| 간세포암종 진단에 있어서 자동화 분석기로 측정한 AFP - L3 와 PIVKA - 2 의 임상적 유용성 ( Original Articles : Clinical Implication of Automatically Analysed AFP - L3 and PIVKA - 2 in the Diagnosis of Hepatocellular Carcinoma ) |
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| Clinical Implication of Automatically Analysed AFP - L3 and PIVKA - 2 in the Diagnosis of Hepatocellular Carcinoma |
| Cheol Kim, M.D.*, Kwang Hyub Han, M.D.*, Yong Han Paik, M.D.*, Kun Hoon Song, M.D.*,
Jae Yeon Jeong, M.D.*, Jeong Youp Park, M.D.*, Young Soo Park, M.D.*, Hyun Woong Lee, M.D.*,
Tae Joo Jeon, M.D.*, Jae Yong Han, M.D.*, Kwan Sik Lee, M.D.*, Chae Yoon Chon, M.D.*,
Young Myoung Moon, M.D.*, Kyoung Rhyul Lee, M.D.† , and Hyon Suk Kim, M.D.† |
| Department of Internal Medicine* and Clinical Pathology †, Yonsei University College of Medicine, Seoul, Korea |
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| ABSTRACT |
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Background
/ Aims : Prothrombin induced by Vitamin K Antagonist-Ⅱ(PIVKA-Ⅱ)and alpha-fetoprotein(AFP)subtype reacting with Lens Culinaris Agglutinin(AFP-L3)are known as specific tumor markers for HCC. Recently a more sensitive ELA method for PIVKA-Ⅱand an automatic analyzer with Liquid Phase Binding Assay method(LBA method)for AFP-L3 have been developed. The aim of this study was to evaluate the feasibility of PIVKA-Ⅱ and AFP-L3 measured by newly developed methods as complementary tumor markers to AFP in the diagnosis of HCC. Methods : The serum concentration of AFP, PIVKA-Ⅱ, and a fraction of AFP-L3 were determined from 188 patients with HCC and 118 patients with various liver diseases including tumors of the liver. AFP was measured by EIA, PIVKA-Ⅱ by sensitive EIA, and AFP-L3 by the LBA method with LiBASys Auto-analyzer. The cutoff values for AFP, PIVKA-Ⅱ, AND AFP-L3 WERE 400ng/mL, 40 Mau/mL, AND 15%, respectively. Results : The sensitivity and specificity of serum PIVKA-Ⅱwere 69.2% and 76.5%, respectively. Sixty-two(51.2%) of 121 patients with HCC, in which AFP was less than 400ng/mL were PIVKA-Ⅱ positive. The specificity and specificity of serum AFP-L3 were 48.8% and 90.8%, respectively. When AFP-L3 was used in combination with PIVKA-Ⅱ,31(46.3%) of the 67 patients with small less than 3cm HCC were positive for at least one of these markers. Conclusion : PIVKA-Ⅱ measures by sensitive EIA may be useful for the diagnosis of HCC with low AFP level. AFP-L3 and PIVKA-Ⅱ may improve the detection rate of small HCCs less than 3cm. (Korean J Hepatol 2001;7 :467- 474) |
| KeyWords:
AFP, PIVKA- II, AFP-L3, Hepatocellular carcinoma, Tumor markers |
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