| The Clinical Usefulness of SPIO-MRI in Detection and Staging of Hepatocellular Carcinoma |
| Kwang Cheol Koh, M.D., Hong Joo Kim, M.D., Won Hyeok Choe, M.D.,
Gyung Soo Chae, M.D., Moon Seok Choi, M.D., Joon Hyoek Lee, M.D.,
Seung Woon Paik, M.D., Jong Chul Rhee, M.D. and Kyu Wan Choi, M.D. |
| Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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| ABSTRACT |
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Background/Aims
It is still unclear whether Super Paramagnetic Iron Oxide-Magnetic Resonance Imaging (SPIO-MRI) is a clinically useful imaging modality for patients with hepatocellular carcinoma (HCC). This study searched for the clinical usefulness and limitations of SPIO-MRI with respect to tumor detection capacity, false positive and negative rate, and early recurrence rate. Methods: From December 1999 to February 2001, 218 patients who were surgical candidates by 3-phase dynamic helical CT (3dHCT) were enrolled. We reviewed the medical records and radiologic findings, retrospectively, and postulated the post-operative pathologic findings and the early recurrences within 3 months as the standards for the true positive lesion. Results: The mean number of nodules detected by SPIO-MRI was significantly more numerous than that of 3dHCT (p<0.01). Modifications of treatment strategy due to the discordant findings between SPIO-MRI and 3dHCT for tumor resectability were observed in 22 (10.1%) out of 218 patients. Early recurrences were observed in 10 patients (7.8%). The false positive and negative rates of SPIO-MRI were 6.3% and 13.3%, respectively. Conclusions: We demonstrated that the tumor detection rate of SPIO-MRI was better than that of 3dHCT. Given the relatively acceptable false positive and negative rates, SPIO-MRI could be an appropriate preoperative imaging modality for patients with HCCs.(Korean J Hepatol 2002;9:17-24) |
| KeyWords:
SPIO-MRI, 3-phase dynamic helical CT, Neoplasm/Liver/Hepatocellular carcinoma |
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