Hepatocellular Carcinoma with Severe Hypoglycemia : Involvement of Insulin-like Growth Factor I, II  and Insulin-like Growth Factor Binding Proteins

Korean J Hepatol > Volume 5(4); 1999 > Article

The Korean Journal of Hepatology 1999;5(4): 332-337.

심한 저혈당증을 동반한 간세포암 1예 : 인슐린양 성장인자(IGF)와 인슐린양 성장인자 결합 단백질(IGFBP) 포함 ( Hepatocellular Carcinoma with Severe Hypoglycemia : Involvement of Insulin-like Growth Factor I, II and Insulin-like Growth Factor Binding Proteins

Hepatocellular Carcinoma with Severe Hypoglycemia : Involvement of Insulin-like Growth Factor I, II and Insulin-like Growth Factor Binding Proteins

Seok Joo Kim,Bo Yeong Yun,Ha Chin Choi

Department of Internal Medicine, Paik Hospital, College of Medicine, Inje University, Pusan

ABSTRACT

We report a case of hepatocellular carcinoma presented with severe hypoglycemia. Computerized tomography and ultrasonography revealed a massive bilateral tumor with portal vein thrombosis. The levels of IGF-II (113 ng/mL) and IGFBP-3 (815 ng/mL) measured in the plasma, were lower than normal range. There was strong immunoreactivity of IGF-I and IGF-II in immunohistochemical stain of tumor cells. (Korean J Hepatol 1999;5:332－337)

KeyWords: Hepatocellular carcinoma, Hypoglycemia, IGF, IGFBP