Abstract
Background/Aims
The relationships between the hepatic venous pressure gradient (HVPG) and the status
of cirrhosis, complications of portal hypertension and the severity of cirrhosis are not clear. The aim of this
study was to determine the relationships between HVPG and the complications or status of cirrhosis.
Methods
The HVPG, gastroesophageal varices, Child-Pugh score, Model for End-Stage Liver Disease
(MELD) score, presence of ascites, recent bleeding history and the status of cirrhosis were assessed in a
cohort of 172 patients (156 males, 16 females) with liver cirrhosis. Results: The HVPG was 15.6±5.1 (mean±
SD) mmHg (4-33 mmHg) and was significantly higher in patients in the decompensated stage than in those
in the compensated stage (16.6±4.3 vs. 10.8±6.1 mmHg, respectively; P<0.01). HVPG was higher in bleeders
than in nonbleeders (16.9±4.5 vs. 12.8±5.3 mmHg, respectively; P<0.01), and in patients with ascites than in
those without ascites (16.4±4.1 vs. 14.5±6.2 mmHg, respectively; P<0.05). HVPG was significantly lower in
the presence of gastric varices than in their absence (14.0±3.4 vs. 16.0±5.3 mmHg, respectively; P<0.05);
however, no significant correlation was detected between HVPG and the grade of esophageal varices (P>0.05).
HVPG was significantly higher in Child’s B cirrhosis (n=87, 15.6±4.7 mmHg) and Child’s C cirrhosis (n=36,
18.4±4.7 mmHg) than in Child’s A cirrhosis (n=49, 13.7±5.1 mmHg; P<0.01). HVPG also was strongly
correlated with the MELD score (P<0.01). The time required to measure the HVPG was 11.2±6.4 min, and
only three cases of minor complication occurred during the procedure. Conclusions: HVPG was correlated
with the severity of liver cirrhosis, presence of ascites, and risk of variceal bleeding in patients with liver
cirrhosis. (Korean J Hepatol 2008;14:150-158)
Citations
Citations to this article as recorded by
- AGA Clinical Practice Update on Interventional EUS for Vascular Investigation and Therapy: Commentary
Marvin Ryou, John M. DeWitt, Koushik K. Das, Vanessa M. Shami
Clinical Gastroenterology and Hepatology.2023; 21(7): 1699. CrossRef - Application of ultrasound for the diagnosis of cirrhosis/portal hypertension
Seul Ki Han, Moon Young Kim, Seong Hee Kang, Soon Koo Baik
Journal of Medical Ultrasonics.2022; 49(3): 321. CrossRef - Usefulness of virtual touch tissue quantification for predicting the presence of esophageal varices in patients with liver cirrhosis
Teppei Matsui, Hidenari Nagai, Gou Watanabe, Naoyuki Yoshimine, Makoto Amanuma, Kojiro Kobayashi, Yuu Ogino, Takanori Mukozu, Yasushi Matsukiyo, Yasuko Daido, Noritaka Wakui, Shigeru Nakano, Mie Shinohara, Koichi Momiyama, Takehide Kudo, Kenichi Maruyama,
JGH Open.2021; 5(6): 695. CrossRef - Splenectomy with Portoazygous Disconnection for Correction of Systemic Hemodynamic Disorders in Hepatic Cirrhosis Patients with Portal Hypertension: A Prospective Single-Center Cohort Study
Dao-Bing Zeng, Liang Di, Qing-Liang Guo, Jing Ding, Xiao-Fei Zhao, Shi-Chun Lu, Quirino Lai
Canadian Journal of Gastroenterology and Hepatology.2020; 2020: 1. CrossRef - Hepatic venous pressure gradient correlates with advanced hepatic fibrosis: a retrospective review
Jonathan K. Vincent, Christopher Stark, Joseph T. Shields, Anant D. Bhave, Christopher S. Morris
Abdominal Radiology.2017; 42(11): 2609. CrossRef - Application of a standardised protocol for hepatic venous pressure gradient measurement improves quality of readings and facilitates reduction of variceal bleeding in cirrhotics
TT Tey, A Gogna, FG Irani, CW Too, HG Lo, BS Tan, KH Tay, HF Lui, PE Chang
Singapore Medical Journal.2016; 57(03): 132. CrossRef - Comparison of hepatic venous pressure gradient and endoscopic grading of esophageal varices
EunJi Lee, Yong Jae Kim, Dong Erk Goo, Seung Boo Yang, Hyun-Joo Kim, Jae Young Jang, Soung Won Jeong
World Journal of Gastroenterology.2016; 22(11): 3212. CrossRef - The Accuracy of Ultrasonography for the Evaluation of Portal Hypertension in Patients with Cirrhosis: A Systematic Review
