| Carcinoma with Predominant Lymphoid Stroma in Hepatobiliary System -Report of 2 Cases- |
| Hye Sook Min , Eun Shin , Ja June Jang |
| Department of Pathology, Seoul National University College of Medicine, Seoul, Korea |
|
|
|
|
| ABSTRACT |
|
|
Lymphoepithelioma-like carcinoma (LELC) is an undifferentiated carcinoma with predominant lymphocytic
infiltration, which is associated with Epstein-Barr virus (EBV) in variable proportions. We report two cases
of carcinoma with predominant lymphoid stroma in hepatobiliary system. The first case was a
lymphoepithelioma-like undifferentiated carcinoma with focal differentiation of cholangiocarcinoma (cytokeratin
19+) and hepatocellular carcinoma in light microscopy. The infiltration of CD8+ T lymphocytes was observed
in the tumor and the surrounding hepatic parenchyme. In this tumor, EBV was detected and LMP1 was
positive immunohistochemically. The second case showed the mixed features of lymphoepithelioma-like
carcinoma and cholangiocarcinoma with predominant lymphoid stroma. In this case, EBV was detected. LELC
of hepatobiliary system is an entity distinguished from conventional carcinoma with lymphoid stroma, and its
association with EBV warrants further research. (Korean J Hepatol 2007;13:222-227) |
| KeyWords:
Lymphoepithelioma-like carcinoma; Lymphoid stroma; Liver; Bile ducts |
|
|
PDF Links
Full text via DOI
Download Citation
