| Hepatocellular carcinoma with Lymphoid stroma: report of two cases |
| Hye-Jeong Choi, M.D., Joon Hyuck Choi, M.D.1 |
| Department of Pathology, Ulsan University College of Medicine, Ulsan, Korea
1Department of Pathology, Yeungnam University College of Medicine, Deagu, Korea |
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| ABSTRACT |
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We report two cases of hepatocellular carcinoma with prominent lymphocytic infiltration, which has been
described as a subtype of hepatocellular carcinoma with good prognosis. One case showed lymphoid follicles
and dense lymphocytic infiltrates within the tumor and its periphery, and the other case showed marked
lymphocytic infiltration in the cancerous tissue. Piecemeal necrosis of cancer cells and atypical reactive
changes were evident. The two cases were seronegative for hepatitis B surface antigen, antibody to hepatitis
C virus, and Epstein-Barr virus DNA. One of the cases showed Clonorchis infestation. The prognostic
significance of lymphocytic stroma in hepatocellular carcinoma requires further investigation. (Korean J
Hepatol 2008;14:394-398) |
| KeyWords:
Lymphoid stroma; Carcinoma, Hepatocellular |
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