Gaeun Kim, Youn Zoo Cho, Soon Koo Baik, Moon Young Kim, Won Ki Hong, Sang Ok Kwon
Korean Journal of Radiology.2015; 16(2): 314. CrossRef - Clinically Severe Portal Hypertension: Role of Multi-detector Row CT Features in Diagnosis
Ji Young Lee, Tae Yeob Kim, Woo Kyoung Jeong, Yongsoo Kim, Jinoo Kim, Kyoung Won Kim, Young Hwan Kim, Joo Hyun Sohn
Digestive Diseases and Sciences.2014; 59(9): 2333. CrossRef - Relationship between Tetrahydrobiopterin and Portal Hypertension in Patients with Chronic Liver Disease
Won Ki Hong, Kwang Yong Shim, Soon Koo Baik, Moon Young Kim, Mee Yon Cho, Yoon Ok Jang, Young Shik Park, Jin Han, Gaeun Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Sang Ok Kwon
Journal of Korean Medical Science.2014; 29(3): 392. CrossRef - The Risk Factors for Bleeding of Fundal Varices in Patients with Liver Cirrhosis
Eui Ju Park, Jae Young Jang, Ji Eun Lee, Soung Won Jeong, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Joo Young Cho, Hong Soo Kim, Boo Sung Kim, Yong Jae Kim
Gut and Liver.2013; 7(6): 704. CrossRef - The usefulness of non-invasive liver stiffness measurements in predicting clinically significant portal hypertension in cirrhotic patients: Korean data
Won Ki Hong, Moon Young Kim, Soon Koo Baik, Seung Yong Shin, Jung Min Kim, Yong Seok Kang, Yoo Li Lim, Young Ju Kim, Youn Zoo Cho, Hye Won Hwang, Jin Hyung Lee, Myeong Hun Chae, Hyoun A Kim, Hye Won Kang, Sang Ok Kwon
Clinical and Molecular Hepatology.2013; 19(4): 370. CrossRef - Small Bowel Abnormalities in Patients with Compensated Liver Cirrhosis
Taiki Aoyama, Shiro Oka, Hiroshi Aikata, Makoto Nakano, Ikue Watari, Noriaki Naeshiro, Shigeto Yoshida, Shinji Tanaka, Kazuaki Chayama
Digestive Diseases and Sciences.2013; 58(5): 1390. CrossRef - Relationship between the hepatic venous pressure gradient and first variceal hemorrhage in patients with cirrhosis: a multicenter retrospective study in Korea
Jin Nyoung Kim, Kyoung Min Sohn, Moon Young Kim, Ki Tae Suk, Soung Won Jeong, Ho Eun Jung, Sae Hwan Lee, Sang Gyune Kim, Jae Young Jang, Young Seok Kim, Soon Koo Baik, Hong Soo Kim, Dong Joon Kim, Boo Sung Kim
Clinical and Molecular Hepatology.2012; 18(4): 391. CrossRef - Does the Model for End-Stage Liver Disease Score Predict Transfusion Amount, Acid-Base Imbalance, Haemodynamic and Oxidative Abnormalities during Living Donor Liver Transplantation?
J Lee, MY Chung
Journal of International Medical Research.2011; 39(5): 1773. CrossRef - Hemodynamic alterations in cirrhosis and portal hypertension
Moon Young Kim, Soon Koo Baik, Samuel S. Lee
The Korean Journal of Hepatology.2010; 16(4): 347. CrossRef - Portal Hypertensive Gastropathy: Correlation with Portal Hypertension and Prognosis in Cirrhosis
Moon Young Kim, Hoon Choi, Soon Koo Baik, Chang Jin Yea, Chan Sik Won, Jong Won Byun, So Yeon Park, Yong Hwan Kwon, Jae Woo Kim, Hyun Soo Kim, Sang Ok Kwon, Young Ju Kim, Seung Hwan Cha, Sei Jin Chang
Digestive Diseases and Sciences.2010; 55(12): 3561. CrossRef - Hepatic venous pressure gradient can predict the development of hepatocellular carcinoma and hyponatremia in decompensated alcoholic cirrhosis
Moon Young Kim, Soon Koo Baik, Chang Jin Yea, Il Young Lee, Hye Jung Kim, Kyong Won Park, Hearn Kook Kim, Ki Tae Suk, Jae Woo Kim, Hyun Soo Kim, Sang Ok Kwon, Seung Hwan Cha, Young Ju Kim, Sang Baek Koh, Sei Jin Chang
European Journal of Gastroenterology & Hepatology.2009; 21(11): 1241. CrossRef - Comparison of the Model for End-stage Liver Disease and hepatic venous pressure gradient for predicting survival in patients with decompensated liver cirrhosis
Sung Hoa Lee, Seung Ha Park, Go Woon Kim, Woo Jin Lee, Won Ki Hong, Myeong Shin Ryu, Kyu Tae Park, Min Young Lee, Chan Woo Lee, Jin Ho Kim, Yong Mook Kim, Sung Jung Kim, Gwang Ho Baik, Jin Bong Kim, Dong Joon Kim
The Korean Journal of Hepatology.2009; 15(3): 350. CrossRef - The relation between hepatic venous pressure gradient and complications of liver cirrhosis
Yong-Han Paik
The Korean Journal of Hepatology.2008; 14(2): 136. CrossRef
