korean J Hepatol 1999;5:217－226) |
| KeyWords:
TACE, Ischemic bile duct stricture, Biloma |
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